scholarly journals The Prediction of Inadequate Colon Capsule Cleansing: A Cohort Selection Guided by CC-CLEAR

2021 ◽  
pp. 1-11
Author(s):  
Rui de Sousa Magalhães ◽  
Pedro Boal Carvalho ◽  
Bruno Rosa ◽  
Maria João Moreira ◽  
José Cotter
Keyword(s):  
Bowel Preparation ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Outcome Variable ◽  
Discriminative Power ◽  
Impaired Mobility ◽  
Colon Cleansing ◽  
Colon Capsule ◽  
Inadequate Bowel Preparation ◽  
And Performance

<b><i>Introduction:</i></b> In order to optimize the rate of adequate cleansing in colon capsule, it may be important to identify risk factors that can predict a suboptimal colon preparation. <b><i>Aim:</i></b>To define predictive factors for inadequate bowel preparation in colon capsule, according to CC-CLEAR (Colon Capsule CLEansing Assessment and Report). <b><i>Methods:</i></b> Retrospective, single center, cohort study. Patients’ demographics, data, and quality of bowel preparation, according to CC-CLEAR, were collected retrospectively. A univariate analysis tested the association between covariables and the outcome, inadequate cleansing. The statistically significant variables were included in multivariable logistic binary regression, and a receiver operating characteristic curve (ROC) assessment was performed. <b><i>Results:</i></b> We included 167 consecutive colon capsules. Sixty-eight percent (<i>n</i> = 114) of patients were female, with a mean age of 64 years. The main indication for colon capsule was previous incomplete colonoscopy, in 158 patients (94.6%). The colon capsules cleansing was graded as good or excellent in 96 patients (57.5%) and as inadequate in 71 (42.5%), according to CC-CLEAR. The variables inadequate previous colon cleansing (OR adjusted 41.72 [95% CI 12.57–138.57], <i>p</i> value &#x3c; 0.001); chronic laxative (OR adjusted 4.86 [95% CI 1.08–21.79], <i>p</i> value = 0.039); antidepressant (OR adjusted 5.00 [95% CI 1.65–15.16], <i>p</i> value = 0.004), and impaired mobility (OR adjusted 5.54 [95% CI 1.17–26.31], <i>p</i> value = 0.031) were independently associated with the outcome inadequate cleansing, after adjusting for confoundment. The model presented an excellent discriminative power towards the outcome variable (AUC ROC 0.937 [CI 95% 0.899–0.975], <i>p</i> value &#x3c; 0.001). <b><i>Conclusion:</i></b> A previous inadequate colon cleansing, the use of chronic laxative and antidepressant, or impaired mobility are predictors of inadequate colon capsule cleansing, as assessed by the CC-CLEAR. These 4 predictors come together as a model enabling an accurate categorization of the patients at major risk of inadequate bowel preparation for capsule colonoscopy, with an excellent discriminative power and performance, which seems useful for the selection of patients for tailored optimization of the colon cleansing protocol.

P.02.7 A SECOND STRATEGY COLON CLEANSING FOR COLONOSCOPY AFTER AN INADEQUATE BOWEL PREPARATION

2019 ◽  
Vol 51 ◽  
pp. e150
Author(s):  
E. Dal Pont ◽  
L.G. Cavallaro ◽  
E. Galliani ◽  
P. Lecis ◽  
E. Losso ◽  
...  
Keyword(s):  
Bowel Preparation ◽  
Colon Cleansing ◽  
Inadequate Bowel Preparation

scholarly journals Factors Influencing Cecal Intubation Time during Retrograde Approach Single-Balloon Enteroscopy

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Tzu-Ming Ou ◽  
Peng-Jen Chen ◽  
Yu-Lueng Shih ◽  
Meng-Ting Wang ◽  
Hsin-Hung Huang ◽  
...  
Keyword(s):  
Bowel Preparation ◽  
Univariate Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Predisposing Factors ◽  
Intubation Time ◽  
Multivariate Logistic Regression ◽  
Cecal Intubation ◽  
Factors Influencing ◽  
Cecal Intubation Time ◽  
Inadequate Bowel Preparation

