Remission of Alopecia Universalis after 1 Year of Treatment with Dupilumab in a Patient with Severe Atopic Dermatitis

2021 ◽  
pp. 1-4
Author(s):  
Maurizio Romagnuolo ◽  
Mauro Barbareschi ◽  
Simona Tavecchio ◽  
Luisa Angileri ◽  
Silvia Mariel Ferrucci
Keyword(s):  
Atopic Dermatitis ◽  
Skin Disorder ◽  
Human Monoclonal Antibody ◽  
Severe Atopic Dermatitis ◽  
T Helper ◽  
T Helper 1 ◽  
Th2 Response ◽  
Alopecia Universalis ◽  
T Helper 2 ◽  
Relapsing Remitting

Alopecia areata (AA), an autoimmune disease with a relapsing-remitting course, represents the second cause of non­scarring alopecia worldwide and is associated with several comorbidities, notably atopic dermatitis (AD). In particular, AD is related to its more severe forms alopecia totalis (AT) and alopecia universalis (AU) [Nat Rev Dis Primers. 2017;3:17011]. Considering that AA has been classified as T helper 1-driven disease, whereas AD is the prototypical T helper 2 (Th2)-driven skin disorder, recent studies suggest that these forms may underlie a different chemokine expression resulting in a Th2 skewing as a key pathomechanism that could explain this association [JAMA Dermatol. 2015 May;151(5):522–8]. Several reports showed that dupilumab, a fully human monoclonal antibody targeting the interleukin 4α receptor and thus downregulating Th2 response, led to an improvement of AA associated with AD; most of these patients were females with AT or AU, early-onset AD, and atopic comorbidities [Exp Dermatol. 2020 Aug;29(8):726–32]. We report here a case to further support this hypothesis.

scholarly journals OX40L–OX40 Signaling in Atopic Dermatitis

2021 ◽  
Vol 10 (12) ◽  
pp. 2578
Author(s):  
Masutaka Furue ◽  
Mihoko Furue
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Memory T Cells ◽  
Effector Memory ◽  
T Helper ◽  
T Helper 1 ◽  
Therapeutic Success ◽  
T Helper 2 ◽  
Promising Target ◽  
Antigen Presenting

OX40 is one of the co-stimulatory molecules expressed on T cells, and it is engaged by OX40L, primarily expressed on professional antigen-presenting cells such as dendritic cells. The OX40L–OX40 axis is involved in the sustained activation and expansion of effector T and effector memory T cells, but it is not active in naïve and resting memory T cells. Ligation of OX40 by OX40L accelerates both T helper 1 (Th1) and T helper 2 (Th2) effector cell differentiation. Recent therapeutic success in clinical trials highlights the importance of the OX40L–OX40 axis as a promising target for the treatment of atopic dermatitis.

Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression

2017 ◽  
Vol 76 (1) ◽  
pp. 91-97.e3 ◽  
Author(s):  
Doris Weiss ◽  
Michaela Schaschinger ◽  
Robin Ristl ◽  
Robert Gruber ◽  
Tamara Kopp ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Severe Atopic Dermatitis ◽  
T Helper ◽  
Down Regulation ◽  
T Helper 2

scholarly journals Review: Lymphocytes, cytokines, chemokines and the T-helper 1-T-helper 2 balance in canine atopic dermatitis

2015 ◽  
Vol 26 (2) ◽  
pp. 124-e32 ◽  
Author(s):  
Cherie M. Pucheu-Haston ◽  
Petra Bizikova ◽  
Rosanna Marsella ◽  
Domenico Santoro ◽  
Tim Nuttall ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Helper ◽  
T Helper 1 ◽  
Canine Atopic Dermatitis ◽  
T Helper 2

scholarly journals Apremilast Use for Moderate-to-Severe Atopic Dermatitis in Pediatric Patients

2016 ◽  
Vol 8 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Rachael C. Saporito ◽  
David J. Cohen
Keyword(s):  
Atopic Dermatitis ◽  
Case Report ◽  
Immunoglobulin E ◽  
Interleukin 4 ◽  
Severe Atopic Dermatitis ◽  
T Helper ◽  
Novel Therapy ◽  
T Helper 2 ◽  
American Children ◽  
Bacterial Superinfection

Atopic dermatitis (AD) is a chronic, pruritic skin disease often complicated by bacterial superinfection affecting 10.7% of American children. The pathogenesis involves a skin barrier breakdown in addition to dysfunctional innate and adaptive immune response, including an unbalanced increase in T-helper 2 cells and hyperimmunoglobulinemia E. The increased numbers of T-helper 2 cells are involved in stimulating the production of immunoglobulin E and eosinophilia by releasing interleukin-4, -5, and -13 as well as in decreasing protection against bacterial superinfection by releasing interleukin-10. The current Food and Drug Administration-approved symptomatic treatment for AD includes topical ointments, topical and systemic corticosteroids, topical immunomodulant therapy, antibiotics, and phototherapy, but there are not approved targeted therapies or cures. By presenting a case of an 8-year-old African-American boy, this case report supports novel therapy of moderate-to-severe AD with apremilast, a phosphodiesterase type 4 inhibitor. Apremilast has recently completed the phase 2 clinical trial (NCT02087943) for treatment of AD in adults. This case report illustrates the potential for apremilast as a treatment for AD in children, where there is a great need for safe and effective medications.

T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis

2002 ◽  
Vol 87 (3-4) ◽  
pp. 379-384 ◽  
Author(s):  
T.J Nuttall ◽  
P.A Knight ◽  
S.M McAleese ◽  
J.R Lamb ◽  
P.B Hill
Keyword(s):  
Atopic Dermatitis ◽  
T Helper ◽  
T Helper 1 ◽  
Canine Atopic Dermatitis ◽  
T Helper 2 ◽  
Immunosuppressive Cytokines

scholarly journals Changes in Maternal Peripheral T Helper 1-Type and T Helper 2-Type Immunity during Labor.

2001 ◽  
Vol 194 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Toyohiko Kuwajima ◽  
Shunji Suzuki ◽  
Rintaro Sawa ◽  
Yoshio Yoneyama ◽  
Toshiyuki Takeshita ◽  
...  
Keyword(s):  
T Helper ◽  
T Helper 1 ◽  
T Helper 2

The Effect of Crocus sativus Extract on Human Lymphocytes' Cytokines and T Helper 2/T Helper 1 Balance

2011 ◽  
Vol 14 (12) ◽  
pp. 1538-1545 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Seyedh Masoumeh Seyedhosseini Tamijani ◽  
Houshang Rafatpanah ◽  
Abadolrahim Rezaei ◽  
Azam Alavinejad
Keyword(s):  
Human Lymphocytes ◽  
Crocus Sativus ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2

scholarly journals Targeting the T Helper 2 Inflammatory Axis in Atopic Dermatitis

2016 ◽  
Vol 171 (2) ◽  
pp. 71-80 ◽  
Author(s):  
Adriana S. Moreno ◽  
Roderick McPhee ◽  
Luisa Karla Arruda ◽  
Michael D. Howell
Keyword(s):  
Atopic Dermatitis ◽  
T Helper ◽  
T Helper 2

scholarly journals Adenosine A 2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function

2008 ◽  
Vol 22 (10) ◽  
pp. 3491-3499 ◽  
Author(s):  
Balázs Csóka ◽  
Leonóra Himer ◽  
Zsolt Selmeczy ◽  
E. Sylvester Vizi ◽  
Pal Pacher ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Cell Development ◽  
Effector Function ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2
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