Therapeutic Impact and Management of Persistent Head and Neck Atopic Dermatitis in Dupilumab-Treated Patients

Dermatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Andrea Chiricozzi ◽  
Niccolò Gori ◽  
Lucia Di Nardo ◽  
Flaminia Antonelli ◽  
Cristiano Caruso ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Head And Neck ◽  
Dermatology Life Quality Index ◽  
Negative Impact ◽  
Demographic Data ◽  
Life Quality ◽  
Severity Index ◽  
Negative Factor ◽  
Lower Likelihood ◽  
Head Neck

<b><i>Background:</i></b> Localization of atopic dermatitis (AD) in exposed areas such as the hands, head, and neck has been considered as a negative factor impacting on dupilumab response, although a comparison of exposed versus unexposed areas is not currently available. <b><i>Objectives:</i></b> The aim of this study is to evaluate the clinical response to dupilumab depending on the presence or persistency of AD skin manifestations in specific body areas. <b><i>Methods:</i></b> The study retrospectively collected clinical and demographic data of adult patients affected by moderate to severe AD. Based on the anatomical sites involved, 5 subcohorts of patients were identified. <b><i>Results:</i></b> A total of 41 patients were included in the study. Disease amelioration was detected during the study period, although baseline head/neck and hand localization was associated with a significantly lower likelihood of achieving an Eczema Area Severity Index (EASI) ≤1. In addition, patients with head/neck persistency showed a significantly lower response when compared to patients without persistency of head/neck AD in terms of both mean EASI and Dermatology Life Quality Index (DLQI) reduction. <b><i>Conclusion:</i></b> AD localization in exposed areas at the baseline and AD persistency at the head/neck may have a negative impact on certain treatment response parameters to dupilumab therapy.

Children’s dermatology life quality index and family dermatology life quality index as criteria for the efficiency of physiorehabilitation of children with atopic dermatitis

2020 ◽  
pp. 43-49
Author(s):  
T. V. Koroleva ◽  
I. I. Ivanova ◽  
E. V. Filatova
Keyword(s):  
Atopic Dermatitis ◽  
Dermatology Life Quality Index ◽  
Quality Index ◽  
Life Quality ◽  
Polarized Light ◽  
Social Maladjustment ◽  
Life Quality Index ◽  
Laser Blood Irradiation ◽  
Intensity Laser

Social maladjustment of children with atopic dermatitis, an increase in the number of cases of disability in pediatric practice, violation of intra-familial relations, rise in the level of anxiety of parents, in particular, of mothers, are closely associated with the formation of protracted recurrent forms. Educational programs for parents, traditional conservative treatment and hydrotherapy in combination with polychromatic polarized light and low-intensity laser blood irradiation significantly improve the quality of life of patients and their families, according to the corresponding indices.

scholarly journals PGA×BSA: A Measure of Psoriasis Severity Tested in Patients with Active Psoriatic Arthritis and Treated with Certolizumab Pegol

2018 ◽  
Vol 45 (7) ◽  
pp. 922-928 ◽  
Author(s):  
Jessica A. Walsh ◽  
Terri Arledge ◽  
Tommi Nurminen ◽  
Luke Peterson ◽  
Jeffrey Stark
Keyword(s):  
Psoriatic Arthritis ◽  
Dermatology Life Quality Index ◽  
Certolizumab Pegol ◽  
Life Quality ◽  
Severity Index ◽  
Strong Correlations ◽  
Double Blind ◽  
Percentage Improvement ◽  
High Concordance ◽  
Psoriasis Severity

