scholarly journals Increased Risk of Meconium-Related Ileus in Extremely Premature Infants Exposed to Antenatal Magnesium Sulfate

Neonatology ◽  
2022 ◽  
pp. 1-9
Author(s):  
Se In Sung ◽  
So Yoon Ahn ◽  
Suk-Joo Choi ◽  
Soo-young Oh ◽  
Cheong-Rae Roh ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Premature Infants ◽  
Odds Ratio ◽  
Neonatal Intensive Care ◽  
Clinical Characteristics ◽  
Surgical Intervention ◽  
Multivariable Analysis ◽  
Period 2 ◽  
Increased Risk ◽  
Fetal Neuroprotection

<b><i>Introduction:</i></b> We experienced an increased incidence of meconium-related ileus (MRI) in extremely premature infants (EPIs) while adopting the antenatal magnesium sulfate (MgSO<sub>4</sub>) protocol for fetal neuroprotection in our neonatal intensive care unit. This study aimed to test whether antenatal MgSO<sub>4</sub> use was associated with increased risk of MRI in EPIs. <b><i>Methods:</i></b> The incidences of complicated MRI requiring aggressive enema or surgical intervention and other intestinal complications were compared among period 1 (January 2012–December 2013, <i>n</i> = 79), before adoption of the antenatal MgSO<sub>4</sub> protocol for fetal neuroprotection; period 2 (January 2014–March 2016, <i>n</i> = 72), when the protocol was adopted; and period 3 (April 2016–September 2018, <i>n</i> = 75), when the protocol was temporarily withdrawn due to concern regarding intestinal complications in EPIs. <b><i>Results:</i></b> Despite similar baseline clinical characteristics among infants across the study periods, the MRI and MRI with surgical treatment incidences were higher in period 2 than those in periods 1 and 3 (13% vs. 8% and 6%, <i>p</i> = 0.391, and 11% vs. 0% and 1%, <i>p</i> = 0.001, respectively). In multivariable analysis, exposure to antenatal MgSO<sub>4</sub> independently increased the risk of MRI (adjusted odds ratio, 3.8; 95% confidence interval, 1.4, 10.6). <b><i>Conclusion:</i></b> Antenatal MgSO<sub>4</sub> may increase the risk of MRI, frequently requiring surgical intervention, in EPIs with a gestational age of 25 weeks or less.

scholarly journals Antenatal magnesium sulfate treatment and risk of necrotizing enterocolitis in preterm infants born at less than 32 weeks of gestation

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ji Young Hong ◽  
Jee Youn Hong ◽  
Yun-Sun Choi ◽  
Yoo-Min Kim ◽  
Ji-Hee Sung ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Necrotizing Enterocolitis ◽  
Retrospective Cohort ◽  
Treatment Protocol ◽  
Period 2 ◽  
Time Period ◽  
Increased Risk ◽  
Significant Difference ◽  
Study Population ◽  
Fetal Neuroprotection

AbstractAntenatal magnesium sulfate (MgSO4) treatment is widely used for fetal neuroprotection in women at risk of preterm delivery. However, some studies have recently suggested that in utero MgSO4 exposure is associated with an increased risk of necrotizing enterocolitis (NEC). This study aimed to investigate the association between antenatal MgSO4 treatment and risk of NEC. This retrospective cohort study included 756 infants born at 24–31 weeks’ gestation. Subjects were classified into three groups: period 1, when MgSO4 treatment protocol for fetal neuroprotection was not adopted (n = 267); period 2, when the protocol was adopted (n = 261); and period 3, when the protocol was withdrawn because of concern of risk of NEC (n = 228). Rates of NEC (≥ stage 2b) were analyzed according to time period and exposure to antenatal MgSO4. Significant difference in the rate of NEC was not found across the three time periods (2.6% vs. 6.5% vs. 4.8% in periods 1, 2 and 3, respectively, p = 0.103). The rate of NEC was comparable between the infants unexposed and exposed to antenatal MgSO4 (5.1% vs. 3.6%, p = 0.369). These results showed that antenatal MgSO4 treatment was not associated with risk of NEC in our study population.

