scholarly journals Isobolographic Analysis in Mice of the Interaction of Gabapentin and Nortriptyline in Relieving Orofacial Pain

2013 ◽  
Vol 27 (4) ◽  
pp. 361-366 ◽  
Author(s):  
Hugo F. Miranda ◽  
Viviana Noriega ◽  
Pilar Zanetta ◽  
Juan Carlos Prieto
Keyword(s):  
Orofacial Pain ◽  
Isobolographic Analysis

Synergistic Antinociceptive Effects of Ketamine and Morphine in the Orofacial Capsaicin Test in the Rat

2003 ◽  
Vol 99 (4) ◽  
pp. 969-975 ◽  
Author(s):  
Pedro Alvarez ◽  
Gloria Saavedra ◽  
Alejandro Hernández ◽  
Carlos Paeile ◽  
Teresa Pelissier
Keyword(s):  
Animal Behavior ◽  
Orofacial Pain ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Nociceptive Behavior ◽  
Isobolographic Analysis ◽  
Aspartate Receptor ◽  
Sprague Dawley Rats ◽  
Antinociceptive Effects ◽  
Dose Dependent

Background The clinical efficacy of the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine for treating orofacial pain has already been reported. Side effects related to psychotomimetic disturbances, however, limit ketamine use as an analgesic. Theoretically, this limitation could be minimized by using low doses of ketamine in combination with other analgesics. In the present study, the potential synergistic antinociceptive interaction between ketamine and morphine in the orofacial capsaicin test in rats was investigated. Methods Male Sprague-Dawley rats were subcutaneously injected with solvent, ketamine, morphine, or combination of both drugs. Thirty minutes later, the orofacial capsaicin test was performed by injecting of 1.5 microg/25 microl of a capsaicin solution into the vibrissa pad. Animal behavior was recorded on videotape and analyzed off-line. The total time spent on rubbing-scratching nociceptive behavior during a period of 42 min was measured. Results Subcutaneously administered ketamine (0.4, 1.25, 4, 12.5 mg/kg), morphine (0.5, 1, 2, 4 mg/kg) and ketamine + morphine (0.20 + 0.12, 0.40 + 0.24, 0.80 + 0.49, 1.61 + 0.97, 3.21 + 1.94 mg/kg) reduced the rat facial rubbing-scratching behavior in a dose-dependent manner. Isobolographic analysis showed that the ketamine + morphine association inhibited the studied behavior in a superadditive manner. Conclusions These results indicate that ketamine and morphine have antinociceptive effects on the orofacial capsaicin test. Furthermore, their combination produces synergistic antinociception. It is therefore suggested that, used together, ketamine and morphine might be clinically efficient at lower doses than those currently used when administered separately. This could provide a useful strategy for the clinical management of orofacial pain.

scholarly journals Isobolographic Antinociception of Nonsteroidal Anti-inflammatory Drugs in Rodent Formalin Orofacial Pain

2020 ◽  
Author(s):  
Viviana Noriega ◽  
Fernando Sierralta ◽  
Nicolás Aranda ◽  
Ramón Sotomayor-Zárate ◽  
Paula Poblete ◽  
...  
Keyword(s):  
Response Curve ◽  
Orofacial Pain ◽  
Mechanisms Of Action ◽  
Maximum Effect ◽  
Male Mice ◽  
Post Herpetic Neuralgia ◽  
Isobolographic Analysis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Dose Dependent

Background: Diverse studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception through the inhibition of cyclooxygenases. Objectives: This study evaluated the effect of NSAIDs in inducing antinociception either alone or in combination in mice formalin orofacial pain. Methods: Male mice were injected intraperitoneally with dexibuprofen, dexketoprofen, diclofenac meloxicam, metamizole and piroxicam. Then from a dose-response curve the ED50 (dose that produce 50% of maximum effect) was obtained from each drug. Results: The administration of NSAIDs produced a dose-dependent antinociception in both phases of the assay with different potency. Then, combinations of the cited NSAIDs were tested and analyzed by isobolographic analysis. The results demonstrate that the nocifensive response induced when dexketoprofen (DEX), the dextrorotatory enantiomer of the S (+) configuration of ketoprofen, was combined with piroxicam, diclofenac, dexibuprofen, metamizole, and meloxicam, was synergistic, either in Phase I or Phase II of the formalin orofacial mice assay. Conclusion: The data demonstrated that the NSAIDs administered alone or in combination produce antinociception. These effects need to be explained by other mechanisms of action of NSAIDs other than the simple inhibition of COXs. The findings may be relevant for the relief of acute or chronic pain such as migraine, post‐herpetic neuralgia and tooth pain.

Pain management of Dental Caries (Krimi Danta) - A Case Report

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Amit Kumar ◽  
Mahamad Yunus S. Nabooji
Keyword(s):  
Dental Caries ◽  
Orofacial Pain ◽  
Common Type ◽  
Tooth Decay ◽  
Cotton Swab ◽  
Argemone Mexicana ◽  
Liver Disorders ◽  
Tooth Structure ◽  
Tingling Sensation ◽  
Dental Emergency

Dental caries/Tooth decay is progressive destruction of tooth structure, leading to tooth ache. Tooth ache is the most common type of orofacial pain and when severe it is considered a dental emergency. Pain killers will be the first option to get rid of pain but use of these pain killers have many adverse effects and also its over prescription leads to kidney disorders, liver disorders etc. and in Ayurveda for the management of pain in Krimidanta it is mentioned that, Krimighna (anti-microbial), Vatagna (which relieves Vata) and Ushnaveerya Dravyas (drugs with hot potency) are to be used which can relieve the toothache and discolouration. Hence here an attempt was made to find out an alternate medicine which is effective, has no contraindications and with no side effects. Here the patient was treated with Dantapichu (soaked cotton swab) with Katuparni Ksheera (milk of Argemone Mexicana Linn.) as a local application. After the treatment, a significant response in various symptoms such as tooth pain, tingling sensation and swelling was observed.

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