Albumin-Impregnated Allograft Filling of Surgical Extraction Sockets Achieves Better Bone Remodeling Than Filling with Either Blood Clot or Bovine Xenograft

Laszlo Simonffy; Fanni Minya; Balint Trimmel; Zsombor Lacza; Csaba Dobo-Nagy

doi:10.11607/jomi.7554

Albumin-Impregnated Allograft Filling of Surgical Extraction Sockets Achieves Better Bone Remodeling Than Filling with Either Blood Clot or Bovine Xenograft

The International Journal of Oral & Maxillofacial Implants ◽

10.11607/jomi.7554 ◽

2020 ◽

Vol 35 (2) ◽

pp. 297-304

Author(s):

Laszlo Simonffy ◽

Fanni Minya ◽

Balint Trimmel ◽

Zsombor Lacza ◽

Csaba Dobo-Nagy

Keyword(s):

Bone Remodeling ◽

Blood Clot ◽

Surgical Extraction ◽

Bovine Xenograft

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Natural Bovine Anorganic Apatite and Collagen Presents Osteoconductivity and Contribute to Bone Repair of Rat Calvaria Critical Size Defect

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.396-398.249 ◽

2008 ◽

Vol 396-398 ◽

pp. 249-252 ◽

Cited By ~ 2

Author(s):

I.I.C. Silva ◽

S. Pimentel-Soares ◽

Rafael C. Bittencourt ◽

José Mauro Granjeiro

Keyword(s):

Bone Repair ◽

Critical Size ◽

Blood Clot ◽

Autogenous Bone ◽

Histopathological Analysis ◽

Critical Size Defect ◽

Critical Size Defects ◽

Rat Calvaria ◽

Bovine Xenograft

The aim of this study was verify the biological efficacy of the use of a xenograft for bone loss therapy. Blood clot, particulate autogenous bone or anorganic bovine xenograft filled critical size defects (CSD) in rat calvaria (8mm diameter). After 0, 7, 30 and 90 days the animals were killed and macroscopic, radiographic and histopathological analysis were conducted. Although no treatment promoted the total closure of bone defect, autogenous bone group had better bone repair after 90 days, followed by xenograft group that exhibited direct bone neoformation onto, and around, the particles confirming its osteoconductivity. In conclusion, the xenograft tested in vivo showed biocompatibility, biodegradability and osteoconductive properties in rat calvaria CSD.

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Does short-term administration of glucagon-like peptide type 2 affect bone mass and markers of bone remodeling in short bowel patients?

Gastroenterology ◽

10.1016/s0016-5085(01)81558-4 ◽

2001 ◽

Vol 120 (5) ◽

pp. A314-A314

Author(s):

K HADERSLEV ◽

P JEPPESEN ◽

B HARTMANN ◽

J THULESEN ◽

J GRAFF ◽

...

Keyword(s):

Bone Mass ◽

Bone Remodeling ◽

Short Term ◽

Short Bowel ◽

Term Administration ◽

Glucagon Like Peptide

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FDA: OCs With Drospirenone May Raise Blood Clot Risk

Family Practice News ◽

10.1016/s0300-7073(12)70372-9 ◽

2012 ◽

Vol 42 (8) ◽

pp. 29

Author(s):

ELIZABETH MECHCATIE

Keyword(s):

Blood Clot

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A Monoclonal Antibody-Based Enzyme Immunoassay for Fibrin Degradation Products in Plasma

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642777 ◽

1988 ◽

Vol 59 (02) ◽

pp. 310-315 ◽

Cited By ~ 64

Author(s):

P W Koppert ◽

E Hoegee-de Nobel ◽

W Nieuwenhuizen

Keyword(s):

Enzyme Immunoassay ◽

Degradation Products ◽

Blood Clot ◽

Tissue Type ◽

Fibrin Degradation Products ◽

Type Plasminogen Activator ◽

Strong Positive Reaction ◽

Sandwich Type ◽

Capture Antibody

SummaryWe have developed a sandwich-type enzyme immunoassay (EIA) for the quantitation of fibrin degradation products (FbDP) in plasma with a time-to-result of only 45 minutes.* The assay is based on the combination of the specificities of two monoclonal antibodies (FDP-14 and DD-13), developed in our institute. FDP-14, the capture antibody, binds both fibrinogen degradation products (FbgDP) and FbDP, but does not react with the parent fibrin(ogen) molecules. It has its epitope in the E-domain of the fibrinogen molecule on the Bβ-chain between amino acids 54-118. Antibody DD-13 was raised using D-dimer as antigen and is used as a tagging antibody, conjugated with horse-radish peroxidase. A strong positive reaction is obtained with a whole blood clot lysate (lysis induced by tissue-type plasminogen activator) which is used as a standard. The EIA does virtually not detect FbgDP i. e. purified fragments X, Y, or FbgDP generated in vitro in plasma by streptokinase treatment. This indicates that the assay is specific for fibrin degradation products.We have successfully applied this assay to the plasma of patients with a variety of diseased states. In combination with the assay previously developed by us for FbgDP and for the total amount of FbgDP + FbDP (TDP) in plasma, we are now able to study the composition of TDP in patients plasma in terms of FbgDP and FbDP.

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Dependence of Blood Clot Lysis on the Mode of Transport of Urokinase into the Clot - A Magnetic Resonance Imaging Study in Vitro

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648188 ◽

1991 ◽

Vol 65 (05) ◽

pp. 549-552 ◽

Cited By ~ 55

Author(s):

A Blinc ◽

G Planinšič ◽

D Keber ◽

O Jarh ◽

G Lahajnar ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Pressure Difference ◽

Volume Flow Rate ◽

Blood Clot ◽

Linear Regression Analysis ◽

Imaging Study ◽

Clot Lysis ◽

Resonance Imaging

SummaryMagnetic resonance imaging was employed to study the dependence of clot lysing patterns on two different modes of transport of urokinase into whole blood clots. In one group of clots (nonperfused clots, n1 = 10), access of urokinase to the fibrin network was possible by diffusion only, whereas in the other group (perfused clots, n2 = 10) bulk flow of plasma containing urokinase was instituted through occlusive clots by a pressure difference of 3 .7 kPa (37 cm H2O) across 3 cm long clots with a diameter of 4 mm. It was determined separately that this pressure difference resulted in a volume flow rate of 5.05 ± 2.4 × 10−2 ml/min through occlusive clots. Perfused clots diminished in size significantly in comparison to nonperfused ones already after 20 min (p <0.005). Linear regression analysis of two-dimensional clot sizes measured by MRI showed that the rate of lysis was more than 50-times faster in the perfused group in comparison to the nonperfused group. It was concluded that penetration of the thrombolytic agent into clots by perfusion is much more effective than by diffusion. Our results might have some implications for understanding the differences in lysis of arterial and venous thrombi.

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Urokinase Evaluated with the Experimental Radioactive Embolus

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654164 ◽

1967 ◽

Vol 17 (03/04) ◽

pp. 405-411

Author(s):

M Hume

Keyword(s):

Animal Experiment ◽

Blood Clot ◽

In Vitro Testing ◽

Effective Agent

SummaryUrokinase and urokinase-activated plasmin have been given to the dog and rabbit. A thrombolytic state has been induced. Purified urokinase has induced lysis of the experimental radioactive blood clot embolus in the circulation. Demonstration of effectiveness in this animal experiment is hampered by inhibition of the agents in the circulation to a degree much greater than was noted in previous experiments with streptokinase. In vitro testing indicates that under proper conditions urokinase will be an effective agent in the treatment of human thromboembolism.

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