scholarly journals Detection of Salivary Tryptase Levels in Children following Oral Food Challenges

2021 ◽  
pp. 1-4
Author(s):  
Wouter W. de Weger ◽  
Vibeke M. Bruinenberg ◽  
Evelien M. van der Lek ◽  
Jeroen H. Gerrits ◽  
Lidy van Lente ◽  
...  
Keyword(s):  
Food Allergy ◽  
Limit Of Detection ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Potential Association ◽  
The Mean ◽  
Food Challenges ◽  
Assay Precision ◽  
Objective Marker ◽  
Time Point

<b><i>Background:</i></b> Oral food challenge (OFC) is commonly used to diagnose food allergy. This test is time and resource intensive, and conclusions are not always unequivocal as this relies on the interpretation of symptoms. Therefore, an objective marker would improve the accuracy of the diagnostic workup of food allergy. <b><i>Objectives:</i></b> The aim of this study was to investigate whether tryptase can be detected in saliva of children following OFC. <b><i>Method:</i></b> Children from 3 to 18 years of age were eligible for inclusion if an OFC for peanut or tree nut had been recommended. Saliva samples were collected prior to the first dose and 5, 10, and 15 min following the last administered dose during OFC. Assay precision, spike-and-recovery, and assessment of lower limit of detection of the tryptase immunoassay were examined before analysis of tryptase in saliva was performed. <b><i>Results:</i></b> A total of 30 children were included (median age 8 years, 63.3% male, 53.3% positive OFC outcome). Tryptase was detected in saliva samples. The mean of the change in baseline tryptase value to each saliva collecting time point was significantly different in patients with a positive OFC outcome compared to a negative outcome (<i>p</i> &#x3c; 0.01). <b><i>Conclusions:</i></b> This study showed that tryptase can be detected in saliva of children following OFC. Increased levels of tryptase compared to baseline were found if the OFC outcome was positive, suggesting that measuring tryptase in saliva may be useful in the diagnosis of food allergy. Further research is needed to evaluate the potential association between tryptase levels and symptoms.

scholarly journals Oral food challenges

2020 ◽  
Vol 2 (1) ◽  
pp. 31-34
Author(s):  
Amal H. Assa’ad
Keyword(s):  
Food Allergy ◽  
Peanut Allergy ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Allergic Reactions ◽  
Double Blind ◽  
Trained Personnel ◽  
Open Food Challenge ◽  
Food Challenges ◽  
Shed Light

Oral food challenge (OFC) is a procedure that is conducted most commonly by allergist/immunologists in their office or in food allergy centers to confirm a food allergy or to confirm tolerance to the food. The procedure as conducted in clinical practice is mostly open food challenge and, in research, a double-blind, placebo controlled food challenge. OFC has associated risks that can be minimized by having the challenges conducted by trained personnel who are prepared to treat allergic reactions and who have rescue medications available. However, OFCs have tremendous benefits to the patients and their families, including the potential to determine that a food is no longer an allergen and can be introduced into the diet. Even OFCs that result in clinical reactions have the benefit of confirming the food allergy and demonstrating the therapeutic effect of the rescue medications. The study of the outcomes of OFC has shed light on food allergy reactions and characteristics of the patients with food allergy as well as on the value of other diagnostic tests compared with OFC. OFCs have helped establish food allergy thresholds, confirm that subjects enrolled in research studies have the allergy, and demonstrate the response to the therapies tested in terms of ameliorating the allergic response or raising the reaction threshold. OFCs have also been used to promote the recent guidelines for the prevention of peanut allergy by identifying the infants at risk for peanut allergy but who are not allergic yet.

scholarly journals Food allergy and anaphylaxis – 2054. Easy-to-use severity grading system for treatment of symptoms induced by oral food challenge

2013 ◽  
Vol 6 ◽  
pp. P137 ◽  
Author(s):  
Noriyuki Yanagida ◽  
Yuu Okada ◽  
Hasegawa Yukiko ◽  
Taro Miura ◽  
Ishida Wako ◽  
...  
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Grading System ◽  
Severity Grading

scholarly journals Oral Food Challenge and Food Allergy Quality of Life in Caregivers of Children with Food Allergy

2015 ◽  
Vol 3 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Timothy J. Franxman ◽  
Laura Howe ◽  
Esther Teich ◽  
Matthew J. Greenhawt
Keyword(s):  
Quality Of Life ◽  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge

scholarly journals Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children

2013 ◽  
Vol 6 ◽  
pp. 14 ◽  
Author(s):  
Antonella Cianferoni ◽  
Karishma Khullar ◽  
Rushani Saltzman ◽  
Joel Fiedler ◽  
Jackie P Garrett ◽  
...  
Keyword(s):  
Food Challenge ◽  
Oral Food Challenge ◽  
Food Challenges ◽  
Fatal Anaphylaxis

Caregiver perceptions of when to offer an oral food challenge for children with food allergy

2019 ◽  
Vol 122 (6) ◽  
pp. 660-661
Author(s):  
Monica T. Kraft ◽  
Rebecca Scherzer ◽  
Elizabeth A. Erwin ◽  
Irene Mikhail
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge

Oral food challenges in clinical practice: a missing element of food allergy diagnosis in Russia

2021 ◽  
Vol 17 (4) ◽  
pp. 19-29
Author(s):  
Daria M. Levina ◽  
Ilya A. Korsunskiy ◽  
Daniel B. Munblit
Keyword(s):  
Food Allergy ◽  
Russian Federation ◽  
Food Challenge ◽  
Clinical History ◽  
Allergy Diagnosis ◽  
Laboratory Test Results ◽  
The World ◽  
Life Threatening ◽  
Food Challenges ◽  
Food Allergy Diagnosis

Food allergy is one of the most prevalent allergic conditions, causing reduction in patient quality of life. It is linked with high levels of anxiety due to potential life-threatening reactions, and high economic burden for a healthcare system. Food allergy affects approximately 5 to 10% of children around the world. In Russian Federation the diagnosis of food allergy is primarily based on clinical history, laboratory test results, examination and elimination of suspected food. Meanwhile oral food challenge (OFC) is considered a gold standard of food allergy diagnosis by most of professional bodies nationally and internationally. OFC is a diagnostic procedure involving administration of a causative allergen in gradually increasing amount under a close medical supervision. The method is safe, highly specific and sensitive and is widely used around the world for more than 45 years. The main goals of OFC include food allergy diagnosis and presence of tolerance evaluation, which may result in diet expansion. OFC may also help establishing both, reaction severity and dose needed to elicit reaction, which may further assist with alleviation of patients anxiety. In this paper we discuss existing approaches to the diagnosis of food allergy in Russian Federation and review available recommendations on OFC outlined in international guidelines.

Oral Food Challenge: Experience in a Brazilian Food Allergy Outpatient Terciary Service

2013 ◽  
Vol 131 (2) ◽  
pp. AB83
Author(s):  
Camila Pereira ◽  
Leila Borges ◽  
Renata R. Cocco ◽  
Lucila Camargo ◽  
Marcia Mallozi ◽  
...  
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge
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