Peripheral Nerve Injury during Abdominal-Pelvic Surgery: Analysis of the National Surgical Quality Improvement Program Database

2017 ◽  
Vol 83 (11) ◽  
pp. 1214-1219 ◽  
Author(s):  
Christopher J.D. Wallis ◽  
Sarah Peltz ◽  
James Byrne ◽  
Jamie Kroft ◽  
Paul Karanicolas ◽  
...  
Keyword(s):  
Quality Improvement ◽  
Peripheral Nerve Injury ◽  
Odds Ratio ◽  
Open Surgery ◽  
Operative Time ◽  
Multivariable Analysis ◽  
Improvement Program ◽  
Surgical Quality ◽  
Increased Risk ◽  
Preventable Complication

Peripheral nerve injury (PNI) is a rare but preventable complication of surgery. We sought to assess whether the use of minimally invasive surgery (MIS) affects the occurrence of PNI. Using the American College of Surgeons National Surgical Quality Improvement Program database, we examined rates of PNI among patients undergoing appendectomy, hysterectomy, colectomy, or radical prostatectomy between 2005 and 2012. We assessed the effect of MIS, as compared with open surgery, on PNI occurrence using logistic regression. Among 297,532 patients, of whom 175,884 (59.1%) underwent MIS, the rate of PNI was 0.03 per cent. Forty-four patients treated using MIS had PNI (0.03%) as compared with 63 who underwent open surgery (0.05%; P = 0.0002). There was a significant decrease in the proportion of surgeries resulting in PNI (P < 0.0001) over time. In univariate analysis, MIS was associated with a decreased occurrence of PNI (odds ratio 0.48, 95% confidence interval 0.33–0.71), but this became nonsignificant on multivariable analysis (odds ratio 0.71, 95% confidence interval 0.47–1.09). Increased operative time and smoking status were the only factors independently associated with an increased risk of PNI on multivariable analysis. MIS techniques during common abdominal-pelvic surgeries do not appear to increase the risk of PNI. Prolonged operative time and smoking are independently associated with an increased risk of PNI. Quality improvement initiatives to increase awareness of PNI and identify patients at increased risk of this preventable complication should be considered.

scholarly journals An analysis of tumor-related potential spinal column instability (Spine Instability Neoplastic Scores 7–12) eventually requiring surgery with a 1-year follow-up

2021 ◽  
Vol 50 (5) ◽  
pp. E6
Author(s):  
Enrique Vargas ◽  
Dennis T. Lockney ◽  
Praveen V. Mummaneni ◽  
Alexander F. Haddad ◽  
Joshua Rivera ◽  
...  
Keyword(s):  
Logistic Regression ◽  
San Francisco ◽  
Surgical Intervention ◽  
Nonoperative Management ◽  
Multivariable Analysis ◽  
Spinal Instability ◽  
Karnofsky Performance Scale ◽  
Surgery Group ◽  
Increased Risk

