scholarly journals In vivo effect of calcitriol on calcium transport and calcium binding proteins in the spontaneously hypertensive rat.

Hypertension ◽  
1994 ◽  
Vol 24 (2) ◽  
pp. 176-182 ◽  
Author(s):  
C M Roullet ◽  
J B Roullet ◽  
A S Martin ◽  
D A McCarron
Keyword(s):  
Calcium Binding ◽  
Calcium Transport ◽  
Binding Proteins ◽  
Spontaneously Hypertensive Rat ◽  
Calcium Binding Proteins ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Intestinal calcium transport in the spontaneously hypertensive rat: response to calcium depletion

1986 ◽  
Vol 250 (4) ◽  
pp. G412-G419
Author(s):  
H. P. Schedl ◽  
D. L. Miller ◽  
R. L. Horst ◽  
H. D. Wilson ◽  
K. Natarajan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Small Intestine ◽  
Calcium Transport ◽  
Spontaneously Hypertensive Rat ◽  
Calcium Depletion ◽  
Spontaneously Hypertensive ◽  
Distal Small Intestine ◽  
Wistar Kyoto

We previously found intestinal Ca2+ transport to be lower in the spontaneously hypertensive (SH) as compared with the Wistar-Kyoto control (WKY) rat. These animals were fed a relatively high (1%) Ca2+ diet, and the concentration of 1 alpha,25-dihydroxycholecalciferol [1 alpha,25(OH)2D3] in serum was the same in both groups. In the present experiment we tested the possibility that the lower Ca2+ transport in the SH rat was the result of unresponsiveness to 1 alpha,25(OH)2D3. We fed diets high and low in Ca2+ and measured serum 1 alpha,25(OH)2D3 and Ca2+ transport. Serum 1 alpha,25(OH)2D3 increased in response to Ca2+ depletion at both 5 and 12 wk in both the WKY and SH rat. With high-Ca2+ diet, Ca2+ transport was lower in SH than in WKY when studied 1) in vitro in duodenum at 5 wk of age, and 2) in vivo in proximal and distal small intestine at 12 wk of age. Ca2+ transport increased in SH in response to Ca2+ depletion, but not in WKY, except in distal small intestine in vivo at 12 wk. In summary, although Ca2+ transport is lower in the SH as compared with the WKY rat when vitamin D activity is basal through feeding a high-Ca2+ diet, Ca2+ transport increases in the SH rat in response to the increase in 1 alpha,25(OH)2D3 produced by feeding a low-Ca2+ diet. We conclude that 1) the vitamin D-regulated component of mediated Ca2+ transport is intact in the SH rat and is unrelated to hypertension, and 2) mediated Ca2+ transport under basal conditions, i.e., nonvitamin D-regulated, differs in the SH and WKY rats and may be related to hypertension.

scholarly journals In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart

2012 ◽  
Vol 95 (1) ◽  
pp. 69-76 ◽  
Author(s):  
M. S. Dodd ◽  
D. R. Ball ◽  
M. A. Schroeder ◽  
L. M. Le Page ◽  
H. J. Atherton ◽  
...  
Keyword(s):  
Rat Heart ◽  
Spontaneously Hypertensive Rat ◽  
Cardiac Metabolism ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
And Function
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