Dispersion of the QT Interval and Autonomic Modulation of Heart Rate in Hypertensive Men With and Without Left Ventricular Hypertrophy

Hypertension ◽  
1996 ◽  
Vol 28 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Juha S. Perkiömäki ◽  
Markku J. Ikäheimo ◽  
Sirkku M. Pikkujämsä ◽  
Asko Rantala ◽  
Mauno Lilja ◽  
...  
Keyword(s):  
Heart Rate ◽  
Left Ventricular Hypertrophy ◽  
Qt Interval ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Autonomic Modulation

Prolongation of the QT interval in heart failure occurs at low but not at high heart rates

2000 ◽  
Vol 98 (5) ◽  
pp. 603-610 ◽  
Author(s):  
P. P. DAVEY ◽  
C. BARLOW ◽  
G. HART
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Left Ventricular Hypertrophy ◽  
Qt Interval ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Qt Interval Prolongation ◽  
Qt Intervals ◽  
Ventricular Structure ◽  
And Function

Abnormal left ventricular structure and function as in, for example, left ventricular hypertrophy or chronic heart failure, is associated with sudden cardiac death and, when the ejection fraction is depressed, with prolongation of the QT interval. The dependence on heart rate of QT interval prolongation in these conditions, and the relationship of any abnormalities either to deranged autonomic nervous system function or to an adverse prognosis, has not been well studied. We therefore investigated (1) the dependence on heart rate of the QT interval, and (2) the relationship between both QT interval and the QT/heart rate slope and markers of adverse prognosis in these two conditions. The QT interval was measured at rest and during exercise in 34 subjects with heart failure, 16 subjects with left ventricular hypertrophy and 16 age-matched controls with normal left ventricular structure and function. QTc (corrected QT) intervals at rest were significantly longer in heart failure patients (471±10 ms) than in controls (421±6 ms) or in subjects with hypertrophy (420±6 ms) (P < 0.05). At peak exercise, despite the attainment of similar heart rates, the QT intervals no longer differed from each other, being 281±7 ms for controls, 296±11 ms in hypertrophy and 303±10 ms in heart failure (no significant difference). The QT/heart rate slope was significantly increased in heart failure [2.3±0.1 ms·(beats/min)-1] compared with controls [1.55±0.06 ms·(beats/min)-1] and hypertrophy [1.66±0.1 ms·(beats/min)-1] (P < 0.001). In left ventricular hypertrophy, despite animal data suggesting that QT interval prolongation should occur, no abnormalities were found in QT intervals at rest or during exercise. The QT/heart rate slope did not relate to any markers for an adverse prognosis, except that of prolongation of QT interval. Long QT intervals were associated principally with impairment of left ventricular systolic function. Our data emphasize the dynamic nature of the QT interval abnormalities found in heart failure.

scholarly journals Electrocardiographic Abnormalities and Mortality in Epilepsy Patients

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 504
Author(s):  
Normunds Suna ◽  
Inga Suna ◽  
Evija Gutmane ◽  
Linda Kande ◽  
Guntis Karelis ◽  
...  
Keyword(s):  
Heart Rate ◽  
General Population ◽  
Left Ventricular Hypertrophy ◽  
Qt Interval ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Mortality Data ◽  
Qtc Interval ◽  
Study Objective

Background and Objectives: People with epilepsy (PWE) have a 2–3 times higher mortality rate than the general population. Sudden unexpected death in epilepsy (SUDEP) comprises a significant proportion of premature deaths, whereas sudden cardiac death (SCD) is among the leading causes of sudden death in the general population. Cardiac pathologies are significantly more prevalent in PWE. Whether electrocardiographic (ECG) parameters are associated with remote death in PWE has yet to be elucidated. The study objective was to assess whether interictal ECG parameters are associated with mortality in the long-term. Materials and Methods: The study involved 471 epilepsy patients who were hospitalized after a bilateral tonic-clonic seizure(s). ECG parameters were obtained on the day of hospitalization (heart rate, PQ interval, QRS complex, QT interval, heart rate corrected QT interval (QTc), ST segment and T wave changes), as well as reported ECG abnormalities. Mortality data were obtained from the Latvian National Cause-of-Death database 3–11, mean 7.0 years after hospitalization. The association between the ECG parameters and the long-term clinical outcome were examined. Results: At the time of assessment, 75.4% of patients were alive and 24.6% were deceased. Short QTc interval (odds ratio (OR) 4.780; 95% confidence interval (CI) 1.668–13.698; p = 0.004) was associated with a remote death. After the exclusion of known comorbidities with high mortality rates, short QTc (OR 4.631) and ECG signs of left ventricular hypertrophy (OR 5.009) were associated with a remote death. Conclusions: The association between routine 12-lead rest ECG parameters—short QTc interval and a pattern of left ventricular hypertrophy—and remote death in epilepsy patients was found. To the best of our knowledge, this is the first study to associate rest ECG parameters with remote death in an epileptic population.

