scholarly journals Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats.

Hypertension ◽  
1993 ◽  
Vol 21 (3) ◽  
pp. 294-300 ◽  
Author(s):  
R Larivière ◽  
G Thibault ◽  
E L Schiffrin
Keyword(s):  
Blood Vessels ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Spontaneously Hypertensive ◽  
Endothelin 1 ◽  
Acetate Salt

Lack of increase in platelet Ca2+ and Na+ in deoxycorticosterone acetate-salt hypertensive rats

1994 ◽  
Vol 267 (5) ◽  
pp. R1288-R1293 ◽  
Author(s):  
M. Ishida ◽  
T. Ishida ◽  
H. Matsuura ◽  
R. Ozono ◽  
G. Kajiyama ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Peak Response ◽  
Spontaneously Hypertensive ◽  
Acetate Salt ◽  
Rate Of Recovery ◽  
And Control

We have previously characterized abnormal Ca2+ handling in platelets of spontaneously hypertensive rats (SHRs). In this study, we investigated whether cellular Ca2+ metabolism and/or Na+ concentration is altered in platelets of deoxycorticosterone acetate-salt hypertensive rats (DOCA rats). The resting cytosolic Ca2+ concentration ([Ca2+]i) in platelets was significantly lower in DOCA rats than controls (54.5 +/- 1.4 vs. 61.2 +/- 2.3 nmol/l). The amplitude of the [Ca2+]i transient induced by thrombin was significantly increased in the absence, but not the presence, of external Ca2+ in DOCA rats compared with control rats. The [Ca2+]i response to 5 mumol/l ionomycin in the Ca(2+)-free buffer was greater in DOCA rats than in controls (546 +/- 23 vs. 470 +/- 18 nmol/l), indicating larger intracellular Ca2+ stores. The rate of recovery of [Ca2+]i after the peak response to thrombin was decreased in DOCA rats (79% at 0.1 U/ml and 91% at 1.0 U/ml thrombin of control rats). Cytosolic Na+ concentration ([Na+]i) in platelets was similar in DOCA and control rats. Altered Ca2+ levels are not correlated with [Na+]i in this salt-sensitive hypertensive model. Therefore, an increased [Ca2+]i is not an obligatory phenomenon in hypertension.

Expression of endothelin-1 gene in blood vessels of adult spontaneously hypertensive rats

Life Sciences ◽  
1995 ◽  
Vol 56 (22) ◽  
pp. 1889-1896 ◽  
Author(s):  
Richard Larivière ◽  
Pavol Sventek ◽  
Ernesto L. Schiffrin
Keyword(s):  
Blood Vessels ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Endothelin 1
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