Experimental Evaluation of the Effectiveness of Demineralized Bone Matrix and Collagenated Heterologous Bone Grafts Used Alone or in Combination with Platelet-Rich Fibrin on Bone Healing in Sinus Floor Augmentation

2016 ◽  
pp. e24-e31 ◽  
Author(s):  
Elif Peker ◽  
Inci Karaca ◽  
Benay Yildirim
Keyword(s):  
Bone Healing ◽  
Experimental Evaluation ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Bone Grafts ◽  
Platelet Rich Fibrin ◽  
Sinus Floor Augmentation ◽  
Sinus Floor ◽  
Demineralized Bone

scholarly journals First Human Leucocyte Antigen (HLA) Response and Safety Evaluation of Fibrous Demineralized Bone Matrix in a Critical Size Femoral Defect Model of the Sprague-Dawley Rat

Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3120
Author(s):  
Nicolas Söhling ◽  
Maximilian Leiblein ◽  
Alexander Schaible ◽  
Maren Janko ◽  
Joachim Schwäble ◽  
...  
Keyword(s):  
Bone Healing ◽  
Critical Size ◽  
Demineralized Bone Matrix ◽  
High Surface ◽  
Bone Matrix ◽  
Volume Ratio ◽  
Bone Allograft ◽  
Control Group ◽  
Sprague Dawley ◽  
Demineralized Bone

Treatment of large bone defects is one of the great challenges in contemporary orthopedic and traumatic surgery. Grafts are necessary to support bone healing. A well-established allograft is demineralized bone matrix (DBM) prepared from donated human bone tissue. In this study, a fibrous demineralized bone matrix (f-DBM) with a high surface-to-volume ratio has been analyzed for toxicity and immunogenicity. f-DBM was transplanted to a 5-mm, plate-stabilized, femoral critical-size-bone-defect in Sprague-Dawley (SD)-rats. Healthy animals were used as controls. After two months histology, hematological analyses, immunogenicity as well as serum biochemistry were performed. Evaluation of free radical release and hematological and biochemical analyses showed no significant differences between the control group and recipients of f-DBM. Histologically, there was no evidence of damage to liver and kidney and good bone healing was observed in the f-DBM group. Reactivity against human HLA class I and class II antigens was detected with mostly low fluorescence values both in the serum of untreated and treated animals, reflecting rather a background reaction. Taken together, these results provide evidence for no systemic toxicity and the first proof of no basic immunogenic reaction to bone allograft and no sensitization of the recipient.

Radiologic Evaluation of Putty Versus Powder Form of Demineralized Bone Matrix in Sinus Floor Elevation

2012 ◽  
Vol 38 (4) ◽  
pp. 337-344 ◽  
Author(s):  
Cem Üngör
Keyword(s):  
Maxillary Sinus ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Powder Form ◽  
Panoramic Radiographs ◽  
Sinus Lifting ◽  
Sinus Floor Augmentation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Augmentation

The aim of this study was to evaluate differences in ossification of the 2 forms of demineralized bone matrix (DBM)—putty and powder—radiographically, using digital densitometry on panoramic radiographs in maxillary sinus floor augmentation procedures. Twelve subjects needing bilateral maxillary sinus floor augmentation for the placement of osseointegrated implants were included in this study. The left and right maxillary sinuses were augmented in the same session in each patient using the 2 preferred forms of DBM—putty and powder—during the same session. One sinus was augmented with DBM putty form and the other sinus was augmented with DBM powder form randomly. Every patient had a total of 4 panoramic radiographs taken, preoperatively and in the first, third, and sixth month postoperatively. The densitometry measurements were taken from each step of the aluminium step-wedge, from both sinuses from different points a total of 3 times, and the average of these measurements was calculated. The amount of mineralization in each graft material in every radiograph was clarified by the appearance of a difference in the equivalent aluminium thickness, and the obtained results were statistically evaluated. The results showed that there were no significant differences between two graft materials statistically. These two graft materials could be good alternatives in sinus lifting procedures because of less morbidity, lower price, and good ossification. The results indicate that 2 different types of DBM achieved good ossification in the sinus lifting procedure, and there is not a considerable distinction in these 2 forms.

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