Regional Hemodynamic Effects of the AT 1 Receptor Antagonist CV-11974 in Conscious Renal Hypertensive Rats

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 989-997 ◽  
Author(s):  
Xiao C. Li ◽  
Robert E. Widdop
Keyword(s):  
Receptor Antagonist ◽  
Hemodynamic Effects ◽  
Hypertensive Rats ◽  
Renal Hypertensive Rats

scholarly journals Beneficial hemodynamic effects of bosentan, a mixed ETA and ETB receptor antagonist, in portal hypertensive rats

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 655-659 ◽  
Author(s):  
Philippe Sogni ◽  
Richard Moreau ◽  
Alexandra Gomola ◽  
Adrian Gadano ◽  
Stephane Cailmail ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Hemodynamic Effects ◽  
Hypertensive Rats ◽  
Etb Receptor

Effects of converting-enzyme inhibitor on hemodynamic actions of ANP in renal hypertensive rats

1989 ◽  
Vol 257 (2) ◽  
pp. R365-R369
Author(s):  
M. G. Salom ◽  
F. J. Fenoy ◽  
A. C. Ingles ◽  
L. Martinez ◽  
T. Quesada
Keyword(s):  
Blood Pressure ◽  
Enzyme Inhibitor ◽  
Peripheral Resistance ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Hemodynamic Effects ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Induced Hypotension ◽  
Renal Hypertensive Rats

In the present study, we have evaluated whether the hemodynamic effects of atrial natriuretic peptide (ANP) infusion in two-kidney, one-clip (2K, 1C) hypertensive rats are mediated by inhibition of the renin-angiotensin system (RAS). Hemodynamic determinations were performed by thermodilution in conscious, chronically instrumented animals. ANP (1.5 micrograms.kg-1.min-1) and converting-enzyme (CE) inhibitor captopril (1 mg/kg plus 1 mg.kg-1.h-1), produced a similar fall of blood pressure through different hemodynamic mechanisms. ANP induced hypotension by decreasing cardiac index (CI; from 337.3 +/- 24.9 to 255.1 +/- 21.3 ml.min-1.kg-1, P less than 0.001), whereas a fall in total peripheral resistance (TPR) was observed during CE inhibition (from 0.568 +/- 0.02 to 0.488 +/- 0.02 mmHg.min.ml-1.kg, P less than 0.05). In addition, the ANP-induced decrease in CI was not significantly modified by previous CE inhibition. Furthermore, the decrease in TPR induced by CE inhibition did not change when CE inhibitor was administered during ANP treatment. The results of the present study indicate that the acute hemodynamic responses to ANP in 2K, 1C hypertensive rats are not mediated through antagonism of the vasoconstrictor actions of the RAS.

Hemodynamic effects of chronic infusion of rANP in renal hypertensive rats

1989 ◽  
Vol 256 (5) ◽  
pp. H1393-H1398 ◽  
Author(s):  
F. J. Fenoy ◽  
T. Quesada ◽  
M. Garcia-Salom ◽  
J. C. Romero ◽  
F. J. Salazar
Keyword(s):  
Mean Arterial Pressure ◽  
Cardiac Index ◽  
Arterial Pressure ◽  
Peripheral Resistance ◽  
Plasma Renin ◽  
Hemodynamic Effects ◽  
Hypertensive Rats ◽  
The Third ◽  
Chronic Infusion ◽  
Renal Hypertensive Rats

The purpose of this study was to evaluate the hemodynamic effects induced by an infusion of synthetic rat atrial natriuretic peptide (rANP, 0.5 micrograms/h iv) during 5 consecutive days in conscious normotensive and two-kidney, one-clip hypertensive (2K,1C) rats. Changes in plasma ANP (pANP) levels and plasma renin activity (PRA) were also determined. The administration of ANP in 2K,1C rats induced a significant decrease in mean arterial pressure (MAP) from 169 +/- 3 to 138 +/- 3, and 149 +/- 3 mmHg by 2 and 5 days of infusion, respectively. This hypotension was accompanied by a significant fall in cardiac index (CI) from 400 +/- 16 to 348 +/- 14 ml.min-1.kg-1 after 2 days of ANP treatment. However, CI returned to the basal levels at the third day, and a significant decrease in total peripheral resistance (TPR) was observed by 3 and 5 days of ANP infusion. The administration of the same dose of ANP in normotensive rats did not induce changes in MAP, but CI decreased (P less than 0.001) transitorily during the first 2 days and returned to control values thereafter. Basal pANP levels were significantly elevated in the hypertensive animals (176 +/- 40 pg/ml) when compared with the normotensive rats (82 +/- 10 pg/ml). The ANP infusion resulted in lower (P less than 0.05) pANP levels in hypertensive (1,017 +/- 234 pg/ml) than in normotensive rats (3,466 +/- 975 pg/ml). PRA did not change in any group during the administration of ANP.(ABSTRACT TRUNCATED AT 250 WORDS)

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