Bone-to-Implant Contact and New Bone Formation Within Human Freeze-Dried Bone Blocks Grafted Over Rabbit Calvaria

2017 ◽  
Vol 32 (4) ◽  
pp. 768-773 ◽  
Author(s):  
Zvi Artzi ◽  
Karen Anavi-Lev ◽  
Avital Kozlovsky ◽  
Liat Chaushu ◽  
Frank Schwarz ◽  
...  
Keyword(s):  
Bone Formation ◽  
New Bone Formation ◽  
Freeze Dried ◽  
Bone To Implant Contact

The effect of new bone formation of titanium mesh and demineralized freeze-dried bone

2004 ◽  
Vol 34 (1) ◽  
pp. 163
Author(s):  
Yun-Ho Lee ◽  
Joon-Bong Park ◽  
Young-Hyuk Kwon ◽  
Yeek Herr ◽  
Chong-Kwan Kim
Keyword(s):  
Bone Formation ◽  
Titanium Mesh ◽  
New Bone Formation ◽  
Freeze Dried

Porous Titanium Membranes Combined with Various Graft Materials Induce Exophytic Bone Formation in Rabbit Calvaria

2006 ◽  
Vol 309-311 ◽  
pp. 427-432 ◽  
Author(s):  
Y. Kim ◽  
Y.H. Kown ◽  
J.B. Park ◽  
J.H. Chung ◽  
H.N. Lim ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Porous Titanium ◽  
Control Group ◽  
Bovine Bone ◽  
Graft Material ◽  
New Bone Formation ◽  
Freeze Dried ◽  
Custom Made ◽  
Human Cancellous Bone

The purpose of this study was to examine if the application of custom-made porous titanium membranes combined with bone graft materials promotes exophytic bone formation in rabbit calvaria. For this purpose, round decorticated calvaria sites were created using a round carbide bur. In the control group, rectangular parallelepiped-shaped porous titanium membranes (RPTMs) were placed on the decorticated sites and fixed with metal pins. In the experimental groups, RPTMs were filled with one of the following bone graft materials prior to fixing with metal pins: bovine bone mineral (BBM), demineralized freeze-dried human cortical bone (DFDB) or freeze-dried human cancellous bone (FDB). Animals were sacrificed at 8 and 12 weeks after surgery, and new bone formation was assessed by histomorphometric as well as statistical analysis. The results indicate that at 8 and 12 weeks, all the experimental groups demonstrated exophytic bone formation. At 12 weeks, DFDB group revealed the most new bone formation (p<0.05) and resorption of grafted materials (p<0.05). On the basis of these findings, we conclude that RPTMs may be used as an augmentation membrane for guided bone regeneration and DFDB as an effective bone-inducing graft material.

Ability of Commercial Demineralized Freeze-Dried Bone Allograft to Induce New Bone Formation

1996 ◽  
Vol 67 (9) ◽  
pp. 918-926 ◽  
Author(s):  
Z. Schwartz ◽  
J.T. Mellonig ◽  
D.L. Carnes ◽  
J. De La Fontaine ◽  
D.L. Cochran ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Allograft ◽  
New Bone Formation ◽  
Freeze Dried

Evaluation of 2 Novel Approaches for Assessing the Ability of Demineralized Freeze-Dried Bone Allograft to Induce New Bone Formation

1999 ◽  
Vol 70 (4) ◽  
pp. 353-363 ◽  
Author(s):  
D.L. Carnes ◽  
J. De La Fontaine ◽  
D.L. Cochran ◽  
J.T. Mellonig ◽  
B. Keogh ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Allograft ◽  
New Bone Formation ◽  
Freeze Dried ◽  
Novel Approaches

scholarly journals Evaluation of equine cortical bone transplantation in a canine fracture model

2011 ◽  
Vol 56 (No. 3) ◽  
pp. 110-118 ◽  
Author(s):  
S.H. Heo ◽  
C.S. Na ◽  
N.S. Kim
Keyword(s):  
Bone Formation ◽  
Single Case ◽  
Bone Transplantation ◽  
Control Group ◽  
Bovine Bone ◽  
Graft Material ◽  
New Bone Formation ◽  
Osteoblast Activity ◽  
Freeze Dried ◽  
Equine Bone

Freeze-dried bovine bone transplantation is commonly used for orthopaedic surgery. Equine bone, which is available in great quantity, can be obtained as easily as bovine bone, and so represents a potential source of bone for transplantation. In the present study freeze-dried equine cortical bones were transplanted into experimentally-induced fibular defects in canines to evaluate xenogenic implantation of equine bone. Cortical bones that had been freed of antigens and defatted with chloroform and methanol were freeze-dried at &ndash;80 &deg;C for preservation of bone morphogenetic protein, sterilized with ethylene oxide gas and stored at room temperature. The experimental osteotomy was performed in a 15 mm-long bilateral region of each proximal metaphyseal fibula. The area of defect in eight beagle dogs (n = 16) received a transplanted freeze-dried equine cortical implant. The control group consisting of two beagles dogs (n = 4) received an autograft of a similar implant. The experiment region was radiographically monitored for bone union and host serum osteocalcin level was determined to assess osteoblast activity every two weeks for 24 weeks. In 14 of the 16 experimental cases, the graft was not associated with new bone formation. Resorption after new bone formation and remodelling with new bone formation each occurred in a single case. The results support the potential of using freeze-dried equine cortical bones as a xenogenic bone graft material in canines.

Ability of Commercial Demineralized Freeze-Dried Bone Allograft to Induce New Bone Formation Is Dependent on Donor Age But Not Gender

1998 ◽  
Vol 69 (4) ◽  
pp. 470-478 ◽  
Author(s):  
Z. Schwartz ◽  
A. Somers ◽  
J.T. Mellonig ◽  
D.L. Carnes ◽  
D.D. Dean ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Allograft ◽  
New Bone Formation ◽  
Donor Age ◽  
Freeze Dried

Effects of Autogenous Tooth Bone Graft and Platelet-Rich Fibrin in Peri-Implant Defects: An Experimental Study in an Animal Model

2020 ◽  
Vol 46 (3) ◽  
pp. 221-226
Author(s):  
Alper Kızıldağ ◽  
Ufuk Tasdemir ◽  
Taner Arabacı ◽  
Canan Aksu Kızıldağ ◽  
Mevlüt Albayrak ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Dental Implants ◽  
Bone Healing ◽  
Bone Defects ◽  
Control Group ◽  
Graft Material ◽  
New Bone Formation ◽  
Platelet Rich Fibrin ◽  
Bone To Implant Contact

The aim of this study was to evaluate the effect of autogenous tooth bone graft (ATBG) combined with platelet-rich fibrin (PRF) on bone healing in rabbit peri-implant osseous defects. Eighteen New Zealand rabbits were divided into 3 groups. Bone defects were prepared in each rabbit, and then an implant cavity was created in the defects. Dental implants were placed, and the peri-implant bone defects were treated with the following 3 methods: no graft material was applied in the control group, bone defects were treated with ATBG in the ATBG group, and bone defects were treated with ATBG combined with PRF in the ATBG+PRF group. After 28 days, the rabbits were sacrificed, and the dental implants with surrounding bone were removed. New bone formation and the percentage of bone-to-implant contact (BIC) were determined with histomorphometric evaluations. New bone formation was significantly higher in the ATBG+PRF group than the control and ATBG groups (P &lt; .05). In addition, BIC was significantly higher in the ATBG+PRF group than in the control and ATBG groups (P &lt; .05). The combination of ATBG with PRF contributed to bone healing in rabbits with peri-implant bone defects.

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