scholarly journals Sympathetic nerve activity and blood pressure in normotensive backcross rats genetically related to the spontaneously hypertensive rat.

Hypertension ◽  
1979 ◽  
Vol 1 (6) ◽  
pp. 598-604 ◽  
Author(s):  
W V Judy ◽  
A M Watanabe ◽  
W R Murphy ◽  
B S Aprison ◽  
P L Yu
Keyword(s):  
Blood Pressure ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Spontaneously Hypertensive Rat ◽  
Nerve Activity ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

scholarly journals Alteration of Sympathetic Nerve Activity (SNA) with High Sodium Diet and Foot-Shock in Spontaneously Hypertensive Rat (SHR)

1988 ◽  
Vol 29 (4) ◽  
pp. 562-562
Author(s):  
Hiroaki Tomori ◽  
Hiroshi Kawamura ◽  
Masahiro Maki ◽  
Hideaki Higashi ◽  
Kazuyoshi Tsukamoto ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Spontaneously Hypertensive Rat ◽  
Nerve Activity ◽  
Spontaneously Hypertensive ◽  
High Sodium ◽  
Sodium Diet ◽  
Hypertensive Rat ◽  
High Sodium Diet

scholarly journals Sympathetic Nerve Activity and Baroreflex are Strongly Altered in a Context of Severe Hypertension Using the Spontaneously Hypertensive Rat Model Associated with Chronic Reduction of Nitric Oxide

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Christine Vayssettes-Courchay ◽  
Jonathan Melka ◽  
Clothilde Philouze ◽  
Najah Harouki
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Spontaneously Hypertensive Rat ◽  
Severe Hypertension ◽  
Temporal Correlation ◽  
Hypertensive Rats ◽  
Nerve Activity ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Wistar Kyoto

The aim of our study is to investigate the sympathetic output and baroreflex via renal sympathetic nerve activity (RSNA) recording in a model of severe hypertension which exhibits arterial, cardiac, and renal damages, the spontaneously hypertensive rat (SHR) under lowered NO bioavailability. SHR are treated from 18 to 20 weeks of age with a low dose of L-NAME, a NO synthase inhibitor, in drinking water (SHRLN) and compared to SHR and normotensive Wistar Kyoto (WKY) rats. After the two-week treatment, rats are anesthetized for RSNA, mean blood pressure (MBP), and heart rate (HR) recording. MBP is higher in SHR than in WKY and higher in SHRLN than in SHR. Compared to WKY, SHR displays an alteration in the baroreflex with a displacement of the sympathoinhibition curve to highest pressures; this displacement is greater in SHRLN rats. The bradycardic response is reduced in SHRLN compared to both SHR and WKY. In hypertensive rats, SHR and SHRLN, basal RSNA is modified, the maximal amplitude of burst is reduced, but minimal values are increased, indicating an increased basal RSNA with reduced bursting activity. The temporal correlation between RSNA and HR is preserved in SHR but altered in 10 SHRLN out of 10. The RSNA inhibition triggered by the Bezold–Jarisch reflex activation is not modified in hypertensive rats, SHR or SHRLN, in contrast to that triggered by the baroreflex. Histological analysis of the carotid bifurcation does not reveal any abnormality in SHRLN at the level of the carotid sinus. In conclusion, data indicate that the sympathetic outflow is altered in SHRLN with a strong reduction of the baroreflex sympathoinhibition and suggest that its central pathway is not involved. These additional results on SHRLN also confirm the usefulness of this model of severe hypertension with multiple target organ damages.

Sympathetic nerve activity: role in regulation of blood pressure in the spontaenously hypertensive rat.

1976 ◽  
Vol 38 (6) ◽  
pp. 21-29 ◽  
Author(s):  
W V Judy ◽  
A M Watanabe ◽  
D P Henry ◽  
H R Besch ◽  
W R Murphy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Hypertensive Rat ◽  
Regulation Of Blood Pressure

scholarly journals Exacerbated pressor and sympathoexcitatory effects of central Elabela in spontaneously hypertensive rats

2020 ◽  
Vol 318 (1) ◽  
pp. H124-H134 ◽  
Author(s):  
Zhi Geng ◽  
Chao Ye ◽  
Ying Tong ◽  
Feng Zhang ◽  
Ye-Bo Zhou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sympathetic Nerve ◽  
Spontaneously Hypertensive Rats ◽  
Sympathetic Nerve Activity ◽  
Akt Pathway ◽  
Sympathetic Activation ◽  
Hypertensive Rats ◽  
Nerve Activity ◽  
Vasopressin Release ◽  
Spontaneously Hypertensive

Elabela (ELA) is a newly discovered peptide that acts as a novel endogenous ligand of angiotensin receptor-like 1 (APJ) receptor. This study was designed to evaluate the effects of ELA-21 in paraventricular nucleus (PVN) on blood pressure and sympathetic nerve activity in spontaneously hypertensive rats (SHR). Experiments were performed in male Wistar-Kyoto rats (WKY) and SHR. ELA expression was upregulated in PVN of SHR. PVN microinjection of ELA-21 increased renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP), heart rate (HR), plasma norepinephrine, and arginine vasopressin (AVP) levels in SHR. Intravenous injection of ELA-21 significantly decreased MAP and HR in both WKY and SHR, but only induced a slight decrease in RSNA. APJ antagonist F13A in PVN abolished the effects of ELA-21 on RSNA, MAP and HR. Intravenous infusion of both ganglionic blocker hexamethonium and AVP V1a receptor antagonist SR49059 caused significant reduction in the effects of ELA-21 on RSNA, MAP and HR in SHR, while combined administration of hexamethonium and SR49059 abolished the effects of ELA-21. ELA-21 microinjection stimulated Akt and p85α subunit of phosphatidylinositol 3-kinase (PI3K) phosphorylation in PVN, whereas PI3K inhibitor LY294002 or Akt inhibitor MK-2206 almost abolished the effects of ELA-21 on RSNA, MAP, and HR. Chronic PVN infusion of ELA-21 induced sympathetic activation, hypertension, and AVP release accompanied with cardiovascular remodeling in normotensive WKY. In conclusion, ELA-21 in PVN induces exacerbated pressor and sympathoexcitatory effects in hypertensive rats via PI3K-Akt pathway. NEW & NOTEWORTHY We demonstrated that PVN microinjection of ELA-21 increases sympathetic nerve activity and blood pressure, which can be abolished by pretreatment of APJ antagonist. This is the first demonstration that central ELA can induce hypertension. The pressor effects in PVN are mediated by both sympathetic activation and vasopressin release via PI3K-Akt pathway. Our data confirm that ELA is upregulated in the PVN of SHR and so may be involved in the pressor and sympathoexcitatory effects in hypertension.

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