In Vivo Effect of Titanium Implants with Porous Zinc-Containing Coatings Prepared by Plasma Electrolytic Oxidation Method on Osseointegration in Rabbits

2018 ◽  
Vol 33 (2) ◽  
pp. 298-310 ◽  
Author(s):  
Jing He ◽  
Wei Feng ◽  
Bao-Hong Zhao ◽  
Wei Zhang ◽  
Zeng Lin
Keyword(s):  
Plasma Electrolytic Oxidation ◽  
Titanium Implants ◽  
Oxidation Method ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic

scholarly journals Antibacterial Titanium Implants Biofunctionalized by Plasma Electrolytic Oxidation with Silver, Zinc, and Copper: A Systematic Review

2021 ◽  
Vol 22 (7) ◽  
pp. 3800
Author(s):  
Ingmar A. J. van Hengel ◽  
Melissa W. A. M. Tierolf ◽  
Lidy E. Fratila-Apachitei ◽  
Iulian Apachitei ◽  
Amir A. Zadpoor
Keyword(s):  
Systematic Review ◽  
Antibacterial Activity ◽  
Plasma Electrolytic Oxidation ◽  
Bacterial Load ◽  
Titanium Implants ◽  
Future Research ◽  
Resistant Bacteria ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic ◽  
Cu And Zn

Patients receiving orthopedic implants are at risk of implant-associated infections (IAI). A growing number of antibiotic-resistant bacteria threaten to hamper the treatment of IAI. The focus has, therefore, shifted towards the development of implants with intrinsic antibacterial activity to prevent the occurrence of infection. The use of Ag, Cu, and Zn has gained momentum as these elements display strong antibacterial behavior and target a wide spectrum of bacteria. In order to incorporate these elements into the surface of titanium-based bone implants, plasma electrolytic oxidation (PEO) has been widely investigated as a single-step process that can biofunctionalize these (highly porous) implant surfaces. Here, we present a systematic review of the studies published between 2009 until 2020 on the biomaterial properties, antibacterial behavior, and biocompatibility of titanium implants biofunctionalized by PEO using Ag, Cu, and Zn. We observed that 100% of surfaces bearing Ag (Ag-surfaces), 93% of surfaces bearing Cu (Cu-surfaces), 73% of surfaces bearing Zn (Zn-surfaces), and 100% of surfaces combining Ag, Cu, and Zn resulted in a significant (i.e., >50%) reduction of bacterial load, while 13% of Ag-surfaces, 10% of Cu-surfaces, and none of Zn or combined Ag, Cu, and Zn surfaces reported cytotoxicity against osteoblasts, stem cells, and immune cells. A majority of the studies investigated the antibacterial activity against S. aureus. Important areas for future research include the biofunctionalization of additively manufactured porous implants and surfaces combining Ag, Cu, and Zn. Furthermore, the antibacterial activity of such implants should be determined in assays focused on prevention, rather than the treatment of IAIs. These implants should be tested using appropriate in vivo bone infection models capable of assessing whether titanium implants biofunctionalized by PEO with Ag, Cu, and Zn can contribute to protect patients against IAI.

Inhibitor-Containing Composite Coatings on Mg Alloys: Corrosion Mechanism and Self-Healing Protection

2015 ◽  
Vol 245 ◽  
pp. 89-96 ◽  
Author(s):  
Andrey S. Gnedenkov ◽  
Sergey L. Sinebryukhov ◽  
Dmitry V. Mashtalyar ◽  
Sergey V. Gnedenkov
Keyword(s):  
Plasma Electrolytic Oxidation ◽  
Composite Coatings ◽  
Healing Process ◽  
Corrosion Mechanism ◽  
Self Healing ◽  
Protective Properties ◽  
Oxidation Method ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic ◽  
Electrode Technique

The way of self-healing coating formation at the surface of magnesium alloys by means of plasma electrolytic oxidation method (PEO) with subsequent filling of the obtained layer with inhibitor has been suggested. The electrochemical properties of such coatings have been described in details. The obtained experimental results indicate that the protective properties of the samples with inhibitor-containing coating were increased (IC = 8.6×10–8 A/cm2) in comparison with the samples without coating (5.3×10–5 A/cm2) and the base coating obtained by plasma electrolytic oxidation method (PEO) (3.4×10–7 A/cm2). The local scanning electrochemical methods of surface investigation, notably Scanning Vibrating Electrode Technique (SVET) and Scanning Ion-Selective Electrode Technique (SIET) were used for determining the kinetics and mechanism of the self-healing process. The treatment by the solution containing 8-hydroxyquinoline, which inhibits the corrosion process, enables one to increase the protective properties of the composite coating in 30 times in the corrosion-active environment in comparison with the base PEO-coating and avert the intensive destruction of the material.

scholarly journals Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 229 ◽  
Author(s):  
Lyudmila V. Parfenova ◽  
Elena S. Lukina ◽  
Zulfia R. Galimshina ◽  
Guzel U. Gil’fanova ◽  
Veta R. Mukaeva ◽  
...  
Keyword(s):  
Titanium Implants ◽  
Biologically Active ◽  
Hybrid Molecules ◽  
Electrolytic Oxidation ◽  
Coated Surface ◽  
Plasma Electrolytic ◽  
Chemical Cross Linking ◽  
Significant Attention