scholarly journals The cardiovascular system in patients with symptomatic and mild primary hyperparathyroidism

2009 ◽  
Vol 55 (3) ◽  
pp. 25-29 ◽  
Author(s):  
I V Voronenko ◽  
N G Mokrysheva ◽  
L Ya Rozhinskaya ◽  
A L Syrkin
Keyword(s):  
Parathyroid Hormone ◽  
Left Ventricular Hypertrophy ◽  
Primary Hyperparathyroidism ◽  
Cardiovascular System ◽  
Qt Interval ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ionized Calcium ◽  
Mild Primary Hyperparathyroidism

The cardiovascular system was analyzed in patients with symptomatic (n = 31) and mild primary hyperparathyroidism (n = 34) whose mean age was 54.6 years; 95% females). In the patients with symptomatic primary hyperparathyroidism, the PQ interval was longer and the QT interval was significantly shorter than those in patients with mild hyperparathyroidism. Left ventricular hypertrophy was noted in 45.2% of patients with symptomatic and in 15.2% of those with mild hyperparathyroidism (p = 0.013). Left ventricular diastolic dysfunction was also more common in the group of symptomatic hyperparathyroidism. There was a statistically significant correlation between the levels of parathyroid hormone, total and ionized calcium and the duration of QT interval and the determinants of diastolic function and left ventricular hypertrophy. The revealed cardiovascular disorders in patients with primary hyperparathyroidism are presumed to depend on the increase rate of parathyroid hormone and total and ionized calcium.

Power spectral analysis of the heart rate in hypertensive patients with and without left ventricular hypertrophy

1998 ◽  
Vol 16 (11) ◽  
pp. 1641-1650 ◽  
Author(s):  
Maria Lorenza Muiesan ◽  
Damiano Rizzoni ◽  
Roberto Zulli ◽  
Maurizio Castellano ◽  
Giorgio Bettoni ◽  
...  
Keyword(s):  
Heart Rate ◽  
Spectral Analysis ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Power Spectral Analysis ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Power Spectral

Effect of heart rate on myocardial blood flow in dogs with left ventricular hypertrophy

1980 ◽  
Vol 239 (5) ◽  
pp. H621-H627
Author(s):  
T. R. Vrobel ◽  
W. S. Ring ◽  
R. W. Anderson ◽  
R. W. Emery ◽  
R. J. Bache
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Left Ventricular Hypertrophy ◽  
Myocardial Blood Flow ◽  
Ventricular Hypertrophy ◽  
Lateral Wall ◽  
Left Ventricular ◽  
Myocardial Mass ◽  
Previous Suggestion ◽  
Heart Rates

Because of the previous suggestion that subendocardial perfusion may be inadequate in the hypertrophied heart, this study was carried out to examine the response of transmural myocardial blood flow to pacing induced tachycardia in dogs with chronic left ventricular hypertrophy. Myocardial hypertrophy, produced by banding the ascending aorta of puppies at 5-6 wk of age, resulted in an 87% average increase in relative left ventricular mass compared with the control dogs. Myocardial blood flow was examined during ventricular pacing at heart rates of 100, 200, and 250 beats/min using radionuclide-labeled microspheres. Mean blood flow per unit myocardial mass was similar in the two groups of dogs at a heart rate of 100 beats/min and increased regularly during pacing in both groups of animals. Increasing heart rates did not change the transmural pattern of myocardial blood flow in the normal dogs, but in the animals with left ventricular hypertrophy pacing at 250 beats/min resulted in a significant redistribution of perfusion away from the subendocardium, with the ratio of subendocardial/subepicardial blood flow falling from 1.03 +/- 0.08 at 100 beats/min to 0.83 +/0 0.06 at 250 beats/min (P < 0.01). This redistribution of blood flow away from the subendocardium was especially marked in the regions encompassing the papillary muscles and the intervening left ventricular lateral wall.

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