OBJECTIVE Within the Spine Instability Neoplastic Score (SINS) classification, tumor-related potential spinal instability (SINS 7–12) may not have a clear treatment approach. The authors aimed to examine the proportion of patients in this indeterminate zone who later required surgical stabilization after initial nonoperative management. By studying this patient population, they sought to determine if a clear SINS cutoff existed whereby the spine is potentially unstable due to a lesion and would be more likely to require stabilization. METHODS Records from patients treated at the University of California, San Francisco, for metastatic spine disease from 2005 to 2019 were retrospectively reviewed. Seventy-five patients with tumor-related potential spinal instability (SINS 7–12) who were initially treated nonoperatively were included. All patients had at least a 1-year follow-up with complete medical records. A univariate chi-square test and Student t-test were used to compare categorical and continuous outcomes, respectively, between patients who ultimately underwent surgery and those who did not. A backward likelihood multivariate binary logistic regression model was used to investigate the relationship between clinical characteristics and surgical intervention. Recursive partitioning analysis (RPA) and single-variable logistic regression were performed as a function of SINS. RESULTS Seventy-five patients with a total of 292 spinal metastatic sites were included in this study; 26 (34.7%) patients underwent surgical intervention, and 49 (65.3%) did not. There was no difference in age, sex, comorbidities, or lesion location between the groups. However, there were more patients with a SINS of 12 in the surgery group (55.2%) than in the no surgery group (44.8%) (p = 0.003). On multivariate analysis, SINS > 11 (OR 8.09, CI 1.96–33.4, p = 0.004) and Karnofsky Performance Scale (KPS) score < 60 (OR 0.94, CI 0.89–0.98, p = 0.008) were associated with an increased risk of surgery. KPS score was not correlated with SINS (p = 0.4). RPA by each spinal lesion identified an optimal cutoff value of SINS > 10, which were associated with an increased risk of surgical intervention. Patients with a surgical intervention had a higher incidence of complications on multivariable analysis (OR 2.96, CI 1.01–8.71, p = 0.048). CONCLUSIONS Patients with a mean SINS of 11 or greater may be at increased risk of mechanical instability requiring surgery after initial nonoperative management. RPA showed that patients with a KPS score of 60 or lower and a SINS of greater than 10 had increased surgery rates.

scholarly journals Antenatal Magnesium Sulfate Exposure and Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants

2019 ◽  
Vol 09 (04) ◽  
pp. e353-e356 ◽  
Author(s):  
Amna Qasim ◽  
Sunil K. Jain ◽  
Ashraf M. Aly
Keyword(s):  
Patent Ductus Arteriosus ◽  
Magnesium Sulfate ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Group Analysis ◽  
Matched Group ◽  
Increased Risk ◽  
Significant Difference ◽  
Baseline Characteristics ◽  
Patent Ductus

Abstract Objective The use of antenatal magnesium sulfate (MgSO4) has been associated with neuroprotective effects. One of its' proposed mechanisms of action includes antagonism of calcium channels. Calcium influx is important for closure of ductus arteriosus. We hypothesized that antenatal MgSO4 exposure may be associated with an increased risk of hemodynamically significant patent ductus arteriosus (HsPDA) in premature infants (PI). Study Design A prospective cohort study conducted in two parts. PI (< 32 weeks and < 1,500 g) were recruited (n = 105). All infants had Echocardiograph (ECHO; within 3 days) and blood samples drawn at the same time for B-type natriuretic peptide (BNP; part 1) and NTproBNP (N-terminal pro BNP; part 2) measurements. HsPDA was defined as a PDA diameter > 1.5 mm and BNP levels > 40 pg/mL or NTproBNP > 10,200 pg/mL. Infants were divided into two groups based on antenatal MgSO4 exposure. Data were analyzed using SPSS 23. Difference in baseline characteristics and antenatal steroid use in the two groups was analyzed. A matched group analysis was performed to adjust for the difference in the numbers between the two groups. A p-value < 0.05 was considered significant. Results There was no significant difference seen in baseline characteristics or use of antenatal steroids in exposed versus unexposed (n = 95 vs. n = 10). There was a significant negative correlation between antenatal MgSO4 exposure and HsPDA in PI (p ≤ 0.05). However, this association was not significant after matched group analysis. Conclusion Antenatal MgSO4 exposure is not associated with an increased risk of HsPDA. It may be associated with a decreased likelihood of HsPDA.

Abstract TP33: Early Recurrent Stroke and Systemic Embolism After Mechanical Thrombectomy: The Effect of Post-Treatment Intracranial Hemorrhage

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Junpei Koge ◽  
Kanta Tanaka ◽  
Takeshi Yoshimoto ◽  
Masayuki Shiozawa ◽  
Hiroshi Yamagami ◽  
...  
Keyword(s):  
Intracranial Hemorrhage ◽  
Odds Ratio ◽  
Mechanical Thrombectomy ◽  
Recurrent Stroke ◽  
Multivariable Analysis ◽  
Early Period ◽  
Reperfusion Therapy ◽  
Systemic Embolism ◽  
Multivariable Logistic Regression Model ◽  
Increased Risk