Background and Aim. The predisposing factors for prolonged cecal intubation time (CIT) during colonoscopy have been well identified. However, the factors influencing CIT during retrograde SBE have not been addressed. The aim of this study was to determine the factors influencing CIT during retrograde SBE.Methods. We investigated patients who underwent retrograde SBE at a medical center from January 2011 to March 2014. The medical charts and SBE reports were reviewed. The patients’ characteristics and procedure-associated data were recorded. These data were analyzed with univariate analysis as well as multivariate logistic regression analysis to identify the possible predisposing factors.Results. We enrolled 66 patients into this study. The median CIT was 17.4 minutes. With univariate analysis, there was no statistical difference in age, sex, BMI, or history of abdominal surgery, except for bowel preparation(P=0.021). Multivariate logistic regression analysis showed that inadequate bowel preparation (odds ratio 30.2, 95% confidence interval 4.63–196.54;P<0.001) was the independent predisposing factors for prolonged CIT during retrograde SBE.Conclusions. For experienced endoscopist, inadequate bowel preparation was the independent predisposing factor for prolonged CIT during retrograde SBE.

scholarly journals P148 ANA and Anti-dsDNA antibody enabling the prediction of inflammatory arthritis in inflammatory bowel disease

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S230-S230
Author(s):  
R de Sousa Magalhães ◽  
T Lima Capela ◽  
B Rosa ◽  
M J Moreira ◽  
J Cotter
Keyword(s):  
Inflammatory Arthritis ◽  
Biological Treatment ◽  
Univariate Analysis ◽  
Treatment Session ◽  
Multivariate Model ◽  
Outcome Variable ◽  
Extraintestinal Manifestation ◽  
Dsdna Antibody ◽  
Inflammatory Bowel ◽  
And Performance

Abstract Background Inflammatory arthritis is frequent as an extraintestinal manifestation of IBD, as well as a paradoxical reaction to biological treatment. Anti-nuclear antibody (ANA) and Anti-dsDNA antibody have been associated with inflammatory arthritis. We aim to assess the correlation between the presence of ANA and Anti-dsDNA antibody and the diagnosis of inflammatory arthritis in patients with IBD under biological treatment. Methods We present a cohort study, including IBD patients under biological treatment, presenting at least a treatment session in the first 2 months of 2020. Data was gathered from medical records, laboratorial analysis, namely ANA and Anti-dsDNA, were collected in the treatment session, and every patient posteriorly answered telephonically validated questionnaires to assess the presence of inflammatory arthritis, the outcome variable. A univariate analysis followed by a multivariate logistic regression, including statistically significant variables, tested the correlation towards inflammatory arthritis. A ROC curve tested the performance of the final model. Results We included 122 patients, 64 (52.5%) were women, and the mean age was 39 years old. Eighty-six (70.5%) patients presented Crohn’s Disease and 36 (29.5%) Ulcerative Colitis. A hundred (82%) patients were under Infliximab, 21 under Vedolizumab (17.2%) and only 1(0.8%) under Adalimumab. Thirty-three patients (27%) met questionnaire criteria for inflammatory arthritis, either peripheric or axial. The variables age, ANA and ANA’s title, age at IBD diagnosis and number of symptomatic articulations involved were associated with the presence of inflammatory arthritis. The multivariate model including ANA (OR 4.149 [1.03–16.711] p=0.045); number of articulations involved (OR 2.683 [1.783–4.038] p&lt;0.001) and higher age at IBD diagnosis, accurately identified patients with diagnosis of inflammatory arthritis (ROC AUC 0.957 [0.926–0.987] p&lt;0.001). A sub-analysis correlating ANA and the presence of inflammatory arthritis after biological initiation showed a statistical tendency (OR 2.231 [0.908–5.478] p&lt;0.08). Conclusion The presence of ANA antibodies and a higher number of symptomatic articulations involved independently increased the rate of inflammatory arthritis diagnosis in up to 4 times, in a cohort of patients with IBD under biological treatment. The inclusion in a multivariate model displayed an excellent accuracy and performance towards the diagnosis of inflammatory arthritis. ANA antibodies together with validated questionaries may aid in the identification of IBD patients suffering from inflammatory arthritis.

