Response to the Letter: Sleep-Disordered Breathing in Precapillary Pulmonary Hypertension: Is the Prevalence So High? Reference Article: Sleep-Disordered Breathing and Nocturnal Hypoxemia in Precapillary Pulmonary Hypertension: Prevalence, Pathophysiological Determinants and Clinical Consequences by Zheng Z et al.

Respiration ◽  
2021 ◽  
pp. 1-3
Author(s):  
Jens Spiesshoefer ◽  
Simon D. Herkenrath ◽  
Katharina Harre ◽  
Florian Kahles ◽  
Anca Rezeda Florian ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Sleep Disordered Breathing ◽  
Hypertension Prevalence ◽  
Nocturnal Hypoxemia ◽  
Clinical Consequences ◽  
Disordered Breathing

Sleep-Disordered Breathing and Nocturnal Hypoxemia in Precapillary Pulmonary Hypertension: Prevalence, Pathophysiological Determinants, and Clinical Consequences

Respiration ◽  
2021 ◽  
pp. 1-12
Author(s):  
Jens Spiesshoefer ◽  
Simon Herkenrath ◽  
Katharina Harre ◽  
Florian Kahles ◽  
Anca Florian ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Sleep Disordered Breathing ◽  
Central Sleep Apnea ◽  
Apnea Hypopnea Index ◽  
Amino Terminal ◽  
Nocturnal Hypoxemia ◽  
Obstructive Sleep ◽  
Disordered Breathing

<b><i>Background and objective:</i></b> The clinical relevance and interrelation of sleep-disordered breathing and nocturnal hypoxemia in patients with precapillary pulmonary hypertension (PH) is not fully understood. <b><i>Methods:</i></b> Seventy-one patients with PH (age 63 ± 15 years, 41% male) and 35 matched controls were enrolled. Patients with PH underwent clinical examination with assessment of sleep quality, daytime sleepiness, 6-minute walk distance (6MWD), overnight cardiorespiratory polygraphy, lung function, hypercapnic ventilatory response (HCVR; by rebreathing technique), amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels, and cardiac MRI (<i>n</i> = 34). <b><i>Results:</i></b> Prevalence of obstructive sleep apnea (OSA) was 68% in patients with PH (34% mild, apnea-hypopnea index [AHI] ≥5 to &#x3c;15/h; 34% moderate to severe, AHI ≥15/h) versus 5% in controls (<i>p</i> &#x3c; 0.01). Only 1 patient with PH showed predominant central sleep apnea (CSA). Nocturnal hypoxemia (mean oxygen saturation [SpO<sub>2</sub>] &#x3c;90%) was present in 48% of patients with PH, independent of the presence of OSA. There were no significant differences in mean nocturnal SpO<sub>2</sub>, self-reported sleep quality, 6MWD, HCVR, and lung and cardiac function between patients with moderate to severe OSA and those with mild or no OSA (all <i>p</i> &#x3e; 0.05). Right ventricular (RV) end-diastolic (<i>r</i> = −0.39; <i>p</i> = 0.03) and end-systolic (<i>r</i> = −0.36; <i>p</i> = 0.04) volumes were inversely correlated with mean nocturnal SpO<sub>2</sub> but not with measures of OSA severity or daytime clinical variables. <b><i>Conclusion:</i></b> OSA, but not CSA, is highly prevalent in patients with PH, and OSA severity is not associated with nighttime SpO<sub>2</sub>, clinical and functional status. Nocturnal hypoxemia is a frequent finding and (in contrast to OSA) relates to structural RV remodeling in PH.

scholarly journals Precapillary Pulmonary Hypertension and Sleep-Disordered Breathing: Is There a Link?

Respiration ◽  
2016 ◽  
Vol 93 (1) ◽  
pp. 65-77 ◽  
Author(s):  
Robert Thurnheer ◽  
Silvia Ulrich ◽  
Konrad E. Bloch
Keyword(s):  
Pulmonary Hypertension ◽  
Sleep Disordered Breathing ◽  
Disordered Breathing

scholarly journals Correlation of Spirometry, Sleep Disordered Breathing, and Nocturnal Hypoxemia in Severely Obese Subject

CHEST Journal ◽  
2011 ◽  
Vol 140 (4) ◽  
pp. 943A
Author(s):  
Sandeep Chowdhary ◽  
Tom Cloward ◽  
Kevin Shilling ◽  
Wael Berjaoui ◽  
Robert Farney ◽  
...  
Keyword(s):  
Sleep Disordered Breathing ◽  
Obese Subject ◽  
Nocturnal Hypoxemia ◽  
Severely Obese ◽  
Disordered Breathing

Accumulated nocturnal hypoxemia predict arterial endothelial function in patients with sleep-disordered breathing with or without chronic heart failure

2020 ◽  
Vol 35 (6) ◽  
pp. 800-807 ◽  
Author(s):  
Hiroyuki Sawatari ◽  
Akiko Chishaki ◽  
Mari Nishizaka ◽  
Mami Miyazono ◽  
Tomotake Tokunou ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Endothelial Function ◽  
Sleep Disordered Breathing ◽  
Nocturnal Hypoxemia ◽  
Disordered Breathing

SLEEP ARCHITECTURE AND PREVALENCE OF SLEEP-DISORDERED BREATHING IN PATIENTS WITH SCLERODERMA-RELATED PULMONARY HYPERTENSION

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A2147
Author(s):  
Dhawani Pandya ◽  
Joseph Simonson ◽  
Sara Khan ◽  
Harly Greenberg ◽  
Arunabh Talwar
Keyword(s):  
Pulmonary Hypertension ◽  
Sleep Disordered Breathing ◽  
Sleep Architecture ◽  
Disordered Breathing
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