Evaluation of Recombinant Human Platelet-Derived Growth Factor or Enamel Matrix Derivative Plus Calcium Hydroxide for Pulp Capping: A Randomized Controlled Human Clinical Trial

2020 ◽  
Vol 40 (5) ◽  
pp. 645-654
Author(s):  
Khalid Al-Hezaimi ◽  
Jafar Naghshbandi ◽  
Raed Alhuzaimi ◽  
Faisal Alonaizan ◽  
Ibrahim AlQwizany ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Growth Factor ◽  
Human Platelet ◽  
Platelet Derived Growth Factor ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Human Clinical Trial ◽  
Pulp Capping ◽  
Randomized Controlled ◽  
Matrix Derivative

scholarly journals Human Periodontal Fibroblast Response to Enamel Matrix Derivative, Amelogenin, and Platelet-Derived Growth Factor-BB

2006 ◽  
Vol 77 (7) ◽  
pp. 1242-1252 ◽  
Author(s):  
Chol H. Chong ◽  
David L. Carnes ◽  
Alan J. Moritz ◽  
Thomas Oates ◽  
Ok Hee Ryu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Platelet Derived Growth Factor ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Matrix Derivative

scholarly journals Healing of intrabony defects following regenerative surgery by means of single-flap approach in conjunction with either hyaluronic acid or an enamel matrix derivative: a 24-month randomized controlled clinical trial

2021 ◽  
Author(s):  
Andrea Pilloni ◽  
Mariana A. Rojas ◽  
Lorenzo Marini ◽  
Paola Russo ◽  
Yoshinori Shirakata ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Test Group ◽  
Enamel Matrix Derivative ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Enamel Matrix ◽  
Randomized Controlled Clinical Trial ◽  
Intrabony Defects ◽  
Randomized Controlled ◽  
Matrix Derivative

Abstract Objectives The aim of this randomized controlled clinical trial was to compare the clinical outcomes obtained in intrabony defects following regenerative periodontal surgery using the single-flap approach (SFA) in conjunction with either hyaluronic acid (HA) or enamel matrix derivative (EMD). Materials and methods Thirty-two intrabony defects in 32 healthy subjects were randomly assigned: HA (test group) or EMD (control group). Clinical attachment level (CAL), probing depth (PD), gingival recession (REC), and bleeding on probing (BOP) were recorded at baseline,12, 18, and 24 months after surgery. Results At 24 months, both treatments resulted in statistically significant clinical improvements evidenced by PD-reduction and CAL-gain (p<0.001). The mean CAL-gain was 2.19±1.11 mm in the test and 2.94±1.12 mm in the control sites (p=0.067). PD-reduction was statistically significantly higher for the control group (4.5±0.97 mm) than the test group (3.31±0.70 mm), (p=0.001). CAL-gain ≤ 3 mm was observed in 87.5% and in 62.5% of the test and control sites, respectively. Test sites showed slightly lower REC values than the control sites. No statistically significant differences were found for BOP between treatments. Conclusions The present findings indicate that both treatments led to statistically significant clinical improvements compared to baseline, although the application of EMD resulted in statistically significantly higher PD-reduction compared to the use of HA. Clinical relevance The use of HA in conjunction with a SFA resulted in significant PD-reduction and CAL-gain, pointing to the potential clinical relevance of this material in regenerative periodontal surgery.

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