scholarly journals Paraneoplastic Filiform Hyperkeratosis and Immunoglobulin-Associated Vasculitis in Myeloma Progression: A Case Report

2021 ◽  
pp. 563-567
Author(s):  
Mathias Oymanns ◽  
Mehmet Baltaci ◽  
Aliyah Bellm ◽  
Chalid Assaf
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Early Diagnosis ◽  
Lymphoproliferative Disease ◽  
Skin Involvement ◽  
Associated Symptoms ◽  
Appropriate Therapy

Multiple myeloma is a lymphoproliferative disease, which rarely presents with skin involvement or associated symptoms. Better awareness of these dermatological presentations is required for early diagnosis and to guide the patient towards appropriate therapy. We report on a patient with diffuse filiform hyperkeratosis and immunoglobulin-associated vasculitis in a severe progression of a known myeloma.

Advanced myeloma masquerading as chronic shoulder pain in a 48-year-old man: a diagnostic dilemma

2020 ◽  
Vol 13 (5) ◽  
pp. e231219
Author(s):  
Rajarshi Bhadra ◽  
Teodora Nikova ◽  
Meyappan Somasundaram ◽  
Keyvan Ravakhah
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Early Diagnosis ◽  
Shoulder Pain ◽  
Pathologic Fracture ◽  
Diagnostic Dilemma ◽  
History Of ◽  
Low Threshold ◽  
The Right ◽  
Chronic Shoulder Pain

Although solitary plasmacytomas may occasionally present as collar bone swellings or fractures, multiple myeloma involving clavicle is extremely rare. Ten to forty per cent of multiple myeloma cases are asymptomatic and are incidental diagnoses. Our case report describes an entirely benign presentation like chronic shoulder pain masquerading advanced myeloma, thereby posing a significant diagnostic dilemma. We present a 48-year-old man who presented with chronic bilateral shoulder pain with no history of trauma and was eventually diagnosed with advanced multiple myeloma and pathologic fracture of the right clavicle. It is, therefore, evident that a low threshold for suspicion can lead to early diagnosis and initiation of treatment and better survival.

Neurologic involvement of multiple myeloma. Literature review and case report

1991 ◽  
Vol 81 (4) ◽  
pp. 220-223 ◽  
Author(s):  
SP Sidoti ◽  
FJ Cherpack
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Early Diagnosis ◽  
Literature Review ◽  
Lower Extremity ◽  
Diagnosis And Treatment ◽  
Common Cause ◽  
Neurologic Involvement ◽  
Underlying Malignancy ◽  
Common Causes

A case of malignancy and resultant lower extremity neuropathy is presented. Although not a common cause of such neuropathy, a search should be made for underlying malignancy when more common causes have been ruled out. Early diagnosis and treatment may decrease morbidity and mortality.

Neonatal Serum Electrolyte and Proteinuria Screening on 46,XY Ambiguous Genitalia Patients May Allow Early Diagnosis of Denys-Drash Syndrome: A Case Report

Urology ◽  
2020 ◽  
Author(s):  
Angelena Edwards ◽  
Niccolo M. Passoni ◽  
Rebecca Collins ◽  
Smitha Vidi ◽  
Jyothsna Gattineni ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Ambiguous Genitalia ◽  
Serum Electrolyte ◽  
Drash Syndrome

A case report of concomitant diagnosis of multiple myeloma and primary hyperparathyroidism

2019 ◽  
Author(s):  
Eithar Deyab ◽  
Muhammad Esakji ◽  
Neil Rabin ◽  
Ravi Menon ◽  
Girish Rayanagoudar
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Primary Hyperparathyroidism

Charcot foot: Early diagnosis and interest in medical care: A case report

2020 ◽  
Author(s):  
Ramla Mizouri ◽  
Radhouene Gharbi ◽  
Sonda Sellami ◽  
Ines Kammoun
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Medical Care ◽  
Charcot Foot

Apresentação e Evolução Atípicas da Granulomatose de Wegener: Relato de Caso/Atypical Presentation and Evolution of Wegener's Granulomatosis: Case Report

