Erratum to McEwen et al. "Diurnal changes and levels of fibrin generation are not altered by continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA). A randomised, placebo-controlled crossover study" (Thromb Haemost 2012; 108: 701–709)

2013 ◽  
Vol 110 (5) ◽  
pp. 1085-1085
Author(s):  
B. J. McEwen ◽  
C. L. Phillips ◽  
M.-C. Morel-Kopp ◽  
B. J. Yee ◽  
D. R. Sullivan ◽  
...  
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Crossover Study ◽  
Obstructive Sleep Apnoea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Sleep Apnoea ◽  
Diurnal Changes ◽  
Obstructive Sleep

Erratum to McEwen et al. "Diurnal changes and levels of fibrin generation are not altered by continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA). A randomised, placebo-controlled crossover study" (Thromb Haemost 2012; 108: 701–709)

2013 ◽  
Vol 110 (11) ◽  
pp. 1085
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Crossover Study ◽  
Obstructive Sleep Apnoea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Treatment Compliance ◽  
Original Data ◽  
Sleep Apnoea ◽  
Diurnal Changes ◽  
Obstructive Sleep

SummaryIn the original article by McEwen BJ, Phillips CL, et al. "Diurnal changes and levels of fibrin generation are not altered by continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA). A randomised, placebo-controlled crossover study. (Thromb Haemost 2012; 108: 701–709) the authors recently realised that a statistical analysis error has resulted in minor data errors in Table 1. They also realised that no data on the Epworth Sleepiness Score (ESS) was listed despite the table legend listing the meaning of ESS.The correct (mean ± SD) baseline data are: AHI (events/h): 37.7 ± 24.4; ODI (events/h): 30.7 ± 22.6; SaO2-T90 (%TST): 5.9 ± 10.1; Min SaO2 (%) 79.3 ± 9.8; ESS 10.2 ± 4.9.The correct (mean ± SEM) CPAP vs Placebo CPAP data are: AHI (events/h): 5.7 ± 1.7 vs 40.2 ± 5.2, p<0.00001; ODI (Events/h): 4.2 ± 1.7 vs 39.6 ± 4.4, p<0.00001; SaO2-T90 (%TST): 0.6 ± 0.3 vs 9.8 ± 2.3, p<0.001; Min SaO2 (%) 90 ± 1.2 vs 79 ± 1.4, p<0.00001; Treatment Compliance (h/night) 4.3 ± 0.4 vs 3.4 ± 0.4, p<0.05; Epworth Sleepiness Score (ESS) 7.4 ± 0.8 vs 8.7 ± 0.7, p<0.05.Although this new data is very similar to the original data, the authors felt it important to correct. Importantly, these errors had no influence on the main coagulation outcomes and study interpretation.

scholarly journals Effects of continuous positive airway pressure on coagulability in obstructive sleep apnoea: a randomised, placebo-controlled crossover study

Thorax ◽  
2012 ◽  
Vol 67 (7) ◽  
pp. 639-644 ◽  
Author(s):  
Craig L Phillips ◽  
Bradley J McEwen ◽  
Marie-Christine Morel-Kopp ◽  
Brendon J Yee ◽  
David R Sullivan ◽  
...  
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Crossover Study ◽  
Obstructive Sleep Apnoea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Sleep Apnoea ◽  
Obstructive Sleep

Diurnal changes and levels of fibrin generation are not altered by continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA)

2012 ◽  
Vol 108 (10) ◽  
pp. 701-709 ◽  
Author(s):  
Marie-Christine Morel-Kopp ◽  
Brendon J. Yee ◽  
David R. Sullivan ◽  
Christopher M. Ward ◽  
Geoffrey H. Tofler ◽  
...  
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Obstructive Sleep Apnoea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Sleep Apnoea ◽  
Temporal Association ◽  
Diurnal Changes ◽  
Cvd Risk ◽  
Maximum Slope ◽  
Obstructive Sleep

SummaryObstructive sleep apnoea (OSA) is associated with increased cardiovascular disease (CVD) risk. In the general population, CVD events peak at 9:00–10:00 AM, associated with diurnal changes in thrombotic potential. However in OSA, these CVD events occur frequently at night. Measuring thrombotic potential across the sleep-wake cycle may provide insight into the temporal association of OSA with CVD. This study aimed to determine diurnal changes in fibrin generation in OSA and whether treatment of OSA with continuous positive airway pressure (CPAP) alters fibrin generation across the sleep-wake cycle. In a randomised placebo-controlled crossover trial, patients with OSA were assigned to two months each of therapeutic CPAP and placebo. After each treatment period, fibrin generation was determined by overall haemostatic potential assay at seven time points over 24 hours (h). Twenty-eight patients (25 men, 3 women) with severe OSA (Apnoea Hypopnoea Index = 37.9 ± 23.9/h, Oxygen Desaturation Index 31.3 ± 22.4/h) completed the study. All parameters, except lag time to fibrin generation, showed significant diurnal changes, both on CPAP and placebo. Compared to 9:00 AM, fibrin generation parameters were significantly lower at midnight and 3:00 AM for overall coagulation potential (OCP), overall haemostasis potential (OHP), maximum optical density, and maximum slope (all p≤0.001). CPAP produced no change in fibrin generation parameters compared to placebo. In severe OSA patients, fibrin generation peaked at 6:00 AM and 9:00 AM rather than during the sleep period (midnight and 3:00 AM). These findings suggest a prothrombotic shift in the morning similar to individuals without OSA. There was no difference between CPAP and placebo on fibrin generation.

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