Currently, significant attention is attracted to the problem of the development of the specific architecture and composition of the surface layer in order to control the biocompatibility of implants made of titanium and its alloys. The titanium surface properties can be tuned both by creating an inorganic sublayer with the desired morphology and by organic top coating contributing to bioactivity. In this work, we developed a composite biologically active coatings based on hybrid molecules obtained by chemical cross-linking of amino acid bisphosphonates with a linear tripeptide RGD, in combination with inorganic porous sublayer created on titanium by plasma electrolytic oxidation (PEO). After the addition of organic molecules, the PEO coated surface gets nobler, but corrosion currents increase. In vitro studies on proliferation and viability of fibroblasts, mesenchymal stem cells and osteoblast-like cells showed the significant dependence of the molecule bioactivity on the structure of bisphosphonate anchor and the linker. Several RGD-modified bisphosphonates of β-alanine, γ-aminobutyric and ε-aminocaproic acids with BMPS or SMCC linkers can be recommended as promising candidates for further in vivo research.

scholarly journals Author Correction: Plasma Electrolytic Oxidation as a Feasible Surface Treatment for Biomedical Applications: an in vivo study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tárik Ocon Braga Polo ◽  
William Phillip Pereira Silva ◽  
Gustavo Antonio Correa Momesso ◽  
Tiburtino José Lima-Neto ◽  
Stéfany Barbosa ◽  
...  
Keyword(s):  
Surface Treatment ◽  
Plasma Electrolytic Oxidation ◽  
Biomedical Applications ◽  
In Vivo Study ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals Plasma Electrolytic Oxidation as a Feasible Surface Treatment for Biomedical Applications: an in vivo study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tárik Ocon Braga Polo ◽  
William Phillip Pereira Silva ◽  
Gustavo Antonio Correa Momesso ◽  
Tiburtino José Lima-Neto ◽  
Stéfany Barbosa ◽  
...  
Keyword(s):  
Plasma Electrolytic Oxidation ◽  
Immunohistochemical Analysis ◽  
Elisa Test ◽  
Biomechanical Analysis ◽  
Control Surface ◽  
Bone Maturation ◽  
Reverse Torque ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic

Abstract Objectives: In this in vivo animal study, we evaluated the effect of plasma electrolytic oxidation (PEO) coating on the topographic and biological parameters of implants installed in rats with induced osteoporosis and low-quality bones. Materials and methods: In total 44 Wistar rats (Rattus novergicus), 6 months old, were submitted to ovariectomy (OXV group) and dummy surgery (SHAM group). After 90 days, the ELISA test was performed and the ovariectomy effectiveness was confirmed. In each tibial metaphysis, an implant with PEO coating containing Ca2+ and P5+ molecules were installed, and the other tibia received an implant with SLA acid etching and blasting (AC) (control surface). After 42 days, 16 rats from each group were euthanized, their tibias were removed for histological and immunohistochemical analysis (OPG, RANKL, OC and TRAP), as well as reverse torque biomechanics. Data were submitted to One-way ANOVA or Kruskal-Wallis tests, followed by a Tukey post-test; P < 0.05. Histological analyses showed higher bone neoformation values among the members of the PEO group, SHAM and OVX groups. Immunohistochemical analysis demonstrated equilibrium in all groups when comparing surfaces for TRAP, OC and RANKL (P > 0.05), whereas OPG showed higher PEO labeling in the OVX group (P < 0.05). Biomechanical analysis showed higher reverse torque values (N.cm) for PEO, irrespective of whether they were OVX or SHAM groups (P < 0.05). Conclusion: The results indicated that the PEO texturing method favored bone formation and showed higher bone maturation levels during later periods in osteoporotic rats.

Influence of Magnetostatic Interactions on Magnetization Process of Iron-Containing Coatings, Produced Using the Plasma Electrolytic Oxidation Method

2014 ◽  
Vol 215 ◽  
pp. 200-203 ◽  
Author(s):  
Peter V. Kharitonskii ◽  
Anatoly Frolov ◽  
Sergey A. Boev ◽  
Vladimir S. Rudnev ◽  
I.A. Tkachenko ◽  
...  
Keyword(s):  
Magnetic Moment ◽  
Plasma Electrolytic Oxidation ◽  
Magnetic Moments ◽  
Remnant Magnetization ◽  
Magnetization Process ◽  
Magnetostatic Interaction ◽  
Oxidation Method ◽  
Superparamagnetic Particles ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic

In this paper we research the process of magnetization of iron-containing coatings obtained on aluminum and titanium plasma electrolytic oxidation. It is shown that the formation of a remnant magnetic moment mainly determined by the magnetostatic interaction particles (phases). This interaction leads to a decrease of the blocking volume of particles (phases). Thus, a large number of superparamagnetic particles (phases) obtain stable magnetic moments and are involved in creating of the remnant magnetization of the sample.

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