Beyond Bone Mineral Density: The Impact of Childhood Cancer and Its Treatment on Bone Structure and Strength

2021 ◽  
pp. 1-22
Author(s):  
Melissa Fiscaletti ◽  
Nathalie Alos ◽  
Leanne M. Ward
Keyword(s):  
Bone Mineral Density ◽  
Childhood Cancer ◽  
Bone Mineral ◽  
Bone Structure ◽  
Mineral Density ◽  
The Impact

scholarly journals Doping dose of salbutamol and exercise: deleterious effect on cancellous and cortical bones in adult rats

2007 ◽  
Vol 102 (4) ◽  
pp. 1502-1509 ◽  
Author(s):  
N. Bonnet ◽  
C. L. Benhamou ◽  
H. Beaupied ◽  
N. Laroche ◽  
L. Vico ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Deleterious Effect ◽  
Treadmill Exercise ◽  
Bone Structure ◽  
Bone Architecture ◽  
Mineral Density ◽  
Adult Rats ◽  
Femoral Bone Mineral Density ◽  
The Impact

Animal studies suggest that bone remodeling is under β-adrenergic control via the sympathetic nervous system. To our knowledge, the impact of β-agonist substances, at doping doses, has not been studied in adult rats. The purpose of this study was to examine the effects of salbutamol injections with or without treadmill exercise on trabecular and cortical bone in adult rats. Adult (36 wk of age) female Wistar rats ( n = 56) were treated with salbutamol (3 mg·kg−1·day−1 sc, 5 days/wk) or vehicle (sham) with or without subsequent treadmill exercise (13 m/min, 60 min/day, 5 days/wk) for 10 wk. Tibial and femoral bone mineral density was analyzed by dual-energy X-ray absorptiometry. Metaphysic trabecular bone structure was analyzed by micro-CT at the time of the animals' death. Bone cell activities were assessed histomorphometrically. After 10 wk, the increase in bone mineral density was less in salbutamol-treated than in sham rats (+3.3% vs. +12.4%, P < 0.05), and trabecular parameters were altered and bone resorption was increased in salbutamol-treated rats compared with controls. The negative effect on bone architecture in salbutamol-treated rats persisted, even with treadmill exercise. These results confirm the deleterious effect of β2-agonists on bone mass during chronic treatment and describe its effects on bone mechanical properties in adult rats. Bone loss occurred independently of a salbutamol-induced anabolic effect on muscle mass and was equally severe in sedentary and exercising rats, despite a beneficial effect of exercise on the extrinsic and intrinsic energy to ultimate strain. These bone effects may have important consequences in athletes who use salbutamol as a doping substance.

Determinants of bone mineral density in long-term adult survivors of childhood cancer

2013 ◽  
Author(s):  
C Klap B ◽  
L te Winkel M ◽  
den Hoed M ◽  
van Waas M ◽  
J C M M Neggers S ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Childhood Cancer ◽  
Bone Mineral ◽  
Adult Survivors ◽  
Mineral Density ◽  
Survivors Of Childhood Cancer

scholarly journals A REVIEW: MECHANISTIC INSIGHTS INTO THE EFFECT OF THYROID DISORDERS ON ESTROGEN LEVEL AND BONE MINERAL DENSITY

2019 ◽  
pp. 9-17
Author(s):  
MINAKSHI JOSHI ◽  
SHRADHA BISHT ◽  
MAMTA F. SINGH
Keyword(s):  
Bone Mineral Density ◽  
Thyroid Hormone ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Disorders ◽  
Hypothyroid Patient ◽  
Mineral Density ◽  
Estrogen Level ◽  
The Impact

Thyroid hormone serves as an indispensable component for the optimum functioning of various biological systems. They curb body’s metabolism, regulates the estrogen level, regulates bone turnover, essential for skeletal development and mineralization. Within the scope of knowledge, it is intimately familiar that thyroid disorders have widespread systemic manifestations, among which in hypothyroidism, even though elevated TSH (thyroid-stimulating hormone) may reduce estrogen level which in turn stimulates osteoclasts and thus cause osteoporosis, while hyperthyroidism accelerates bone turnover. Hypothyroidism does not directly interfere with the skeletal integrity, but treatment with levothyroxine for the suppression of TSH to bring the hypothyroid patient to euthyroid state for a long haul; lead to simultaneous reduction in bone mass and in (bone mineral density) BMD. After the initial relevation of the correlation between thyroid disorders and osteoporosis in numerous studies have emphasized that both hypo and hyperthyroidism either directly or indirectly affects the bone mineral density or leads to the progression of osteoporosis. Therefore the present study is aimed and so designed to review all the possible associations between them and the impact of thyroid disorders on estrogen level and bone mineral density. The main findings of this review indicate that both excesses as well as deficiency of thyroid hormone can be potentially deleterious for bone tissue.

scholarly journals Bone mineral density predictors in long-standing type 1 and type 2 diabetes mellitus

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Stefana Catalina Bilha ◽  
Letitia Leustean ◽  
Cristina Preda ◽  
Dumitru D. Branisteanu ◽  
Laura Mihalache ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Mineral Density ◽  
Cross Sectional ◽  
The Impact

