Increased Transforming Growth Factor-β Production and Gene Expression by Peripheral Blood Monocytes of Hypertensive Patients

Hypertension ◽  
1997 ◽  
Vol 30 (1) ◽  
pp. 134-139 ◽  
Author(s):  
Ettore Porreca ◽  
Concetta Di Febbo ◽  
Gabriella Mincione ◽  
Marcella Reale ◽  
Giovanna Baccante ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Peripheral Blood ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Hypertensive Patients

Hepatocyte growth factor–stimulated invasiveness of monocytes

Blood ◽  
2000 ◽  
Vol 95 (12) ◽  
pp. 3964-3969 ◽  
Author(s):  
Mario Beilmann ◽  
George F. Vande Woude ◽  
Hans-Peter Dienes ◽  
Peter Schirmacher
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Peripheral Blood ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Hepatocyte Growth ◽  
Stimulation Of

Abstract Hepatocyte growth factor (HGF) is a pluripotent cytokine with mitogenic, motogenic, and morphogenic activity for mainly epithelial and endothelial target cells. We previously demonstrated that the specific HGF receptor, MET, is induced in stimulated peripheral blood monocytes. In this study, we analyzed the functional consequences of MET activation in primary cultures of peripheral blood monocytes from healthy donors. After stimulation of MET-expressing monocytes with recombinant HGF, the gene-expression profile of peripheral blood mononuclear cells and monocytes was significantly modulated, especially with regard to genes involved in cell movement. After stimulation of primary cultured monocytes with HGF, invasion assays showed a significantly increased matrigel invasion rate that was completely abolished by neutralizing antibodies to HGF. The HGF-activated invasiveness and the altered gene-expression profile suggest a proinflammatory role for HGF stimulation of monocytes and support the hypothesis that the HGF/MET signaling system plays an important part in the activation of the nonspecific cellular inflammatory response.

Hepatocyte growth factor–stimulated invasiveness of monocytes

Blood ◽  
2000 ◽  
Vol 95 (12) ◽  
pp. 3964-3969 ◽  
Author(s):  
Mario Beilmann ◽  
George F. Vande Woude ◽  
Hans-Peter Dienes ◽  
Peter Schirmacher
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Peripheral Blood ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Hepatocyte Growth ◽  
Stimulation Of

Hepatocyte growth factor (HGF) is a pluripotent cytokine with mitogenic, motogenic, and morphogenic activity for mainly epithelial and endothelial target cells. We previously demonstrated that the specific HGF receptor, MET, is induced in stimulated peripheral blood monocytes. In this study, we analyzed the functional consequences of MET activation in primary cultures of peripheral blood monocytes from healthy donors. After stimulation of MET-expressing monocytes with recombinant HGF, the gene-expression profile of peripheral blood mononuclear cells and monocytes was significantly modulated, especially with regard to genes involved in cell movement. After stimulation of primary cultured monocytes with HGF, invasion assays showed a significantly increased matrigel invasion rate that was completely abolished by neutralizing antibodies to HGF. The HGF-activated invasiveness and the altered gene-expression profile suggest a proinflammatory role for HGF stimulation of monocytes and support the hypothesis that the HGF/MET signaling system plays an important part in the activation of the nonspecific cellular inflammatory response.

scholarly journals Transforming growth factor β-1 enhances Smad transcriptional activity through activation of p8 gene expression

2001 ◽  
Vol 357 (1) ◽  
pp. 249 ◽  
Author(s):  
Andrés C. GARCÍA-MONTERO ◽  
Sophie VASSEUR ◽  
Luciana E. GIONO ◽  
Eduardo CANEPA ◽  
Silvia MORENO ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transcriptional Activity ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

IL-4 down-regulates IL-2-, IL-3-, and GM-CSF-induced cytokine gene expression in peripheral blood monocytes

1994 ◽  
Vol 68 (6) ◽  
pp. 293-298 ◽  
Author(s):  
F. H. M. Cluitmans ◽  
B. H. J. Esendam ◽  
J. E. Landegent ◽  
R. Willemze ◽  
J. H. F. Falkenburg
Keyword(s):  
Gene Expression ◽  
Peripheral Blood ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Gm Csf
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