An E-Box Motif Conveys Inhibitory Activity on the Atrial Natriuretic Peptide Gene

Hypertension ◽  
1996 ◽  
Vol 28 (2) ◽  
pp. 315-319 ◽  
Author(s):  
Miklós Garami ◽  
David G. Gardner
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Inhibitory Activity ◽  
E Box ◽  
Peptide Gene ◽  
Atrial Natriuretic

Alteration of Atrial Natriuretic Peptide and Brain Natriuretic Peptide Gene Expression Associated with Progression and Regression of Cardiac Hypertrophy in Renovascular Hypertensive Rats

1996 ◽  
Vol 90 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Hideo Kawakami ◽  
Hideki Okayama ◽  
Mareomi Hamada ◽  
Kunio Hiwada
Keyword(s):  
Gene Expression ◽  
Atrial Natriuretic Peptide ◽  
Cardiac Hypertrophy ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Mrna Levels ◽  
Hypertensive Rats ◽  
Regression Of Cardiac Hypertrophy ◽  
Peptide Gene ◽  
Atrial Natriuretic

1. We assessed the changes of atrial natriuretic peptide and brain natriuretic peptide gene expression associated with progression and regression of cardiac hypertrophy in renovascular hypertensive rats (RHR). 2. Two-kidney, one-clip hypertensive rats (6-week-old male Wistar) were made and studied 6 (RHR-1) and 10 weeks (RHR-2) after the procedure. Regression of cardiac hypertrophy was induced by nephrectomy at 6 weeks after constriction, and the nephrectomized rats were maintained further for 4 weeks (nephrectomized rat: NEP). Sham operation was performed, and the rats were studied after 6 (Sham-1) and 10 weeks (Sham-2). Atrial natriuretic peptide and brain natriuretic peptide gene expression in the left ventricle was analysed by Northern blotting. 3. Plasma atrial natriuretic peptide and brain natriuretic peptide were significantly higher in RHR-1 and RHR-2 than in Sham-1, Sham-2 and NEP. Atrial natriuretic peptide and brain natriuretic peptide mRNA levels in RHR-1 were approximately 7.2-fold and 1.8-fold higher than those in Sham-1, respectively, and the corresponding levels in RHR-2 were 13.0-fold and 2.4-fold higher than those in Sham-2, respectively. Atrial natriuretic peptide and brain natriuretic peptide mRNA levels of NEP were normalized. Levels of atrial natriuretic peptide and brain natriuretic peptide mRNA were well correlated positively with left ventricular weight/body weight ratios. There was a significant positive correlation between the levels of atrial natriuretic peptide and brain natriuretic peptide mRNA (r = 0.86, P<0.01). 4. We conclude that the expression of atrial natriuretic peptide and brain natriuretic peptide genes is regulated in accordance with the degree of myocardial hypertrophy and that the augmented expression of these two natriuretic peptides may play an important role in the maintenance of cardiovascular haemodynamics in renovascular hypertension.

Atrial Natriuretic Peptide Gene Expression within Invertebrate Hearts

1995 ◽  
Vol 100 (1) ◽  
pp. 61-68 ◽  
Author(s):  
John E. Poulos ◽  
William R. Gower ◽  
Frank E. Friedl ◽  
David L. Vesely
Keyword(s):  
Gene Expression ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Peptide Gene ◽  
Atrial Natriuretic

Expression of the Atrial Natriuretic Peptide Gene in Human Fetal Heart*

1989 ◽  
Vol 69 (4) ◽  
pp. 729-737 ◽  
Author(s):  
D. G. GARDNER ◽  
B. K. HEDGES ◽  
J. WU ◽  
M. C. LAPOINTE ◽  
C. F. DESCHEPPER
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Fetal Heart ◽  
Human Fetal Heart ◽  
Peptide Gene ◽  
Atrial Natriuretic

scholarly journals Atrial Natriuretic Peptide Gene and Plasma Pro-ANP Concentration in Patients with Primary Open-Angle Glaucoma

2008 ◽  
Vol 62 (6) ◽  
pp. 193-198
Author(s):  
Kristīne Baumane ◽  
Liāna Pliss ◽  
Guna Laganovska
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Promoter Region ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Proximal Promoter ◽  
Polymorphism Analysis ◽  
Hypertensive Patients ◽  
Peptide Gene ◽  
Atrial Natriuretic

Atrial Natriuretic Peptide Gene and Plasma Pro-ANP Concentration in Patients with Primary Open-Angle Glaucoma Atrial natriuretic peptide (ANP) appears to have a physiological role in volume and pressure homeostasis. Increased cardiac expression and synthesis of ANP suggest a possible local paracrine function in a number of tissues including the eye. Therefore, the identification of genetic markers may prove to be an important advance in the diagnosis of patients with glaucoma and hypertension. Plasma pro-ANP concentration was measured in 30 clinical patients. A significant elevated level of prehormone was observed in glaucoma patients with blood hypertension. Also, the distribution of the genotypes and alleles of the HpaII, SmaI and ScaI polymorphisms of the ANP gene was examined in 20 hypertensive patients with glaucoma and normotensive controls. The frequencies of the ANP genotypes and alleles did not differ significantly between controls and hypertensive patients. PCR-RFLP (polymerase chain reaction—restriction fragment length polymorphism) analysis shows a T2238→C transition in three hypertensive patients within the stop codon leading to the translation of ANP with an additional arginine. In the current study we also searched for any alterations in the 5' proximal promoter region of the ANP gene (-595 bp - -384 bp) in 20 glaucoma patients with hypertension using PCR-based SSCP (single-strand conformation polymorphism) analysis. No significant alterations in the 5' proximal promoter region of the ANP gene were observed among hypertensive patients. The structure of the ANP hormone encoded gene suggests potential importance in various diseases, but the regulatory function of ANP in the eye requires further investigations.

scholarly journals Association between polymorphisms of the Atrial Natriuretic Peptide gene and proteinuria: a population-based study

Diabetologia ◽  
2003 ◽  
Vol 46 (3) ◽  
pp. 429-432 ◽  
Author(s):  
M. Nannipieri ◽  
R. Posadas ◽  
K. Williams ◽  
E. Politi ◽  
C. Gonzales-Villalpando ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Population Based ◽  
Population Based Study ◽  
Peptide Gene ◽  
Atrial Natriuretic
Sign in / Sign up

Export Citation Format

Share Document