Supercritical CO2 Viral-Inactivated Allogenic Bone Graft in Maxillary Sinus Augmentation Procedures: 10-Year Retrospective Clinical and Radiographic Results

2021 ◽  
Vol 41 (3) ◽  
pp. 433-441
Author(s):  
Jean-Jacques Chalard
Keyword(s):  
Bone Graft ◽  
Maxillary Sinus ◽  
Supercritical Co2 ◽  
Sinus Augmentation ◽  
Allogenic Bone ◽  
Maxillary Sinus Augmentation ◽  
Allogenic Bone Graft

scholarly journals Biphasic Calcium Phosphate Biomaterials: Stem Cell-Derived Osteoinduction or In Vivo Osteoconduction? Novel Insights in Maxillary Sinus Augmentation by Advanced Imaging

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2159
Author(s):  
Giovanna Iezzi ◽  
Antonio Scarano ◽  
Luca Valbonetti ◽  
Serena Mazzoni ◽  
Michele Furlani ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Maxillary Sinus ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphates ◽  
Three Dimensional ◽  
Sinus Augmentation ◽  
Native Bone ◽  
Maxillary Sinus Augmentation ◽  
Posterior Maxilla

Maxillary sinus augmentation is often necessary prior to implantology procedure, in particular in cases of atrophic posterior maxilla. In this context, bone substitute biomaterials made of biphasic calcium phosphates, produced by three-dimensional additive manufacturing were shown to be highly biocompatible with an efficient osteoconductivity, especially when combined with cell-based tissue engineering. Thus, in the present research, osteoinduction and osteoconduction properties of biphasic calcium-phosphate constructs made by direct rapid prototyping and engineered with ovine-derived amniotic epithelial cells or amniotic fluid cells were evaluated. More in details, this preclinical study was performed using adult sheep targeted to receive scaffold alone (CTR), oAFSMC, or oAEC engineered constructs. The grafted sinuses were explanted at 90 days and a cross-linked experimental approach based on Synchrotron Radiation microCT and histology analysis was performed on the complete set of samples. The study, performed taking into account the distance from native surrounding bone, demonstrated that no significant differences occurred in bone regeneration between oAEC-, oAFMSC-cultured, and Ctr samples and that there was a predominant action of the osteoconduction versus the stem cells osteo-induction. Indeed, it was proven that the newly formed bone amount and distribution decreased from the side of contact scaffold/native bone toward the bulk of the scaffold itself, with almost constant values of morphometric descriptors in volumes more than 1 mm from the border.

PTH1-34 improves devitalized allogenic bone graft healing in a murine femoral critical size defect

Injury ◽  
2021 ◽  
Author(s):  
Tito Rocha ◽  
Amanda S. Cavalcanti ◽  
Ana Carolina Leal ◽  
Rhayra B. Dias ◽  
Rafaela Sartore da Costa ◽  
...  
Keyword(s):  
Bone Graft ◽  
Critical Size ◽  
Critical Size Defect ◽  
Allogenic Bone ◽  
Graft Healing ◽  
Allogenic Bone Graft
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