A PREDICTIVE SCORE OF INADEQUATE BOWEL PREPARATION BASED ON A SELF-ADMINISTRED QUESTIONNAIRE

2018 ◽  
Author(s):  
A Berger ◽  
E Cesbron-Métivier ◽  
S Bertrais ◽  
A Olivier ◽  
A Becq ◽  
...  
Keyword(s):  
Bowel Preparation ◽  
Predictive Score ◽  
Inadequate Bowel Preparation

scholarly journals Risk Factors of Inadequate Bowel Preparation for Screening Colonoscopy

2021 ◽  
Vol 10 (12) ◽  
pp. 2740
Author(s):  
Efrat L. Amitay ◽  
Tobias Niedermaier ◽  
Anton Gies ◽  
Michael Hoffmeister ◽  
Hermann Brenner
Keyword(s):  
Risk Factors ◽  
Bowel Preparation ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Screening Colonoscopy ◽  
Cross Sectional ◽  
Factors Associated ◽  
Screening Practice ◽  
Abdominal Symptoms ◽  
Inadequate Bowel Preparation

The success of a colonoscopy in detecting and removing pre-cancerous and cancerous lesions depends heavily on the quality of bowel preparation. Despite efforts, 20–44% of colonoscopy participants have an inadequate bowel preparation. We aimed to assess and compare risk factors for inadequate bowel preparation and for the presence of advanced colorectal neoplasms in routine screening practice. In this cross-sectional study, among 8125 participants of screening colonoscopy in Germany with a comprehensive assessment of sociodemographic factors, lifestyle and medical history, we examined factors associated with inadequate bowel preparation and with findings of advanced neoplasms using adjusted log-binomial regression models. Among the identified risk factors assessed, three factors were identified that were significantly associated with inadequate bowel preparation: age ≥ 70 years (adjusted prevalence ratios, aPR, 1.50 95%CI 1.31–1.71), smoking (aPR 1.29 95%CI 1.11–1.50) and abdominal symptoms (aPR 1.14 95%CI 1.02–1.27). The same risk factors were also associated with the prevalence of advanced neoplasms in our study (aPR 1.72, 1.62 and 1.44, respectively). The risk factors associated with inadequate bowel preparation in this study were also associated with a higher risk for advanced neoplasms. Inadequate bowel preparation for colonoscopy might lead to missed colorectal cancer (CRC) precursors and the late diagnosis of CRC. People at high risk of advanced neoplasms are in particular need of enhanced bowel preparation.

scholarly journals Prospective Validation of Pentraxin-3 as a Novel Serum Biomarker to Predict the Risk of Prostate Cancer in Patients Scheduled for Prostate Biopsy

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1611
Author(s):  
Ugo Giovanni Falagario ◽  
Gian Maria Busetto ◽  
Giuseppe Stefano Netti ◽  
Francesca Sanguedolce ◽  
Oscar Selvaggio ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Predictive Accuracy ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Digital Rectal Examination ◽  
Multivariable Logistic Regression Analysis ◽  
Gleason Grade ◽  
Pentraxin 3 ◽  
Net Benefit ◽  
Multivariable Models

Purpose: To test and internally validate serum Pentraxin-3 (PTX3) levels as a potential PCa biomarker to predict prostate biopsy (PBx) results. Materials and Methods: Serum PSA and serum PTX3 were prospectively assessed in patients scheduled for PBx at our Institution due to increased serum PSA levels or abnormal digital rectal examination. Uni- and multivariable logistic regression analysis, area under the receiver operating characteristic curve (AUC), and decision curve analysis (DCA), were used to test the accuracy of serum PTX3 in predicting anyPCa and clinically significant PCa (csPCa) defined as Gleason Grade (GG) ≥ 2. Results: Among the 455 eligible patients, PCa was detected in 49% and csPCa in 25%. During univariate analysis, PTX3 outperformed other variables in predicting both anyPCa and csPCa. The addition of PTX3 to multivariable models based on standard clinical variables, significantly increased each model’s predictive accuracy for anyPCa (AUC from 0.73 to 0.82; p < 0.001) and csPCa (AUC from 0.79 to 0.83; p < 0.001). At DCA, PTX3, and PTX3, density showed higher net benefit than PSA and PSA density and increased the net benefit of multivariable models in deciding when to perform PBx. Conclusions: Serum PTX3 levels might be of clinical utility in predicting prostate biopsy results. Should our findings be confirmed, this novel reflex test could be used to reduce the number and burden of unnecessary prostate biopsies.

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