Background and purpose: There are risks of recurrent stroke and systemic embolism during the early period after mechanical thrombectomy (MT) especially in patients with hemorrhagic transformation because of delayed initiation of anticoagulants. We assessed the rate of early recurrent embolism (ERE) after MT and the effect of intracranial hemorrhage on ERE. Methods: Patients who underwent MT for acute ischemic stroke in our institution between January 2014 and July 2019 were retrospectively reviewed. ERE was defined as symptomatic recurrent stroke and systemic embolism within 14 days after MT. A multivariable logistic regression model with prespecified covariates including anticoagulants within 48 hours after MT was constructed to determine the association between ERE and parenchymal hemorrhage (PH) within 36 hours (SITS-MOST definition). Adjustment for differences in baseline characteristics between patients with and without PH was performed using the inverse probability of treatment weighting (IPTW). Results: A total of 300 patients (mean age, 75.4 years; female patients, 49%; median baseline National Institutes of Health Stroke Scale score, 18 [IQR, 12-25]) were included. ERE was observed in 12 of 300 patients (8 strokes and 4 systemic embolisms; 4.0%; 95% confidence interval [CI], 2.3 to 9.3). The median time from MT to ERE was 6.5 days (IQR, 3-8) and no ERE occurred before PH. Patients with PH were not likely to be initiated anticoagulants within 48 hours after MT (41 % vs. 77%, p < 0.01). In multivariable analysis, PH was significantly associated with an increased risk of ERE (unweighted odds ratio, 5.61; 95% CI, 1.25 to 25.27, p = 0.025). After weighting for IPTW, PH remained an independent predictor of ERE (weighted odds ratio 6.20, 95% CI, 1.05 to 36.57, p = 0.044). Conclusions: ERE occurred in about 4% of patients after the MT. Our results reveal a dilemma that intracranial hemorrhage after reperfusion therapy may increase the risk of recurrent embolism.

Pulmonary Embolism in Patients with COVID-19: Comparison between Different Care Settings

2021 ◽  
Author(s):  
Giacomo Buso ◽  
Lucia Mazzolai ◽  
José Antonio Rueda-Camino ◽  
Carmen Fernández-Capitán ◽  
David Jiménez ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Major Bleeding ◽  
Odds Ratio ◽  
Clinical Characteristics ◽  
Multivariable Analysis ◽  
Outpatient Setting ◽  
Full Spectrum ◽  
First 90 Days ◽  
Acute Pe

AbstractThe clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) who develop pulmonary embolism (PE) in the full spectrum of patient care settings need to be elucidated. The aim of this study was to compare the clinical characteristics, treatment, and 90-day outcomes in patients diagnosed with PE while recovering from COVID-19 in the outpatient setting versus those who were diagnosed with PE while being hospitalized with COVID-19. Data from the international Registro Informatizado de Enfermedad TromboEmbólica (RIETE) registry were used. The major study outcomes were all-cause death, major bleeding, and venous thromboembolism (VTE) recurrences during the first 90 days after PE. From March 2020 to March 2021, 737 patients with COVID-19 experienced acute PE. Of these, 340 (46%) were recovering from COVID-19 as outpatients (267 patients who had been treated at home for COVID-19 and 73 discharged after being hospitalized with COVID-19). Compared with inpatients with COVID-19, those recovering in the outpatient setting upon PE were less likely to be men (odds ratio [OR]: 0.54; 95% confidence interval [CI]: 0.40–0.72) and less likely to have hypertension (OR: 0.55; 95% CI: 0.41–0.74) or diabetes (OR: 0.51; 95% CI: 0.33–0.76). At 90-day follow-up, eight patients (none recovering from COVID-19 as outpatient vs. 2.4% of inpatients with COVID-19) developed recurrent VTE, 34 (1.9 vs. 7.9%) had major bleeding, and 128 (10 vs. 24%) died. On multivariable analysis, inpatients with COVID-19 were at a higher risk of major bleeding (adjusted hazard ratio [HR]: 6.80; 95% CI: 1.52–30.4) or death (adjusted HR: 2.24; 95% CI: 1.40–3.58). In conclusion, using a large multinational registry of patients with COVID-19 who experienced PE, thromboembolic episodes occurring in those recovering from COVID-19 as outpatients were associated with less ominous outcomes than inpatients with COVID-19.

