Hyperbaric Oxygen Therapy Is Beneficial for the Improvement of Clinical Symptoms of Cerebral Palsy: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-14
Author(s):  
Yingqian Zhang ◽  
Jing Wu ◽  
Nong Xiao ◽  
Bo Li
Keyword(s):  
Systematic Review ◽  
Cerebral Palsy ◽  
Motor Function ◽  
Hyperbaric Oxygen ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Control Group ◽  
Gross Motor ◽  
Gross Motor Function

<b><i>Introduction:</i></b> Hyperbaric oxygen (HBO) has been used for the treatment of cerebral palsy for more than 20 years, but its efficacy and safety are still controversial. In this systematic review and meta-analysis, we evaluated the currently promulgated data related to the efficacy of HBO for patients with cerebral palsy. <b><i>Methods:</i></b> We searched the PubMed/Medline, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases (from their inception to April 2020) for randomized controlled trials published in English or Chinese. Two researchers used the Cochrane Collaboration tool for data extraction and an independent quality assessment. The extracted data were analyzed by Review Manager 5.3 software. <b><i>Results:</i></b> A total of 25 studies consistent with the inclusion criteria were included, with a total of 2,146 people, which included 1,185 participants in the HBO group and 961 in the control group. This meta-analysis showed that when compared with the controls, HBO therapy can improve the gross motor functions evaluated by the Gross Motor Function Measure (<i>n</i> = 696, SMD 0.29, 95% CI [0.07–0.51], Z = 2.62, <i>p</i> = 0.009) and Gross Motor Function Classification System (<i>n</i> = 248, MD –0.40, 95% CI [–0.52 to –0.27], Z = 6.28, <i>p</i> &#x3c; 0.00001), global developmental level evaluated by Gesell (<i>n</i> = 560, RR 1.30, 95% CI [1.19–1.42], Z = 6.03, <i>p</i> &#x3c; 0.00001) and developmental quotient (<i>n</i> = 374, MD 8.25, 95% CI [6.48–10.01], Z = 9.15, <i>p</i> &#x3c; 0.00001) and language expression (<i>n</i> = 270, MD 4.34, 95% CI [2.30–6.38], Z = 4.17, <i>p</i> &#x3c; 0.00001) and comprehension (<i>n</i> = 270, MD 4.87, 95% CI [2.87–6.88], Z = 4.76, <i>p</i> &#x3c; 0.00001). HBO therapy only caused mild ear pain. However, the quality of the data for all outcomes evaluated by the Grading of Recommendations Assessment, Development, and Evaluation analysis was very low. <b><i>Conclusions:</i></b> HBO therapy may produce a much more efficient clinical experiment result than the control group with cerebral palsy patients, and HBO therapy is well tolerated and relatively safe for the included participants.

scholarly journals The Effectiveness of Hippotherapy to Recover Gross Motor Function in Children with Cerebral Palsy: A Systematic Review and Meta-Analysis

Children ◽  
2020 ◽  
Vol 7 (9) ◽  
pp. 106
Author(s):  
Laura Guindos-Sanchez ◽  
David Lucena-Anton ◽  
Jose Moral-Munoz ◽  
Alejandro Salazar ◽  
Ines Carmona-Barrientos
Keyword(s):  
Systematic Review ◽  
Cerebral Palsy ◽  
Motor Function ◽  
Meta Analysis ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Gross Motor Function Measure ◽  
Function Measure

Cerebral palsy (CP) is a permanent disorder of the posture and movement, which can result in impairments of gross motor function, among others. Hippotherapy (HPT) is an emerging intervention to promote motor recovery in patients with neurological disorders, providing a smooth, precise, rhythmic, and repetitive pattern of movement to the patient. The main objective of this systematic review and meta-analysis of randomized controlled clinical trials was to analyze the effectiveness of HPT interventions on gross motor function in subjects with CP. The following databases were searched in May 2019: PubMed, Scopus, Embase, and Web of Science. The methodological quality of the randomized controlled trials was assessed using the Physiotherapy Evidence Database (PEDro) scale. A total of 10 studies were analyzed in this review, involving 452 participants. Favorable effects were obtained on the gross motor function (Gross Motor Function Measure-66, standardized mean difference (SMD) = 0.81, 95% confidence interval (CI) = 0.47–1.15, Gross Motor Function Measure-88 dimension A SMD = 0.64, 95% CI = 0.30–0.97, dimension B SMD = 0.42, 95% CI = 0.09–0.75, and dimension E SMD = 0.40, 95% CI = 0.06–0.73). The results obtained in the present review show the potential benefit of HPT intervention in improving gross motor function in children with CP.

