Importance of Tyrosine Phosphorylation in Angiotensin II Type 1 Receptor Signaling

Hypertension ◽  
1996 ◽  
Vol 27 (3) ◽  
pp. 476-480 ◽  
Author(s):  
Bernhard Schieffer ◽  
William G. Paxton ◽  
Mario B. Marrero ◽  
Kenneth E. Bernstein
Keyword(s):  
Angiotensin Ii ◽  
Tyrosine Phosphorylation ◽  
Receptor Signaling

scholarly journals Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina

Diabetes ◽  
2008 ◽  
Vol 57 (8) ◽  
pp. 2191-2198 ◽  
Author(s):  
T. Kurihara ◽  
Y. Ozawa ◽  
N. Nagai ◽  
K. Shinoda ◽  
K. Noda ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Neuronal Dysfunction ◽  
Receptor Signaling ◽  
Diabetic Retina

scholarly journals The Bradykinin B2 Receptor Gene Is a Target of Angiotensin II Type 1 Receptor Signaling

2007 ◽  
Vol 18 (4) ◽  
pp. 1140-1149 ◽  
Author(s):  
Bing Shen ◽  
Lisa M. Harrison-Bernard ◽  
Andrew J. Fuller ◽  
Vanessa Vanderpool ◽  
Zubaida Saifudeen ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Gene ◽  
Receptor Signaling ◽  
Bradykinin B2 Receptor

scholarly journals Allosteric Modulation of β-Arrestin-biased Angiotensin II Type 1 Receptor Signaling by Membrane Stretch

2014 ◽  
Vol 289 (41) ◽  
pp. 28271-28283 ◽  
Author(s):  
Wei Tang ◽  
Ryan T. Strachan ◽  
Robert J. Lefkowitz ◽  
Howard A. Rockman
Keyword(s):  
Angiotensin Ii ◽  
Allosteric Modulation ◽  
Receptor Signaling ◽  
Membrane Stretch

Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature

2007 ◽  
Vol 292 (5) ◽  
pp. H2306-H2315 ◽  
Author(s):  
Mami Ishikawa ◽  
Eiichi Sekizuka ◽  
Noriyuki Yamaguchi ◽  
Hiromichi Nakadate ◽  
Satoshi Terao ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Angiotensin Ii ◽  
Oxygen Radical ◽  
Cell Interactions ◽  
Ang Ii ◽  
Receptor Signaling ◽  
Radical Production ◽  
Cerebral Microvasculature ◽  
Oxygen Radical Production

Angiotensin II type 1 (AT1) receptor signaling has been implicated in cerebral microvascular alterations associated with ischemia, diabetes mellitus, hypercholesterolemia, and atherosclerosis. Platelets, which express AT1 receptors, also appear to contribute to the thrombogenic and inflammatory responses that are elicited by these pathological conditions. This study assesses the role of AT1 receptor activation on platelet-leukocyte-endothelial cell interactions elicited in cerebral microvasculature by ischemia and reperfusion. Intravital microscopy was used to monitor the adhesion of platelets and leukocytes that were labeled with different fluorochromes, whereas dihydrorhodamine-123 was used to quantify oxygen radical production in cerebral surface of mice that were either treated with the AT1 receptor agonist Val-angiotensin II (ANG II) or subjected to bilateral common carotid artery occlusion (BCCAO) followed by reperfusion. ANG II elicited a dose- and time- dependent increase in platelet-leukocyte-endothelial cell interactions in cerebral venules that included rolling platelets, adherent platelets on the leukocytes and the endothelial cells, rolling leukocytes, and adherent leukocytes. All of these interactions were attenuated by treatment with either P-selectin or P-selectin glycoprotein ligand 1 (PSGL-1) antibody. The AT1 receptor antagonist candesartan and losartan as well as diphenyleneiodonium, an inhibitor of flavoproteins including NAD(P)H oxidase, significantly reduced the platelet-leukocyte-endothelial cell interactions elicited by either ANG II administration or BCCAO/reperfusion. The increased oxygen radical generation elicited by BCCAO/reperfusion was also attenuated by candesartan. These findings are consistent with an AT1 receptor signaling mechanism, which involves oxygen radical production and ultimately results in P-selectin- and PSGL-1-mediated platelet-leukocyte-endothelial cell interactions in the cerebral microcirculation

