Effects of Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting: A Comparative Randomized Controlled Clinical Trial

2017 ◽  
Vol 37 (5) ◽  
pp. e270-e278 ◽  
Author(s):  
Mustafa Ozcan ◽  
Onur Ucak ◽  
Bahar Alkaya ◽  
Seray Keceli ◽  
Gulsah Seydaoglu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Platelet Rich Fibrin ◽  
Free Gingival Graft ◽  
Randomized Controlled ◽  
Gingival Graft

scholarly journals Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Siamak Yaghobee ◽  
Nina Rouzmeh ◽  
Mina Taheri ◽  
Hoori Aslroosta ◽  
Sanaz Mahmoodi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Recipient Site ◽  
Time Points ◽  
Free Gingival Graft ◽  
Randomized Controlled ◽  
And Control ◽  
Gingival Graft

Abstract Background Free gingival graft (FGG) is a highly predictable method to increase the width of keratinized gingiva. Various materials have been reported to accelerate the wound healing process. Considering the positive effect of EPO on dermal wound healing this study aimed to investigate the effects of EPO on the rate of healing and degree of inflammation in free gingival grafts. Methods Seventeen patients with bilateral lack of keratinized gingiva in mandible were selected for this clinical trial. The surgical intervention was performed after phase I periodontal therapy. Recipient site was prepared apical to the mucogingival line, and FGG was harvested from the palate. Before graft placement, the test side and control side were treated with 1 ml of EPO 4000 IU/ml and distilled water, respectively, for 2 min. On days 7, 14, 21, 28, 60, and 90 after surgery, the grafted sites were examined by blinded observers to compare the healing and inflammation of the areas. Results All the 17 patients completed the surgeries and follow-up examinations. Direct examination revealed significantly better healing in EPO group only on the 28th day. Assessment of the photographs showed a significant value in favor of the test group at some other time points as well. The EPO group demonstrated less inflammation, which was statistically significant in many time points. The graft area was 80.88 ± 30.21 mm2 and 71.35 ± 15.62 mm2 in the EPO and control groups, respectively. The difference was not significant, though. Conclusions Topical application of erythropoietin can accelerate the healing of gingival grafts and reduce the inflammation during healing period. The final graft outcome, nevertheless, does not seem to be influenced by EPO. Trial registration This was a split-mouth randomized controlled clinical trial (IRCT201201278830N1). The first registration date: 2016-10-22

scholarly journals Use of Mucograft Collagen Matrix® versus Free Gingival Graft to Augment Keratinized Tissue Around Teeth: A Randomized Controlled Clinical Trial

2020 ◽  
Author(s):  
Amirreza Rokn ◽  
Hadi Zare ◽  
Pardis Haddadi
Keyword(s):  
Clinical Trial ◽  
Dimensional Change ◽  
Collagen Matrix ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Double Blind ◽  
Free Gingival Graft ◽  
Randomized Controlled ◽  
Keratinized Tissue ◽  
Gingival Graft

Objectives: This study aimed to evaluate the mucograft collagen matrix (CM) to increase keratinized tissue around teeth compared to free gingival graft (FGG). Materials and Methods: The present double-blind, randomized, controlled clinical trial studied 12 patients who had 2 mm or less keratinized gingiva bilaterally around mandibular premolars. The 6-month width of keratinized tissue, periodontal parameters (preoperatively and 1, 3, and 6 months postoperatively), color match, pain, and total surgical time were measured. Results: The mean dimensional change of keratinized gingiva 6 months postoperatively was 4.1±0.7 mm for FGG and 8±1.7 mm for CM. Periodontal parameters were not affected in the two groups. The CM group had a significantly lower pain, experienced less surgery time, and gained better aesthetics compared to the FGG group. Conclusion: CM appears to be a suitable substitute for FGG in procedures designed to increase keratinized tissue around teeth. It has remarkable benefits, such as acceptable keratinized tissue gain, less pain, less surgical chair time, and better aesthetics.

Platelet-rich fibrin as an alternative adjunct to tendon-exposed wound healing: A randomized controlled clinical trial

Burns ◽  
2019 ◽  
Vol 45 (5) ◽  
pp. 1152-1157 ◽  
Author(s):  
Shuang Zhang ◽  
DongSheng Cao ◽  
Juan Xie ◽  
HongHong Li ◽  
ZengHong Chen ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Platelet Rich Fibrin ◽  
Randomized Controlled
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