scholarly journals Low-intensity ultrasound as a novel strategy to improve the cytotoxic effect of oncolytic reovirus on colorectal cancer model cells

Intervirology ◽  
2021 ◽  
Author(s):  
Negar Sharifi ◽  
Hoorieh Soleimanjahi ◽  
Manijeh Mokhtari-Dizaji ◽  
Razieh Sadat Banijamali ◽  
Maliheh Elhamipour ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cytotoxic Effect ◽  
Cancer Model ◽  
Low Intensity ◽  
Low Intensity Ultrasound ◽  
Novel Strategy

Enhanced cytotoxic effect of Ara-C by low intensity ultrasound to HL-60 cells

2000 ◽  
Vol 149 (1-2) ◽  
pp. 189-194 ◽  
Author(s):  
Katsuro Tachibana ◽  
Toshiki Uchida ◽  
Kazuo Tamura ◽  
Haruhiko Eguchi ◽  
Nobuya Yamashita ◽  
...  
Keyword(s):  
Cytotoxic Effect ◽  
Low Intensity ◽  
Low Intensity Ultrasound

Laminin 521 Modulates the Сytotoxic Effect of 5-Fluorouracil on Colorectal Cancer HT29 Cells

2019 ◽  
Vol 35 (6) ◽  
pp. 73-79
Author(s):  
A. Turchinovich ◽  
I.M. Tsypina ◽  
V.G. Zgoda ◽  
S.V. Nikulin ◽  
D.V. Maltseva
Keyword(s):  
Colorectal Cancer ◽  
Cytotoxic Effect ◽  
Mechanisms Of Action ◽  
Ht29 Cell ◽  
Β1 Integrin ◽  
Russian Science ◽  
Apoptotic Gene ◽  
Ht29 Cells ◽  
First Time ◽  
Ht29 Cell Line

The cytotoxic effect of 5-fluorouracil (5FU) and regorafenib (RF)-drugs with different mechanisms of action used to treat colorectal cancer-on the HT29 cell line when cultured on plastic and laminin 521 (LM-521) has been studied. It was shown for the first time that LM-521 can increase the sensitivity of tumor cells to 5FU. Based on the analysis of the transcriptome and proteome, a possible mechanism of the observed effect of LM-521 on HT29 cell viability was proposed. The interaction of β1-containing integrins on the cell surface with LM-521 can activate the FAK/PI3K/Akt signaling pathways, promote phosphorylation of the YAP transcription coactivator and its binding to a complex with the 14-3-3σ protein. The formation of such complex leads to the YAP retention in the cytoplasm, prevents its transport to the nucleus and the activation of anti-apoptotic gene transcription. apoptosis, β1 integrin, colorectal cancer, laminin 521 (laminin-11), regorafenib, 5-fluorouracil, HT29, ITGB1, LAMA5, YAP, SFN, 14-3-3σ The study was funded by the Russian Science Foundation (Project 17-14-01338).

Low-intensity ultrasound to induce proliferation and collagen Ι expression of adipose-derived mesenchymal stem cells and fibroblast cells in co-culture

Measurement ◽  
2021 ◽  
Vol 167 ◽  
pp. 108280
Author(s):  
Zeinab Hormozi-Moghaddam ◽  
Manijhe Mokhtari-Dizaji ◽  
Mohammad-Ali Nilforoshzadeh ◽  
Mohsen Bakhshandeh
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Fibroblast Cells ◽  
Low Intensity ◽  
Low Intensity Ultrasound

EXPERIMENTAL COMPARISON OF MCF7 AND MCF10A RESPONSE TO LOW INTENSITY ULTRASOUND

2019 ◽  
Vol 19 (06) ◽  
pp. 1950057
Author(s):  
MARIANTONIETTA IVONE ◽  
LUCIANO LAMBERTI ◽  
CARMINE PAPPALETTERE ◽  
MARIANO FRANCESCO CARATOZZOLO ◽  
APOLLONIA TULLO
Keyword(s):  
Cell Stiffness ◽  
Experimental Comparison ◽  
Breast Adenocarcinoma ◽  
Mcf7 Cells ◽  
Low Intensity ◽  
Cell Mortality ◽  
The Us ◽  
Fixed Power ◽  
Breast Cells ◽  
Low Intensity Ultrasound

The low-intensity ultrasound effects on MCF7 (human breast adenocarcinoma) and MCF10A (healthy breast cells) have been investigated at different sonication protocol to probe the effectiveness and the selectivity of the ultrasound (US) treatment and to understand the implications between cell mortality, biomechanical interactions and cell elastic modulus. Experiments performed at fixed and variable frequency demonstrated the effectiveness of some protocols in killing carcinogenic cells and the healthy cells insensitivity. Variation of elastic properties of MCF7 cells exposed to US under varying sonication conditions was examined. Sonication was carried out at fixed frequency (as it is usually done in therapy protocols), between 400[Formula: see text]kHz and 620[Formula: see text]kHz, following two protocols: (i) at fixed power output; (ii) at fixed voltage of the US generator. Evolution of cell stiffness during the US treatment was monitored via atomic force spectroscopy (AFS). It was found that cell mortality has a similar trend of variation with respect to sonication frequency regardless of the way specimens are exposed to US. Mechanical properties do not show a uniform trend with respect to frequency, but variations of Young’s modulus are more marked near the very low (400–480) kHz or very high frequencies (580–620) kHz. The observed variations may be related to mechanical interactions occurring in the cell culture, suggesting a primacy of the environment on other factors.

Enhancement of Fracture Healing by Low Intensity Ultrasound

1998 ◽  
Vol 355S ◽  
pp. S216-S229 ◽  
Author(s):  
Michael Hadjiargyrou ◽  
Kenneth McLeod ◽  
John P. Ryaby ◽  
Clinton Rubin
Keyword(s):  
Fracture Healing ◽  
Low Intensity ◽  
Low Intensity Ultrasound

scholarly journals Enhancement of Cardiomyogenesis in Murine Stem Cells by Low-Intensity Ultrasound

2017 ◽  
Vol 36 (8) ◽  
pp. 1693-1706
Author(s):  
Ailing Teo ◽  
Amir Morshedi ◽  
Jen-Chieh Wang ◽  
Yufeng Zhou ◽  
Mayasari Lim
Keyword(s):  
Stem Cells ◽  
Low Intensity ◽  
Low Intensity Ultrasound

scholarly journals Modification of osteoarthritis in the guinea pig with pulsed low-intensity ultrasound treatment

2010 ◽  
Vol 18 (5) ◽  
pp. 724-733 ◽  
Author(s):  
I. Gurkan ◽  
A. Ranganathan ◽  
X. Yang ◽  
W.E. Horton ◽  
M. Todman ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Ultrasound Treatment ◽  
Low Intensity ◽  
Low Intensity Ultrasound
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