Angiotensin II Regulates Vascular and Endothelial Dysfunction: Recent Topics of Angiotensin II Type-1 Receptor Signaling in the Vasculature

2006 ◽  
Vol 4 (1) ◽  
pp. 67-78 ◽  
Author(s):  
Hidekatsu Nakashima ◽  
Hiroyuki Suzuki ◽  
Haruhiko Ohtsu ◽  
James Chao ◽  
Hirotoshi Utsunomiya ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Receptor Signaling

scholarly journals Gestational Exposure to Elevated Testosterone Levels Induces Hypertension via Heightened Vascular Angiotensin II Type 1 Receptor Signaling in Rats1

2014 ◽  
Vol 91 (1) ◽  
Author(s):  
Vijayakumar Chinnathambi ◽  
Amar S. More ◽  
Gary D. Hankins ◽  
Chandra Yallampalli ◽  
Kunju Sathishkumar
Keyword(s):  
Angiotensin Ii ◽  
Receptor Signaling ◽  
Testosterone Levels ◽  
Gestational Exposure

Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy

2010 ◽  
Vol 299 (4) ◽  
pp. F720-F731 ◽  
Author(s):  
Shin-ichiro Masuda ◽  
Kouichi Tamura ◽  
Hiromichi Wakui ◽  
Akinobu Maeda ◽  
Toru Dejima ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Iga Nephropathy ◽  
Renin Angiotensin System ◽  
Human Kidney ◽  
Receptor Signaling ◽  
Angiotensin System ◽  
Biopsy Specimens ◽  
Normal Human Kidney ◽  
Normal Human

The intrarenal renin-angiotensin system plays a crucial role in the regulation of renal circulation and sodium reabsorption through the activation of vascular, glomerular, and tubular angiotensin II type 1 (AT1) receptor signaling. We previously cloned a molecule that specifically interacted with the murine AT1 receptor to inhibit AT1 receptor signaling, which we named ATRAP (for AT1 receptor-associated protein). Since murine ATRAP was shown to be highly expressed in the kidney, in the present study we investigated expression and distribution of human ATRAP in normal kidney and renal biopsy specimens from patients with IgA nephropathy. In the normal human kidney, both ATRAP mRNA and protein were widely and abundantly distributed along the renal tubules from Bowman's capsule to the medullary collecting ducts. In all renal tubular epithelial cells, the ATRAP protein colocalized with the AT1 receptor. In renal biopsy specimens with IgA nephropathy, a significant positive correlation between ATRAP and AT1 receptor gene expression was observed. There was also a positive relationship between tubulointerstitial ATRAP expression and the estimated glomerular filtration rate in patients with IgA nephropathy. Furthermore, we examined the function of the tubular AT1 receptor using an immortalized cell line of mouse distal convoluted tubule cells (mDCT) and found that overexpression of ATRAP by adenoviral gene transfer suppressed the angiotensin II-mediated increases in transforming growth factor-β production in mDCT cells. These findings suggest that ATRAP might play a role in balancing the renal renin-angiotensin system synergistically with the AT1 receptor by counterregulatory effects in IgA nephropathy and propose an antagonistic effect of tubular ATRAP on AT1 receptor signaling.

scholarly journals A Novel Role for Calpain in the Endothelial Dysfunction Induced by Activation of Angiotensin II Type 1 Receptor Signaling

2011 ◽  
Vol 108 (9) ◽  
pp. 1102-1111 ◽  
Author(s):  
Rosario Scalia ◽  
Yulan Gong ◽  
Brett Berzins ◽  
Brin Freund ◽  
Danielle Feather ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Receptor Signaling

scholarly journals Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury

2021 ◽  
Vol 99 (1) ◽  
pp. 148-160 ◽  
Author(s):  
Daniel E. Leisman ◽  
Tiago D. Fernandes ◽  
Vanesa Bijol ◽  
Mabel N. Abraham ◽  
Jake R. Lehman ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Angiotensin Ii ◽  
Kidney Injury ◽  
Receptor Signaling
Sign in / Sign up

Export Citation Format

Share Document