scholarly journals Clinical Results of the Implementation of a Breast Milk Bank in Premature Infants (Under 37 Weeks) at the Hospital Universitario del Valle 2018–2020

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2187
Author(s):  
Javier Torres-Muñoz ◽  
Carlos Alberto Jimenez-Fernandez ◽  
Jennifer Murillo-Alvarado ◽  
Sofia Torres-Figueroa ◽  
Juan Pablo Castro
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Premature Infants ◽  
Odds Ratio ◽  
Neonatal Intensive Care ◽  
Clinical Results ◽  
Human Breast Milk ◽  
Milk Bank ◽  
Exploratory Data ◽  
Milk Banks

Breast milk is widely recognized as the best source of nutrition for both full term and premature babies. We aimed to identify clinical results of the implementation of a breast milk bank for premature infants under 37 weeks in a level III hospital. 722 neonates under 37 weeks, hospitalized in the Neonatal intensive care unit (ICU), who received human breast milk from the institution’s milk bank 57% (n = 412) vs. mixed or artificial 32% (n = 229), at day 7 of life. An exploratory data analysis was carried out. Measures of central tendency and dispersion were used, strength of association of odds ratio (OR) and its confidence intervals (95% confidence interval (CI)). 88.5% had already received human milk before day 7 of life. Those who received human milk, due to their clinical condition, had 4 times a greater chance of being intubated (OR 4.05; 95% CI 1.80–9.11). Starting before day 7 of life decreases the opportunity to develop necrotizing enterocolitis by 82% (adjusted odds ratio (ORa) 0.18; 95% CI 0.03–0.97), intraventricular hemorrhage by 85% (ORa 0.15; 95% CI 0.06–0.45) and sepsis by 77% (ORa 0.23; 95% CI 0.15–0.33). Receiving human milk reduces the probability of complications related to prematurity, evidencing the importance that breast milk banks play in clinical practice.

scholarly journals High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Carolina Palamin Buonafine ◽  
Beatriz Nobre Monteiro Paiatto ◽  
Fabyano Bruno Leal ◽  
Samantha Faria de Matos ◽  
Camila Ohomoto de Morais ◽  
...  
Keyword(s):  
Latin America ◽  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Medical Condition ◽  
Multivariable Analysis ◽  
Sao Paulo ◽  
University Hospital ◽  
São Paulo ◽  
Ocular Pain ◽  
Increased Risk

Abstract Background Brazil became the epicenter of the COVID-19 pandemic in Latin America since May 2020, reporting the highest number of cases and deaths in the region. Healthcare workers (HCWs) are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of HCWs with COVID-19 symptoms. Methods Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among HCWs with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results Overall, 125 (42.37%) of 295 symptomatic HCWs tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (95% CI 15.9–60.3%) in the second week to 55.9% (95% CI 43.2–68.6%) in the sixth week, reaching a plateau (38–46%) thereafter. Median (SD) age was 34.2 (9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariable analysis, using logistic regression, anosmia (adjusted OR 4.4 95% CI 2.21–8.74) and ocular pain (adjusted OR 1.95 95% CI 1.14–3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) HCWs were hospitalized (seven were male) and 2 (1.6%) died. Conclusions The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

scholarly journals Risk stratification of patients undergoing transvenous lead extraction with the ELECTRa Registry Outcome Score (EROS): an ESC EHRA EORP European lead extraction ConTRolled ELECTRa registry analysis