Abstract Background Despite the increased fracture risk, bone mineral density (BMD) is variable in type 1 (T1D) and type 2 (T2D) diabetes mellitus. We aimed at comparing independent BMD predictors in T1D, T2D and control subjects, respectively. Methods Cross-sectional case-control study enrolling 30 T1D, 39 T2D and 69 age, sex and body mass index (BMI) – matched controls that underwent clinical examination, dual-energy X-ray absorptiometry (BMD at the lumbar spine and femoral neck) and serum determination of HbA1c and parameters of calcium and phosphate metabolism. Results T2D patients had similar BMD compared to T1D individuals (after adjusting for age, BMI and disease duration) and to matched controls, respectively. In multiple regression analysis, diabetes duration – but not HbA1c- negatively predicted femoral neck BMD in T1D (β= -0.39, p = 0.014), while BMI was a positive predictor for lumbar spine (β = 0.46, p = 0.006) and femoral neck BMD (β = 0.44, p = 0.007) in T2D, besides gender influence. Age negatively predicted BMD in controls, but not in patients with diabetes. Conclusions Long-standing diabetes and female gender particularly increase the risk for low bone mass in T1D. An increased body weight partially hinders BMD loss in T2D. The impact of age appears to be surpassed by that of other bone regulating factors in both T1D and T2D patients.

scholarly journals Role of Dietary Intake and Serum 25(OH)D on the Effects of a Multicomponent Exercise Program on Bone Mass and Structure of Frail and Pre-Frail Older Adults

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3016
Author(s):  
Ana Moradell ◽  
David Navarrete-Villanueva ◽  
Ángel I. Fernández-García ◽  
Jorge Marín-Puyalto ◽  
Alejandro Gómez-Bruton ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Dietary Intake ◽  
Bone Mineral ◽  
Bone Structure ◽  
Quantitative Computed Tomography ◽  
Mineral Density ◽  
Frail Older Adults ◽  
Frail Elders ◽  
Tibia Length

The multicomponent training (MCT) effect on bone health in frail and pre-frail elders, which is influenced by dietary intake, is still unknown. The objective of this non-randomized intervention trial was to assess the effects of a 6-month MCT on bone structure in frail and pre-frail elders, and to analyse the influence of dietary intake and serum vitamin D (25(OH)D) in these changes. Thirty MCT (TRAIN) and sixteen controls (CON), frail and pre-frail completed the information required for this study. Peripheral quantitative computed tomography measurements were taken at 4% and 38% of the tibia length and dietary intake was registered. The 25(OH)D values were obtained from blood samples. Analyses of covariance (ANCOVA) for repeated measures showed significant decreases for CON in total bone mineral content at 38% of tibia length. One factor ANOVAs showed smaller decreases in bone mineral density and cortical thickness percentage of change in TRAIN compared to CON. Linear regression analyses were performed to study the influence of nutrients and 25(OH)D on bone changes. Alcohol showed a negative influence on fracture index changes, while polyunsaturated fatty acid and vitamin A showed a positive association with some bone variables. The 25(OH)D only affected positively the cortical bone mineral density. In conclusion, our MCT seems to slow down some of the bone detriments associated with ageing in frail and pre-frail older adults, with alcohol showing a negative effect on the bone and apparent limited effect of nutrients and serum 25(OH)D on training related changes.

scholarly journals Osseus: A Method Based on Artificial Intelligence and Electromagnetic Waves for Ancillary Diagnosis of Osteoporosis

2021 ◽  
Author(s):  
Gabriela Albuquerque¹ ◽  
Agnaldo Cruz¹ ◽  
Dionísio Carvalho¹ ◽  
Nadja Mayrink¹ ◽  
Bruno Pinheiro¹ ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Electromagnetic Waves ◽  
Bone Structure ◽  
Middle Finger ◽  
Health Condition ◽  
Signal Attenuation ◽  
Mineral Density

Abstract Background: Osteoporosis is characterized by low bone mineral density, which causes fractures and compromises people's quality of life. Diagnostic devices for assessing this health condition, such as Dual Energy X-ray Absorptiometry (DXA), are very costly. Therefore, it is impracticable to meet the demand for tests in Brazil's 5,568 municipalities. Given that, we proposed a pre-clinical validation of a prototype developed to aid bone mineral density classification. Thus, Osseus integrates a microcontroller with other peripheral devices to measure the electromagnetic permittivity at the middle phalanx of the middle finger, with two antennas operating in the 2.45 GHz frequency range. Using Artificial Intelligence to identify risk factors alongside signal attenuation measurement indicates the need for DXA. Results: We conducted tests with plaster, Galliformes, and porcine bones. Comparison of the measurements of the original and mechanically altered samples have demonstrated that the device can handle the complexity of the tissues within the bone structure and characterize its microarchitecture. Conclusions: Osseus is a prototype and has been preliminarily validated. There is a lack of validation studies with the reference/gold standard that are currently under development. Osseus enables early detection of osteoporosis, reduces costs, and optimizes high-complexity testing referrals.

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