scholarly journals Motor learning-based activities may improve functional ability in adults with severe cerebral palsy: A controlled pilot study

2021 ◽  
pp. 1-11
Author(s):  
Helle Hüche Larsen ◽  
Rasmus Feld Frisk ◽  
Maria Willerslev-Olsen ◽  
Jens Bo Nielsen
Keyword(s):  
Cerebral Palsy ◽  
Motor Learning ◽  
Motor Function ◽  
Functional Ability ◽  
Active Group ◽  
Control Group ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Learning Principles

BACKGROUND: Cerebral palsy (CP) is a neurodevelopmental disturbance characterized by impaired control of movement. Function often decreases and 15% of adults are classified as severely affected (Gross Motor Function Classification Scale III-V). Little is known about interventions that aim to improve functional abilities in this population. OBJECTIVE: To evaluate a 12-week intervention based on motor learning principles on functional ability in adults with severe CP. METHODS: 16 adults (36±10 years, GMFCS III-V) were enrolled and divided into an intervention group (Active group) and a standard care group (Control group). Primary outcome measure was Gross Motor Function Measure (GMFM-88). Secondary measures were neurological status. The Active group were measured at baseline, after the intervention and at one-month follow-up. The Control group were measured at baseline and after one month. RESULTS: Analysis showed statistically significant improvement in GMFM-88 for the Active group from baseline to post assessment compared with the Control group (group difference: 5 points, SE 14.5, p = 0.008, CI: 1.2 to 8.7). Improvements were maintained at follow-up. Results from the neurological screening showed no clear tendencies. CONCLUSIONS: The study provides support that activities based on motor learning principles may improve gross motor function in adults with severe CP.

A DYNAMIC SEATING SYSTEM FOR CHILDREN WITH CEREBRAL PALSY

2009 ◽  
Vol 12 (01) ◽  
pp. 21-30 ◽  
Author(s):  
Michael E. Hahn ◽  
Sheri L. Simkins ◽  
Jacob K. Gardner ◽  
Gaurav Kaushik
Keyword(s):  
Cerebral Palsy ◽  
Range Of Motion ◽  
Motor Function ◽  
Control Group ◽  
Significant Group ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Muscle Spasticity ◽  
Children With Cerebral Palsy ◽  
Dynamic Seating

The study's aim was to determine the initial effects of a dynamic seating system as a therapeutic intervention in children with cerebral palsy. A two-factor, repeated-measures design was used. Twelve children with neuromuscular dysfunction (mean age 6.0, SD 2.7 years) were included in the study, randomly assigned to an experimental or a control group. At study initiation the experimental group received a wheelchair with dynamic seating components that allows limited range of motion in the hip and knee, and the control group received a static setting wheelchair. Participants were evaluated for range of motion, muscle spasticity (Modified Ashworth Scale), motor function (Gross Motor Function Measure), and level of disability (Pediatric Evaluation of Disability Inventory) at study initiation, 3-months, and 6-months post intervention. Both groups improved in motor function over time, particularly in the categories of Sitting and Crawl/Kneel. Measures of disability improved in both groups for the categories of self-care, mobility, and social function. A larger, more homogeneous sample would likely show significant group differences in measures of muscle spasticity, gross motor function and disability.

scholarly journals Effect of Action Observation Training on Spasticity, Gross Motor Function, and Balance in Children with Diplegia Cerebral Palsy

Children ◽  
2020 ◽  
Vol 7 (6) ◽  
pp. 64
Author(s):  
Young-a Jeong ◽  
Byoung-Hee Lee
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Action Observation ◽  
Training Group ◽  
Control Group ◽  
Spastic Diplegia ◽  
Post Intervention ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Observation Training

This study evaluated the effect of action observation training on spasticity, gross motor function, and balance in children with spastic diplegia cerebral palsy. Eighteen children with cerebral palsy participated in this study. The participants were randomized into the action observation training group (n = 9) and a control group (n = 9). The action observation training group repeatedly practiced the action with their motor skills, while the control group practiced conventional physical therapy. Both groups received 30 min sessions, 3 days a week, for 6 weeks. To confirm the effects of intervention, the spasticity, gross motor function measurement (GMFM), and pediatric reaching test (PRT) were evaluated. The results showed that in the plantar flexor contracture test of both sides, the Modified Tardieu Scale (MTS) of the right side of knee joints, GMFM-B, C, and D were significantly increased between pre- and post-intervention within both groups (p < 0.05). PRT was significantly increased between pre- and post-intervention within the both groups (p < 0.05), and there was a significant difference between the two groups (p < 0.05). These results suggest that action observation training is both feasible and beneficial for improving spasticity, gross motor function, and balance in children with spastic diplegia cerebral palsy.