EP Europace ◽  
2021 ◽  
Author(s):  
Baldeep S Sidhu ◽  
Salma Ayis ◽  
Justin Gould ◽  
Mark K Elliott ◽  
Vishal Mehta ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Surgical Repair ◽  
Surgical Intervention ◽  
Significant Risk ◽  
Lead Extraction ◽  
Major Complications ◽  
Outcome Score ◽  
Increased Risk ◽  
Procedural Complications ◽  
Registry Analysis

Abstract Aims Transvenous lead extraction is associated with a significant risk of complications and identifying patients at highest risk pre-procedurally will enable interventions to be planned accordingly. We developed the ELECTRa Registry Outcome Score (EROS) and applied it to the ELECTRa registry to determine if it could appropriately risk-stratify patients. Methods and results EROS was devised to risk-stratify patients into low risk (EROS 1), intermediate risk (EROS 2), and high risk (EROS 3). This was applied to the ESC EORP European Lead Extraction ConTRolled ELECTRa registry; 57.5% EROS 1, 31.8% EROS 2, and 10.7% EROS 3. Patients with EROS 3 or 2 were significantly more likely to require powered sheaths and a femoral approach to complete procedures. Patients with EROS 3 were more likely to suffer procedure-related major complications including deaths (5.1 vs. 1.3%; P &lt; 0.0001), both intra-procedural (3.5 vs. 0.8%; P = 0.0001) and post-procedural (1.6 vs. 0.5%; P = 0.0192). They were more likely to suffer post-procedural deaths (0.8 vs. 0.2%; P 0.0449), cardiac avulsion or tear (3.8 vs. 0.5%; P &lt; 0.0001), and cardiovascular lesions requiring pericardiocentesis, chest tube, or surgical repair (4.6 vs. 1.0%; P &lt; 0.0001). EROS 3 was associated with procedure-related major complications including deaths [odds ratio (OR) 3.333, 95% confidence interval (CI) 1.879–5.914; P &lt; 0.0001] and all-cause in-hospital major complications including deaths (OR 2.339, 95% CI 1.439–3.803; P = 0.0006). Conclusion EROS successfully identified patients who were at increased risk of significant procedural complications that require urgent surgical intervention.

scholarly journals Vertically transmitted infections and extrauterine growth restriction in preterm neonates: a new risk factor

2021 ◽  
Vol 21 (1) ◽  
pp. 107-115
Author(s):  
Verônica Cheles Vieira ◽  
Raquel Cristina Gomes Lima ◽  
Daiane Borges Queiroz ◽  
Danielle Souto de Medeiros
Keyword(s):  
Premature Infants ◽  
Gestational Age ◽  
Neonatal Intensive Care ◽  
Positive Association ◽  
Final Analysis ◽  
Growth Restriction ◽  
Preterm Neonates ◽  
Clinical Practices ◽  
Increased Risk ◽  
Extrauterine Growth Restriction

Abstract Objectives: to investigate the association between Vertically Transmitted Infections (VTI) and Extrauterine Growth Restriction (EUGR) among premature infants in Neonatal Intensive Care Units (NICU). Methods: part of a large non-concurrent cohort study with medical records analysis. We evaluated EUGR in premature infants at a gestational age at birth of > 32 weeks and <36 weeks and presented a corrected gestational age of 36 completed weeks during a 27-day birth follow-up. Premature infants with major congenital anomalies were excluded. We analyzed associations among EUGR, VTI and covariables related to maternal disease, birth characteristics, perinatal morbidities and clinical practices. Results: out of the 91 premature infants, 59.3% (CI95%=48.9-69.0%) developed EUGR. VTI were observed in 4.4%o of the population; all premature infants affected by VTI had EUGR. The VTI found were syphilis, cytomegalovirus disease and toxoplasmosis. The final analysis has showed a positive association between VTI and EUGR (RR=1.57; CI95%o=1.07-2.30); the female covariables (RR=1.50; CI95%=1.11-2.02), moderate premature classification (RR=1.41; CI95%=1.06-1.87) and small for gestational age (RR=2.69; CI95% 1.853.90) have also influenced this outcome. Conclusion: this study revealed VTI as an important morbidity factor, with impact on the increased risk of EUGR between premature infants affected by these diseases.

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