1970 ◽  
Vol 5 (3) ◽  
pp. 53-67
Author(s):  
Aline Dos Santos ◽  
Ana Caroline Balducci Scafi ◽  
Luciene Azevedo Morais ◽  
Pablo Girardelli Mendonça Mesquita
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Case Report ◽  
Chronic Renal Failure ◽  
Early Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Immunosuppressive Treatment ◽  
Clinical Manifestations ◽  
Wegener's Granulomatosis ◽  
Creatinine Concentration

RESUMOIntrodução: A Granulomatose de Wegener (GW) é uma vasculite rara e idiopática associada à presença do anticorpo Anticitoplasma de Neutrófilo (ANCA) que acomete, preferencialmente, os pequenos vasos. As manifestações clínicas são diversas, ocorrendo em mais de 90% dos casos, sintomas do trato respiratório. O comprometimento renal é tardio e preditor de mau prognóstico.  Sua morbidade a médio e longo prazo inclui insuficiência renal crônica. A probabilidade de sucesso de manutenção da função renal depende da concentração sérica de creatinina ao início do tratamento, o que indica a importância do diagnóstico e terapêutica adequada precoces. Casuística: Relata-se o caso de uma paciente do sexo feminino, 61 anos, portadora de GW com comprometimento renal avançado à apresentação não precedido por sintomas pulmonares esperados. O tratamento imunossupressor associado a plasmaferese permitiu a melhora da função renal da paciente poupando-a de tornar-se dialítica- dependente. Discussão: A paciente iniciou a doença através de insuficiência renal assintomática, com valores de função renal compatíveis com o estágio mais avançado de doença renal crônica, ultrassonografia dos rins sem alterações compatíveis e sem os sintomas respiratórios esperados. Segundo a literatura, a combinação de imunossupressores e plasmaferese associa-se à recuperação renal em três meses com sobrevivência sem necessidade de diálise por 12 meses, no caso relatado, obteve-se tal resultado em 22 dias sem a necessidade de diálise após um ano. Conclusão: Devido ao diagnóstico precoce, o tratamento adequado foi instalado rapidamente proporcionando à paciente um aumento da expectativa e da qualidade de vida, evitando dependência de terapia renal substitutiva.Palavras-Chave: Granulomatose de Wegener, Plasmaferese, Doença renal crônica.  ABSTRACTIntroduction: The Wegener's Granulomatosis (WG) is a rare and idiopathic vasculitis associated with the presence of Antineutrophil Cytoplasmic Antibody (ANCA), that affects, preferentially, the small vessels. The clinical manifestations are diverse, occurring in over 90% of cases, symptoms in the respiratory tract. Kidney damage is a late and bad prognostic predictor. Morbidity in the medium and long term includes chronic renal failure. The probability of renal function maintenance success depends on serum creatinine concentration at the beginning of treatment that indicates the importance of early diagnosis and deployment of an appropriate therapy. Case Report: We present a case of a 61-year-old female patient, carrier of GW with advanced renal impairment presentation, not preceded by expected pulmonary symptoms. The immunosuppressive treatment associated with plasmapheresis allowed the improvement of the patient’s renal function, saving her from becoming dialysis-dependent Discussion: The patient developed the disease through asymptomatic renal failure, renal function with values that are compatible with the most advanced stage of chronic kidney disease, ultrasound of the kidneys without compatible changes and without the expected respiratory symptoms. According to the literature, the combination of immunosuppressive drugs and plasmapheresis is associated with renal recovery in three months with survival without dialysis for 12 months. In this case, a result was obtained in 22 days without the need for dialysis after one year. Conclusion: Due to the early diagnosis, appropriate treatment was quickly installed giving the patient increased life expectancy and quality, preventing dependence on renal replacement therapy.Keywords: Wegener’s granulomatosis, Plasmapheresis, Chronic renal failure.

Daratumumab-Based Therapy for IgM Multiple Myeloma With Hyperviscosity Syndrome: A Case Report

2020 ◽  
Author(s):  
Roberto Mina ◽  
Francesca Bonello ◽  
Francesca Gay ◽  
Elena Zamagni ◽  
Mario Boccadoro
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Hyperviscosity Syndrome
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