A Longitudinal Cohort Study of Precocious Puberty and Autism Spectrum Disorder

2021 ◽  
Author(s):  
David A. Geier ◽  
Mark R. Geier
Keyword(s):  
Autism Spectrum Disorder ◽  
Cohort Study ◽  
Precocious Puberty ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study

2019 ◽  
Vol 49 (6) ◽  
pp. 2337-2347 ◽  
Author(s):  
Antonio Gennaro Nicotera ◽  
Randi Jenssen Hagerman ◽  
Maria Vincenza Catania ◽  
Serafino Buono ◽  
Santo Di Nuovo ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Cohort Study ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Eeg Abnormalities

scholarly journals The bidirectional association between sleep problems and autism spectrum disorder: a population-based cohort study

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Maria E. Verhoeff ◽  
Laura M. E. Blanken ◽  
Desana Kocevska ◽  
Viara R. Mileva-Seitz ◽  
Vincent W. V. Jaddoe ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Cohort Study ◽  
Sleep Problems ◽  
Population Based ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Bidirectional Association

Is Neonatal Hyperbilirubinemia Exposure Associated with a Risk of Autism Spectrum Disorder? A Nationwide Cohort Study

2020 ◽  
Author(s):  
Tung-Wei Hung ◽  
Jeng-Dau Tsai ◽  
Hui-Hsien Pan ◽  
Hsuan-Ju Chen ◽  
Pen-Fen Liao ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Cohort Study ◽  
Dose Response ◽  
Autism Spectrum ◽  
Neonatal Hyperbilirubinemia ◽  
Spectrum Disorder ◽  
Research Database ◽  
Response Effect ◽  
Increased Risk ◽  
Dose Response Effect

Abstract Objective This study aimed to determine whether neonatal hyperbilirubinemia is associated with a risk of autism spectrum disorder (ASD) using a large population-based cohort. Study Design This retrospective cohort study used data from the children's database (2000–2012) of the National Health Insurance Research Database (1996–2012) in Taiwan. We included neonates who were born between 2000 and 2004 and aged <1 month diagnosed with and without hyperbilirubinemia. The primary outcome was physician-diagnosed ASD. At the end of 2012, multivariate Cox's regression analysis was used to estimate hazard ratios (HRs). Results A total of 67,017 neonates were included. The neonates with hyperbilirubinemia were associated with 1.28-fold increased risk of ASD (HR = 1.28, 95% confidence interval [CI]: 1.05–1.57) compared with those without hyperbilirubinemia. In subanalysis to determine how phototherapy and exchange transfusion treatment for hyperbilirubinemia were associated with ASD showed no association between treatment and ASD, suggesting the lack of a dose-response effect of hyperbilirubinemia on the risk of ASD. Boys had a nearly six-fold higher risk of ASD than girls (HR = 5.89, 95% CI: 4.41–7.86). Additionally, neonates born with preterm birth and low birth weight were associated with a risk of ASD (HR = 1.46, 95% CI: 1.00–2.13). Conclusion We did not observe a dose-response effect of hyperbilirubinemia on ASD, but neonatal hyperbilirubinemia may be an independent risk factor for ASD if there is a residual confounding by other perinatal complications. Therefore, this study does not support a causal link between neonatal hyperbilirubinemia exposure and the risk of ASD.

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