scholarly journals Seroprevalence, genotyping and monitoring of hepatitis C viral loads in patients on antivirals in Burkina Faso

Intervirology ◽  
2021 ◽  
Author(s):  
Edwige T. Yelemkoure ◽  
Albert T. Yonli ◽  
Hermann K. Sombié ◽  
Issoufou Tao ◽  
Abdou Azaque Zouré ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Burkina Faso ◽  
Viral Loads

scholarly journals Hepatitis C virus genotypes: A plausible association with viral loads

2013 ◽  
Vol 56 (4) ◽  
pp. 384 ◽  
Author(s):  
Usman Hassan ◽  
SalmaGhulam Nabi ◽  
Ghazal Zaffar ◽  
NadeemIslam Sheikh ◽  
Khalid Hassan
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Viral Loads ◽  
Virus Genotypes ◽  
Hepatitis C Virus Genotypes

Symptoms Associated with HIV and AIDS

2010 ◽  
Author(s):  
Harold W. Goforth ◽  
Mary Ann Cohen
Keyword(s):  
Hepatitis C ◽  
Opportunistic Infections ◽  
Evidence Base ◽  
Chronic Illnesses ◽  
Hiv And Aids ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Specific Symptom ◽  
Viral Loads ◽  
End Stage

Many persons with HIV and AIDS have symptoms that are unrelated to underlying psychiatric disorders but may masquerade as such. These symptoms may include insomnia, fatigue, nausea, or other troubling symptoms, and often result in suffering for patients, their families, and loved ones. The symptoms are common throughout the course of HIV and AIDS, from onset of infection to late-stage and end-stage AIDS. They need to be addressed whenever they occur and not only as part of end-of-life care. We present protocols to ameliorate or eliminate these symptoms and alleviate suffering. Fatigue is one of the most prevalent but underreported and undertreated aspects of HIV disease. The prevalence of fatigue in an HIV population has been estimated to affect at least 50% of seropositive individuals (Breitbart et al., 1998) and may affect up to 80% of the population. Darko and colleagues (1992) found that HIV-seropositive individuals were more fatigued, required more sleep and daytime naps, and showed less alert morning functioning than did persons who are HIV-seronegative. While the symptom of fatigue may fluctuate with increasing viral loads, there is no evidence base for a consistent correlation between fatigue and viral load. Fatigue is a pseudo-specific symptom common to a variety of disabilities found in an HIV population, and it has been linked to a variety of other AIDS-related disabilities including pain, anemia, impaired physical function, psychological distress, and depression. Hormonal alterations, such as those in testosterone and thyroxin, that occur in the context of HIV infection are also common in this group. While these findings are further discussed in Chapter 10, it is worth noting here that they can contribute substantially to tiredness and fatigue in this population. Other sources of fatigue include multimorbid chronic illnesses (opportunistic infections and cancers, chronic renal insufficiency, hepatitis C and other hepatic illnesses, and chronic obstructive pulmonary disease [COPD]) and some of their treatments (notably interferon/ribavirin for hepatitis C and cancer chemotherapy). Substances such as recreational drugs, nicotine, and caffeine are also factors in HIV-related fatigue.

scholarly journals Comparison of Hepatitis C Viral Loads in Patients with or without Coinfection with Different Genotypes

2004 ◽  
Vol 11 (2) ◽  
pp. 433-435 ◽  
Author(s):  
Alejandro Schijman ◽  
Rodney Colina ◽  
Sergey Mukomolov ◽  
Olga Kalinina ◽  
Laura García ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Loads ◽  
Chronic Hepatitis C Patients

ABSTRACT Hepatitis C virus genotyping was assessed for 257 chronic hepatitis C patients with viral loads above 1,000 IU/ml. Twelve patients were coinfected with more than one genotype. Their median viral loads did not differ significantly from those observed for monoinfected patients, which in turn did not vary significantly among different genotypes.

scholarly journals Presence and Predictors of Hepatitis C Virus RNA in the Semen of Homeless Men

