A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid

2021 ◽  
Author(s):  
Sung Ha Lim ◽  
Eun Jung Kim ◽  
Chung Hyuk Lee ◽  
Gi Hyun Park ◽  
Kang Min Yoo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Topical Corticosteroid ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Lipid Mixture ◽  
Chain Lengths

scholarly journals Effect of Alkyl Structure (Straight Chain/Branched Chain/Unsaturation) of C18 Fatty Acid Sodium Soap on Skin Barrier Function

2020 ◽  
Vol 10 (12) ◽  
pp. 4310
Author(s):  
Koji Kubota ◽  
Akie Kakishita ◽  
Mana Okasaka ◽  
Yuka Tokunaga ◽  
Sadaki Takata
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Barrier Function ◽  
Anionic Surfactants ◽  
Skin Barrier ◽  
Fatty Acid Soap ◽  
Skin Tissue ◽  
Acid Soap ◽  
Skin Barrier Function ◽  
Transmission Index

Anionic surfactants are commonly used as detergents and emulsifiers. However, these compounds are potent skin irritants. In this study, we evaluated the effect of the alkyl structure of anionic surfactants on the skin barrier function using the transmission index (TI) method. The TI method is used to measure the skin penetration rate of drugs. Sodium soaps of C18 fatty acids with different structures were evaluated. Sodium laurate was used as the control. In addition, microscopic observations of the skin tissue treated with different soaps and controls were performed to study the mechanism of skin permeation. Results showed that unsaturated fatty acid soaps exerted the most potent effect on the skin barrier function and saturated fatty acid soaps exerted the least effect; saturated branched fatty acid soap had an intermediate effect. This could be attributed to the differences in the melting points of different fatty acids. In addition, unlike lauric acid soap, C18 fatty acid soap did not cause morphological changes in the skin tissue. Thus, differences in the alkyl structure of fatty acids resulted in differences in the effect of fatty acid soaps on the skin barrier function. The mechanism was presumed to be an effect on intercellular lipids.

scholarly journals Diet and Skin Barrier: The Role of Dietary Interventions on Skin Barrier Function

2021 ◽  
pp. e2021132
Author(s):  
Milbrey A. Parke ◽  
Ariadna Perez-Sanchez ◽  
Dina H. Zamil ◽  
Rajani Katta
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Laboratory Animal ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Dietary Interventions ◽  
Stratum Corneum Hydration ◽  
Other Substances

Multiple research studies have examined the role of specific dietary interventions and their effects on skin barrier function. The skin barrier is one of the body's first lines of protection against environmental insults, and disruption of this natural line of defense can result in xerosis, irritation, chronic dermatitis, and other cutaneous effects. Multiple laboratory, animal, and human studies have demonstrated that certain dietary interventions have the potential to impact skin barrier function. Measurements of skin barrier function include stratum corneum hydration and transepidermal water loss. In this review, we examine this research and provide an overview of the effects of prebiotics, probiotics, fatty acids, and emerging research on other substances.

scholarly journals Lipidomics Profiling of Skin Surface Lipids in Senile Pruritus

2020 ◽  
Author(s):  
xiaolei Ma ◽  
Lulu Lu ◽  
Zheng Zhao ◽  
Mingru Cai ◽  
Na Gao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Surface ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Surface Lipid ◽  
Control Subjects ◽  
Peking University ◽  
Skin Surface Lipids

Abstract Background: Senile pruritus is common, yet its etiology remains unknown. Aging-associated skin barrier defects and skin surface lipid (SSL) alterations have been postulated to play important roles in its occurrence. In the present study, the lipidomic profiles of SSLs in elderly patients were examined to better understand the potential causes of senile pruritus. Methods: Transepidermal water loss (TEWL) was evaluated to assess the skin barrier function. The Ameliorated Kawashima Itch Scale score was used to measure the pruritus severity. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were employed to investigate SSL alterations. Results: The results showed that senile pruritus patients had higher TEWL values than control subjects (13.13±4.28 versus 6.71±2.45, p<0.01). LC-MS/MS revealed significant differences in the lipidomic profiles and identified 81 species of SSLs that differed between the two groups. Compared with control subjects, senile pruritus patients had increased levels of ceramides (Cers), diacylglycerols, fatty acids, phosphatidylcholines, phosphatidylethanolamines, phytosphingosines, sphingosines, diacylceryl-3-O-carboxyhydroxymethylcholine, diacylglyceryl trimethylhomoserine, and unsaturated free fatty acids, but decreased levels of triacylglycerol. Cer-EOS, Cer-NDS, and Cer-NS were positively correlated with TEWL value (p<0.05). Pruritus severity score was positively correlated with sphingomyelin, Cer-NP, Cer-AS, Cer-NDS, and Cer-NS, but negatively correlated with Cer-BS, Cer-EODS, Cer-EOS, and Cer-AP. Conclusions: The present study indicated that patients with senile pruritus have impaired skin barrier function and altered SSL composition. Certain SSL species identified in this study may be potential targets for future studies on the pathogenesis of senile pruritus.Trial registration: Peking University International Hospital (Number: YN2018QN04; date: January 2019).