Objective.The product of physician’s global assessment and body surface area (PGA×BSA) to assess psoriasis severity has previously been investigated in patients with psoriasis, with the aim of assessing PGA×BSA as an alternative to the time-consuming Psoriasis Area and Severity Index (PASI). Here, we investigate PGA×BSA as an alternative to PASI in patients with psoriatic arthritis (PsA).Methods.Analyses used data from the double-blind, placebo-controlled, RAPID-PsA trial (NCT01087788) that investigated the efficacy of certolizumab pegol (CZP) in patients with PsA. Outcomes assessed whether the PGA×BSA and PASI results were comparable, and whether these outcomes correlated with one another or with the Dermatology Life Quality Index (DLQI).Results.For CZP-treated patients, both PGA×BSA and PASI demonstrated similar sensitivities to treatment between baseline and Week 24, with mean improvements of 77.4% and 69.0%, respectively. Similar improvements were also seen with placebo (PGA×BSA: 3.2%, PASI: 6.1%). Achievement of 75% response criterion in PGA×BSA and PASI was attained by similar proportions of patients with CZP (PGA×BSA75: 59.0%, PASI75: 61.4%) and placebo (PGA × BSA75: 15.1%, PASI75: 15.1%). Cross tabulations showed high concordance between achievement of response outcomes in PGA×BSA and PASI (79.6–95.2%). Spearman correlations revealed strong correlations between PGA×BSA and PASI at baseline (r = 0.78; n = 225) and percentage improvement to Week 24 (r = 0.85; n = 186). Both outcomes were only moderately correlated with DLQI (r = 0.41–0.50; n = 179–249).Conclusion.PGA×BSA is sensitive to changes in skin manifestations in patients with PsA treated with CZP. Further, PGA×BSA correlates strongly with PASI, and achievement of 75% improvement was similar for PGA×BSA and PASI.

scholarly journals 245 Validation and interpretation of short form 12 and comparison with dermatology life quality index in adult atopic dermatitis

2019 ◽  
Vol 139 (5) ◽  
pp. S42
Author(s):  
J. Silverberg ◽  
J.M. Gelfand ◽  
D.J. Margolis ◽  
M. Boguniewicz ◽  
L. Fonacier ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Dermatology Life Quality Index ◽  
Quality Index ◽  
Short Form ◽  
Life Quality ◽  
Life Quality Index

Epidemiology and Management of Pediatric Head and Neck Burns: An Institutional Review

2020 ◽  
pp. 000313482095282
Author(s):  
Tyler K. Merceron ◽  
Rachael Y. Williams ◽  
Walter L. Ingram ◽  
Shelly Abramowicz
Keyword(s):  
Head And Neck ◽  
Average Length ◽  
Demographic Data ◽  
Total Body Surface Area ◽  
Acute Setting ◽  
Average Length Of Stay ◽  
Institutional Review ◽  
Total Body ◽  
Head Neck

Background Pediatric head and neck burns (HNBs) require special attention due to the potential for long-term disfigurement, functional impairment, and psychosocial stigma. Methods We performed a retrospective review of patients <18 years old admitted to Grady Memorial Hospital with a diagnosis of HNB from 2009-2017. Demographic data, burn characteristics, management, and hospital course were analyzed. Results Of the 272 patients included, 65.4% were male with a mean age of 63.2 months. Burn mechanism was primarily secondary to scalding liquids (70.2%) or flames (23.9%). The average total body surface area involved was 10.3%, and 3.0% for the head/neck. Average length of stay was 5.2 days and overall mortality was 1.1%. Twenty-five patients (9.2%) required surgery in the acute setting, and 5 (1.8%) required secondary surgery for hypertrophic scarring or contracture. Discussion Pediatric HNBs occur most commonly in males <6 years old secondary to scalding liquids or open flames. Most patients can be managed nonoperatively without long-term sequelae.

The evaluation of the effectiveness of structural resonance therapy in the patients with lupus erythematosus and comorbid pathology of the gastrointestinal tract

2016 ◽  
Vol 15 (6) ◽  
pp. 305-308
Author(s):  
Roman Nikolaevich Levshin ◽  
K. V Kotenko ◽  
L. S Kruglova ◽  
N. B Korchazhkina
Keyword(s):  
Gastrointestinal Tract ◽  
Lupus Erythematosus ◽  
Dermatology Life Quality Index ◽  
Life Quality ◽  
Severity Index ◽  
Combined Approach ◽  
General Health Status ◽  
Combined Application ◽  
Medicinal Treatment

The authors report the results obtained during the combined application of various regimens of structural resonance therapy (SRT) for the treatment of 40 patients presenting with lupus erythematosus (LE) and comorbid pathology of the gastrointestinal tract. The use of this approach in the combination with the standard medicinal treatment made it possible to achieve clinical remission of the disease and to significantly improve the skin process in 100% of the patients as appears from the data on dynamics of the severity index of the cutaneous process. Simultaneously, the general health status of the patients was considerably improved. It is concluded that the proposed combined approach markedly increases the patients’ quality of life being responsible for a 87% reduction of the quality of the dermatology life quality index which allows to recommend this method for the wide application in the clinical practice for the management of the patients with the widespread forms of lupus erythematosus and comorbid pathology of the gastrointestinal tract.

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