2002 ◽  
Vol 4 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Adeline Nyamathi ◽  
Wendie A. Robbins ◽  
John L. Fahey ◽  
Dorothy Wiley ◽  
Vyacheslav A. Pekler ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sexual Transmission ◽  
Hcv Rna ◽  
Behavioral Risk ◽  
Methamphetamine Use ◽  
Viral Loads ◽  
Homeless Men ◽  
Virus Rna ◽  
Increase Risk

Although the possibility of sexual transmission of the hepatitis C virus (HCV) remains controversial, little is known of the associations of positive semen specimens with potential demographic and behavioral risk factors. Knowledge of these predictors may suggest factors that increase risk of HCV RNA in the semen. Semen and blood from 80 HCV-infected homeless men were evaluated for the presence ofHCVRNA by means of branch DNA and transcription-mediated amplification analyses. Associations of selected demographic and behavioral characteristics of the participants with presence or absence of HCV in their semen were also assessed. HCV RNA was detected in the semen of 36% of the sample. Associations were found with HCV RNA in semen and older age, higher viral loads of HCV in blood, current alcohol and lifetime methamphetamine use, and having been vaccinated for the hepatitis B virus. Findings suggest that sexual transmission of HCV is plausible and shed light on the need to conduct more in-depth investigations.

The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C

2011 ◽  
Vol 130 (6) ◽  
pp. 1470-1475 ◽  
Author(s):  
Hans-Dieter Nischalke ◽  
Martin Coenen ◽  
Cordula Berger ◽  
Katharina Aldenhoff ◽  
Tobias Müller ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Toll Like Receptor ◽  
Viral Loads ◽  
Toll Like Receptor 2

scholarly journals Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

2011 ◽  
Vol 55 (8) ◽  
pp. 3854-3860 ◽  
Author(s):  
Steven S. Carroll ◽  
Kenneth Koeplinger ◽  
Marissa Vavrek ◽  
Nanyan Rena Zhang ◽  
Laurence Handt ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sustained Viral Response ◽  
Pegylated Interferon ◽  
Nucleoside Triphosphate ◽  
Current Standard ◽  
Viral Loads ◽  
Antiviral Efficacy ◽  
Oral And Intravenous Dosing

ABSTRACTHepatitis C virus (HCV) infects an estimated 170 million individuals worldwide, and the current standard of care, a combination of pegylated interferon alpha and ribavirin, is efficacious in achieving sustained viral response in ∼50% of treated patients. Novel therapies under investigation include the use of nucleoside analog inhibitors of the viral RNA-dependent RNA polymerase. NM283, a 3′-valyl ester prodrug of 2′-C-methylcytidine, has demonstrated antiviral efficacy in HCV-infected patients (N. Afdhal et al., J. Hepatol.46[Suppl. 1]:S5, 2007; N. Afdhal et al., J. Hepatol.44[Suppl. 2]:S19, 2006). One approach to increase the antiviral efficacy of 2′-C-methylcytidine is to increase the concentration of the active inhibitory species, the 5′-triphosphate, in infected hepatocytes. HepDirect prodrug technology can increase intracellular concentrations of a nucleoside triphosphate in hepatocytes by introducing the nucleoside monophosphate into the cell, bypassing the initial kinase step that is often rate limiting. Screening for 2′-C-methylcytidine triphosphate levels in rat liver after oral dosing identified 1-[3,5-difluorophenyl]-1,3-propandiol as an efficient prodrug modification. To determine antiviral efficacyin vivo, the prodrug was administered separately via oral and intravenous dosing to two HCV-infected chimpanzees. Circulating viral loads declined by ∼1.4 log10IU/ml and by >3.6 log10IU/ml after oral and intravenous dosing, respectively. The viral loads rebounded after the end of dosing to predose levels. The results indicate that a robust antiviral response can be achieved upon administration of the prodrug.

Association of mutations in two PKR binding domains of hepatitis C virus genotype 3A and viral loads

2003 ◽  
Vol 38 ◽  
pp. 141-142
Author(s):  
Y. Fukuda ◽  
I. Nakano ◽  
Y. Katano ◽  
H. Toyoda ◽  
S. Yokozaki ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Genotype ◽  
Viral Loads ◽  
Binding Domains ◽  
Genotype 3A
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