scholarly journals Lipidomics Profiling of Skin Surface Lipids in Senile Pruritus

2020 ◽  
Author(s):  
xiaolei Ma ◽  
Lulu Lu ◽  
Zheng Zhao ◽  
Mingru Cai ◽  
Na Gao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Skin Barrier ◽  
The Elderly ◽  
Skin Surface ◽  
Skin Barrier Function ◽  
Future Studies ◽  
Severity Scores ◽  
Surface Lipids ◽  
Skin Surface Lipids

Abstract Background: Senile pruritus is common, yet its etiology remains unknown. We examined the lipidomics profiles of skin surface lipids (SSL) in the elderly to better understand potential causes for senile pruritus. Methods:Transepidermal water loss (TEWL) was used to assess skin barrier function. Ameliorated Kawashima itch scale were used to measure the pruritus score. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were used to investigate SSL alternations. Results:The results showed that the senile pruritus have higher TEWL values than controls (13.13±4.28 versus 6.71±2.45, p< 0.01). LC-MS/MS showed significant differences in lipidomics and identified 81 species of SSL that differ between two groups. Compared to controls, the levels of ceramides, diacylcerols, fatty acids, phosphatidylcholines, phosphatidylethar, phytosphingsines, sphingosines, diacylceryl-3-O-carboxyhydroxymethylcholine, diacylglyceryl trimethylhomoserine, unsaturated free fatty acids increased, whereas triacylglycerol decreased. CER-EOS, CER-NDS and CER-NS were positively correlated with TEWL values (p<0.05). Sphingomyelin, Cer-NP, Cer-AS, Cer-NDS, Cer-NS were positively correlated with pruritus severity scores, while Cer-BS, Cer-EODS, Cer-EOS, Cer-AP were negatively correlated. Conclusion:Our study indicated that the senile pruritus have impaired skin barrier function and altered SSL composition. Select SSL species identified in this study may be potential target for future studies on the pathogenesis of idiopathic senile pruritus

scholarly journals Lipidomics Profiling of Skin Surface Lipids in Senile Pruritus

2020 ◽  
Author(s):  
xiaolei Ma ◽  
Lulu Lu ◽  
Zheng Zhao ◽  
Mingru Cai ◽  
Na Gao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Surface ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Control Subjects ◽  
Surface Lipids ◽  
Peking University ◽  
Skin Surface Lipids

Abstract Background: Senile pruritus is common, yet its etiology remains unknown. Aging-associated skin barrier defects and skin surface lipids (SSL) alterations have been postulated to play important roles in its occurrence. In the present study, the lipidomic profiles of SSLs in elderly patients were examined to better understand the potential causes of senile pruritus. Methods: Transepidermal water loss (TEWL) was evaluated to assess the skin barrier function. The Ameliorated Kawashima Itch Scale score was used to measure the pruritus severity. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were employed to investigate SSL alterations. Results: The results showed that senile pruritus patients had higher TEWL values than control subjects (13.13±4.28 versus 6.71±2.45, P<0.01). LC-MS/MS revealed significant differences in the lipidomic profiles and identified 81 species of SSLs that differed between the two groups. Compared with control subjects, senile pruritus patients had increased levels of ceramides (Cers), diacylglycerols, fatty acids, phosphatidylcholines, phosphatidylethanolamines, phytosphingosines, sphingosines, diacylceryl-3-O-carboxyhydroxymethylcholine, diacylglyceryl trimethylhomoserine, and unsaturated free fatty acids, but decreased levels of triacylglycerol. Cer-EOS, Cer-NDS, and Cer-NS were positively correlated with TEWL value (P<0.05). Pruritus severity score was positively correlated with sphingomyelin, Cer-NP, Cer-AS, Cer-NDS, and Cer-NS, but negatively correlated with Cer-BS, Cer-EODS, Cer-EOS, and Cer-AP. Conclusions: The present study indicated that patients with senile pruritus have impaired skin barrier function and altered SSL composition. Certain SSL species identified in this study may be potential targets for future studies on the pathogenesis of senile pruritus.Trial registration: Peking University International Hospital (Number: YN2018QN04; date: January 2019).

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