The effect of interactive computer play on balance and functional abilities in children with moderate cerebral palsy: a pilot randomized study

2019 ◽  
Vol 33 (4) ◽  
pp. 704-710 ◽  
Author(s):  
Tamis W Pin ◽  
Penelope B Butler
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Intervention Group ◽  
Controlled Study ◽  
Control Group ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Gross Motor Function Measure ◽  
Significant Difference ◽  
Function Measure

Objectives: To investigate the feasibility and potential efficacy of a six-week interactive computer play training on balance and gross motor function in children with moderate cerebral palsy. Design: A pilot single-blinded matched randomized controlled study. Setting: Community. Participants: In total, 18 children with moderate cerebral palsy were recruited, paired according to age and severity of cerebral palsy and randomized into intervention group or control group. Intervention: The intervention group received additional trunk control training using the interactive computer play in sitting four times per week, 20 minutes per session for six weeks. All study children continued their usual physiotherapy programme. Measurements: All study children were assessed at baseline, week 3, week 6 (completion of intervention) and week 12 using the Pediatric Reach Test, Gross Motor Function Measure–66-Item Set and 2-Minute Walk Test. Results: All intervention children completed and enjoyed the training with no reported adverse event. All children were assessed at all time points. No significant difference was found between the two groups in all assessments. In both groups of children, significant improvements were found in the Gross Motor Function Measure–66-Item Set between week 3 (intervention group: mean 53.41, SD 5.34; control group: mean 52.86, SD 8.33) and week 6 (intervention group: mean 55.00, SD 6.32; control group: mean 54.20, SD 8.35). Conclusion: The intervention protocol of a six-week interactive computer play training was feasible and safe for children with moderate cerebral palsy in special school settings. Future studies with larger sample sizes or using single-subject designs are recommended.

scholarly journals The carry-over effect of an aquatic-based intervention in children with cerebral palsy

2018 ◽  
Vol 7 ◽  
Author(s):  
Samantha J. Ballington ◽  
Rowena Naidoo
Keyword(s):  
Cerebral Palsy ◽  
Motor Function ◽  
Intervention Group ◽  
Average Score ◽  
Control Group ◽  
Function Measurement ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Carry Over ◽  
Carry Over Effect

Background: Cerebral palsy (CP) is the most common motor disability in childhood. Children with CP are more likely to have lower levels of physical activity than their peers, which has negative implications for their health. However, aquatic exercise can be used to improve levels of fitness among children with CP.Objective: To determine the carry-over effect of an aquatic-based programme (postural control and balance) on land (walking, running and jumping) in children with CP, post aquatic intervention.Method: The study used a pretest-post-test, randomised group, cross-over design. Children aged 8–12 years (n = 10) were divided into intervention (n = 5) and control (n = 5) groups. The intervention group participated in two 30-min sessions a week, while the control group continued with normal activities. Pre- and post-intervention testing was conducted using gross motor function measurement. The 10-point programme of the Halliwick Concept was used.Results: Results demonstrated that the aquatic therapy had a significant effect on gross motor function scores. The aquatic programme-based group showed increased motor function following the intervention, compared to the control group (z = -2.803, p = 0.005). Furthermore, the aquatic-based therapy improved the average score for gross motor function measurement, post-intervention.Conclusion: Together with conventional modes of therapy, aquatic-based programmes should be integrated and considered as an essential, ongoing mode of treatment for children with CP, in order to ensure long-term gross motor function improvements.

scholarly journals The efficacy of kinesiology taping for improving gross motor function in children with cerebral palsy: A systematic review

2018 ◽  
Vol 74 (1) ◽  
Author(s):  
Marianne Unger ◽  
Juan P. Carstens ◽  
Natasha Fernandes ◽  
Rulanda Pretorius ◽  
Suzelle Pronk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cerebral Palsy ◽  
Motor Function ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Children With Cerebral Palsy
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