The use of intraoral devices in reducing oral and dental side effects in head and neck cancer patients undergoing radiotherapy – a systematic review.

2021 ◽  
Author(s):  
Suresh Nayar ◽  
Anna Greer ◽  
Ade Mosaku ◽  
Joe Vere
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Side Effects ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Intraoral Devices

The effects of continued smoking in head and neck cancer patients treated with radiotherapy: A systematic review and meta-analysis

2019 ◽  
Vol 135 ◽  
pp. 51-57 ◽  
Author(s):  
Justin Smith ◽  
Domenico Nastasi ◽  
Reece Tso ◽  
Venkat Vangaveti ◽  
Bronia Renison ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Meta Analysis

scholarly journals Circulating MicroRNAs as Prognostic Molecular Biomarkers in Human Head and Neck Cancer: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Shree Ram Lamichhane ◽  
Thanuja Thachil ◽  
Harriet Gee ◽  
Natalie Milic
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Circulating Micrornas

Background. Circulating microRNAs (miRNAs) are potential molecular biomarkers for cancer detection; however, little is known about their prognostic role in head and neck cancer. This current study is aimed at evaluating the role of novel miRNAs in the survival of head and neck cancer patients. Materials and Methods. We performed a systematic literature search using online databases for articles published between December 2006 and February 2019. A meta-analysis was conducted to assess the correlation between miRNA expressions and overall survival (OS) among the selected head and neck cancer studies. After multilevel screening by reviewers, meta-analysis was performed using hazard ratios (HR) and associated 95% confidence interval (CI) of survival to calculate a pooled effect size. Result. A total of 1577 patients across 13 studies were included in the literature review, with 18 miRNAs upregulated and 4 miRNAs downregulated predicting a poor overall survival. The forest plot generated using cumulated survival data resulted in a pooled HR value of 2.943 (95% CI: 2.394-3.618) indicating a strong association of dysregulated miRNA expression with a poor outcome. Only 2 miRNAs—low levels of miR-9 and high levels of miR-483-5p—were observed in two studies, both showing a significant association with overall cancer survival. Conclusion. To our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the prognostic role of circulating miRNAs from blood in head and neck cancer patients. The combined effect estimates a HR across multiple studies and also supports the previous individual findings that an alteration in miRNA expression is highly associated with poor prognosis. This has the potential to use serum and/or plasma miRNAs as biomarkers and become novel tools for predicting the prognosis of head and neck cancer patients in the near future.

scholarly journals Factors associated with depression over time in head and neck cancer patients: A systematic review

2019 ◽  
Vol 28 (6) ◽  
pp. 1159-1183 ◽  
Author(s):  
Laura H.A. Korsten ◽  
Femke Jansen ◽  
Ben J.F. Haan ◽  
Danielle Sent ◽  
Pim Cuijpers ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Factors Associated ◽  
Over Time

scholarly journals Nanoparticle-Based Chemotherapy Formulations for Head and Neck Cancer: A Systematic Review and Perspectives

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1938
Author(s):  
Jefferson Muniz de Lima ◽  
Paulo Rogerio Bonan ◽  
Danyel Elias da Cruz Perez ◽  
Michael Hier ◽  
Moulay A. Alaoui-Jamali ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Side Effects ◽  
Head And Neck ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Basic Research ◽  
Cochrane Central Register ◽  
Level Of Evidence ◽  
Mortality And Morbidity

Head and neck cancer (HNC) is a complex and heterogeneous disease associated with high mortality and morbidity worldwide. Standard therapeutic management of advanced HNC, which is based on radiotherapy often combined with chemotherapy, has been hampered by severe long-term side effects. To overcome these side effects, tumor-selective nanoparticles have been exploited as a potential drug delivery system to improve HNC therapy. A combination of MEDLINE, EMBASE, Cochrane Oral Health Group’s Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov from inception up to June 2020 was used for this systematic review. A total of 1747 published manuscripts were reviewed and nine relevant references were retrieved for analysis, while eight of them were eligible for meta-analysis. Based on these studies, the level of evidence about the efficacy of nanoformulation for HNC therapy on tumor response and adverse side effects (SAE) was low. Even though basic research studies have revealed a greater promise of nanomaterial to improve the outcome of cancer therapy, none of them were translated into clinical benefits for HNC patients. This systematic review summarized and discussed the recent progress in the development of targeted nanoparticle approaches for HNC management, and open-up new avenues for future perspectives.

Tumour response and survival of treatment-naïve head and neck cancer patients treated with nimotuzumab: A systematic review and meta-analysis.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e18083-e18083
Author(s):  
Sundaram Subramanian ◽  
Naresh Somani ◽  
Shyam Ji Rawat ◽  
Sridharan Nithya ◽  
Ashwani Marwah ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Tumour Response ◽  
Treatment Naïve

The effect of exercise therapy in head and neck cancer patients in the treatment of radiotherapy-induced trismus: A systematic review

Oral Oncology ◽  
2015 ◽  
Vol 51 (8) ◽  
pp. 745-750 ◽  
Author(s):  
Anne Scherpenhuizen ◽  
Anne M.A. van Waes ◽  
Luuk M. Janssen ◽  
Ellen M. Van Cann ◽  
Inge Stegeman
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Exercise Therapy ◽  
Neck Cancer

Radiation-induced hypothyroidism in head and neck cancer patients: A systematic review

2011 ◽  
Vol 99 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Marjolein J. Boomsma ◽  
Hendrik P. Bijl ◽  
Johannes A. Langendijk
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Radiation Induced
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