Characteristics of late-onset amyotrophic lateral sclerosis in a Chinese cohort

2021 ◽  
Author(s):  
Qionghua Sun ◽  
Yunyun Huo ◽  
Jiongming Bai ◽  
Haoran Wang ◽  
Fang Cui ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Late Onset ◽  
Chinese Cohort ◽  
Lateral Sclerosis

scholarly journals Epidemiology and factors predicting survival of amyotrophic lateral sclerosis in a large Chinese cohort

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ming Gao ◽  
Na Liu ◽  
Xue-Mei Li ◽  
Liu-Wen Chao ◽  
Hong-Qi Lin ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Chinese Cohort ◽  
Lateral Sclerosis

Very late-onset amyotrophic lateral sclerosis in a Portuguese cohort

2018 ◽  
Vol 19 (7-8) ◽  
pp. 619-622
Author(s):  
Miguel Oliveira Santos ◽  
Marta Gromicho ◽  
Susana Pinto ◽  
Mamede de Carvalho
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Late Onset ◽  
Lateral Sclerosis

Carpal Tunnel Syndrome in Amyotrophic Lateral Sclerosis and Late Onset Cerebellar Ataxia

1996 ◽  
Vol 21 (4) ◽  
pp. 553-558 ◽  
Author(s):  
M. MONDELLI ◽  
P. DELLA PORTA ◽  
A. ZALAFFI ◽  
A. ROSSI
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Carpal Tunnel Syndrome ◽  
Cerebellar Ataxia ◽  
Carpal Tunnel ◽  
Late Onset ◽  
Axonal Neuropathy ◽  
Electrophysiological Findings ◽  
Tunnel Syndrome ◽  
Lateral Sclerosis

We report on clinical and electrophysiological findings and management in nine patients who developed carpal tunnel syndrome during the course of amyotrophic lateral sclerosis and late onset cerebellar ataxia, two neurodegenerative diseases. The patients were treated with surgical decompression (five cases) and local steroid injections (four cases). Only one showed lasting relief of symptoms and significantly improved distal conduction in the median nerve at follow-up after 2 to 3 months. The symptoms and conduction data remained unchanged in three patients who could be followed for more than 1 year. We think that axonal neuropathy plays an important role in the development of carpal tunnel syndrome in these patients and accounts for the failure of the standard treatments.

An association study between SCFD1 rs10139154 variant and amyotrophic lateral sclerosis in a Chinese cohort

2017 ◽  
Vol 19 (5-6) ◽  
pp. 413-418 ◽  
Author(s):  
Yongping Chen ◽  
Qingqing Zhou ◽  
Xiaojing Gu ◽  
Qianqian Wei ◽  
Bei Cao ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Association Study ◽  
Chinese Cohort ◽  
Lateral Sclerosis

scholarly journals Minor Allele Frequencies and Molecular Pathways Differences for SNPs Associated with Amyotrophic Lateral Sclerosis in Subjects Participating in the UKBB and 1000 Genomes Project

2021 ◽  
Vol 10 (15) ◽  
pp. 3394
Author(s):  
Salvatore D’Antona ◽  
Gloria Bertoli ◽  
Isabella Castiglioni ◽  
Claudia Cava
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
United Kingdom ◽  
Late Onset ◽  
Minor Allele ◽  
Molecular Pathways ◽  
1000 Genomes Project ◽  
1000 Genomes ◽  
The United Kingdom ◽  
Iberian Population ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a complex disease with a late onset and is characterized by the progressive loss of muscular and respiratory functions. Although recent studies have partially elucidated ALS’s mechanisms, many questions remain such as what the most important molecular pathways involved in ALS are and why there is such a large difference in ALS onset among different populations. In this study, we addressed this issue with a bioinformatics approach, using the United Kingdom Biobank (UKBB) and the European 1000 Genomes Project (1KG) in order to analyze the most ALS-representative single nucleotide polymorphisms (SNPs) that differ for minor allele frequency (MAF) between the United Kingdom population and some European populations including Finnish in Finland, Iberian population in Spain, and Tuscans in Italy. We found 84 SNPs associated with 46 genes that are involved in different pathways including: “Ca2+ activated K+ channels”, “cGMP effects”, ”Nitric oxide stimulates guanylate cyclase”, “Proton/oligopeptide cotransporters”, and “Signaling by MAPK mutants”. In addition, we revealed that 83% of the 84 SNPs can alter transcription factor-motives binding sites of 224 genes implicated in “Regulation of beta-cell development”, “Transcription-al regulation by RUNX3”, “Transcriptional regulation of pluripotent stem cells”, and “FOXO-mediated transcription of cell death genes”. In conclusion, the genes and pathways analyzed could explain the cause of the difference of ALS onset.

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