“Transition” to Schizophrenia or Fluctuations within the Same Disorder?

2021 ◽  
pp. 1-9
Author(s):  
Julie Nordgaard ◽  
Rasmus Handest ◽  
Mads Gram Henriksen ◽  
Anne Vollmer-Larsen ◽  
Peter Handest ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Psychotic Experiences ◽  
Level Of Functioning ◽  
Perceptual Disorders ◽  
Thought Disorders ◽  
The Subject ◽  
Schizotypal Disorder ◽  
Current Terminology ◽  
Distressing Condition

<b><i>Background:</i></b> To prevent or delay the onset of psychotic disorders or ameliorate their course, prodromal research has strived to identify and treat individuals at risk of developing psychosis. While this approach is laudable, it is, however, not entirely unproblematic from clinical and conceptual perspectives. For example, it remains unclear how we are to understand the development from a nonpsychotic, distressing condition such as schizotypal disorder to a psychotic disorder such as schizophrenia? The current terminology on the subject implies either a nonlinear jump (“conversion”) or a more linear progression (“transition”) from one disorder to another. To enrich our understanding of such diagnostic shifts, we examined the psychopathological pictures of patients who “transitioned” from schizotypal disorder to schizophrenia. <b><i>Methods:</i></b> From a larger study on psychopathology, we examined 40 patients who were diagnosed with schizotypal disorder at baseline. At 5-year follow-up, 30 patients maintained the diagnosis of schizotypal disorder, while 10 were re-diagnosed with schizophrenia. We examined detailed descriptions of the 10 patients who progressed to schizophrenia, comparing psychopathology and level of functioning. <b><i>Results:</i></b> The level of functioning decreased slightly from baseline to follow-up in 9 out of 10 patients. Eight patients had previously had micro-psychotic or psychotic experiences. All patients had self-disorders at baseline, and several patients had perceptual disorders. Nine patients had formal thought disorders at baseline. The progression is illustrated by 2 cases. <b><i>Conclusion:</i></b> In this small study, we did not find any striking changes in any of the patients, neither in terms of psychopathological manifestations nor in terms of their level of functioning. Thus, rather than witnessing a genuine “conversion” or “transition” from schizotypal disorder to schizophrenia, we observed dimensional fluctuations within the same condition.

scholarly journals Longitudinal follow-up in acute and transient psychotic disorders and schizophrenia

2005 ◽  
Vol 187 (3) ◽  
pp. 286-287 ◽  
Author(s):  
Frank Pillmann ◽  
Andreas Marneros
Keyword(s):  
Psychotic Disorders ◽  
First Episode ◽  
Control Group ◽  
Level Of Functioning ◽  
General Functioning ◽  
And Gender ◽  
High Level ◽  
Observation Period

SummaryWe prospectively studied the long-term course of individuals with acute and transient psychotic disorders and a control group with positive schizophrenia matched for age and gender. Follow-up investigations using standardised instruments were performed at three time-points covering 7 years after the index episode or 12 years after the first episode. During follow-up, those with positive schizophrenia experienced a deterioration in their general functioning whereas those with acute and transient psychotic disorders retained their high level of functioning. At the end of the observation period, 12 out of 39 (31%) of those with acute and transient psychotic disorders were functioning well without medication compared with 0 out of 38 with positive schizophrenia.

scholarly journals Multiple Network Dysconnectivity in Adolescents with Psychotic Experiences: A Longitudinal Population-Based Study

2020 ◽  
Vol 46 (6) ◽  
pp. 1608-1618
Author(s):  
Aisling O’Neill ◽  
Eleanor Carey ◽  
Niamh Dooley ◽  
Colm Healy ◽  
Helen Coughlan ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Brain Regions ◽  
Population Based ◽  
Psychotic Experiences ◽  
Population Based Study ◽  
Neuroimaging Study ◽  
Multiple Network ◽  
Over Time

Abstract Abnormal functional connectivity (FC, the temporal synchronization of activation across distinct brain regions) of the default mode (DMN), salience (SN), central executive (CEN), and motor (MN) networks is well established in psychosis. However, little is known about FC in individuals, particularly adolescents, reporting subthreshold psychotic experiences (PE) and their trajectory over time. Thus, the aim of this study was to investigate the FC of these networks in adolescents with PE. In this population-based case-control study, 24 adolescents (mean age = 13.58) meeting the criteria for PE were drawn from a sample of 211 young people recruited and scanned for a neuroimaging study, with a follow-up scan 2 years later (n = 18, mean age = 15.78) and compared to matched controls drawn from the same sample. We compared FC of DMN, SN, CEN, and MN regions between PE and controls using whole-brain FC analyses. At both timepoints, the PE group displayed significant hypoconnectivity compared to controls. At baseline, FC in the PE group was decreased between MN and DMN regions. At follow-up, dysconnectivity in the PE group was more widespread. Over time, controls displayed greater FC changes than the PE group, with FC generally increasing between MN, DMN, and SN regions. Adolescents with PE exhibit hypoconnectivity across several functional networks also found to be hypoconnected in established psychosis. Our findings highlight the potential for studies of adolescents reporting PE to reveal early neural correlates of psychosis and support further investigation of the role of the MN in PE and psychotic disorders.

DSM outcomes of psychotic experiences and associated risk factors: 6-year follow-up study in a community-based sample

2018 ◽  
Vol 49 (08) ◽  
pp. 1346-1356 ◽  
Author(s):  
Umut Kırlı ◽  
Tolga Binbay ◽  
Marjan Drukker ◽  
Hayriye Elbi ◽  
Bülent Kayahan ◽  
...  
Keyword(s):  
Family History ◽  
Mood Disorders ◽  
Psychotic Disorder ◽  
Psychotic Disorders ◽  
Composite International Diagnostic Interview ◽  
Risk Indicator ◽  
Psychotic Experiences ◽  
Sampling Frame ◽  
History Of

AbstractBackgroundPsychotic experiences (PEs) may predict a range of common, non-psychotic disorders as well as psychotic disorders. In this representative, general population-based cohort study, both psychotic and non-psychotic disorder outcomes of PE were analysed, as were potential moderators.MethodsAddresses were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighbourhoods at baseline (n = 4011). Participants were interviewed with the Composite International Diagnostic Interview (CIDI) both at baseline and at 6-year follow-up. Participants with PE at baseline were clinically re-interviewed with the SCID-I at follow-up. The role of socio-demographics, characteristics of PE, co-occurrence of mood disorders and family history of mental disorders were tested in the association between baseline PE and follow-up diagnosis.ResultsIn the participants with baseline PE, the psychotic disorder diagnosis rate at follow up was 7.0% – much lower than the rates of DSM-IV mood disorders without psychotic features (42.8%) and other non-psychotic disorders (24.1%). Within the group with baseline PE, female sex, lower socio-economic status, co-occurrence of mood disorders, family history of a mental disorder and persistence of PE predicted any follow-up DSM diagnosis. Furthermore, onset of psychotic v. non-psychotic disorder was predicted by younger age (15–30 years), co-presence of delusional and hallucinatory PE and family history of severe mental illness.ConclusionThe outcome of PE appears to be a consequence of baseline severity of multidimensional psychopathology and familial risk. It may be useful to consider PE as a risk indicator that has trans-diagnostic value.

scholarly journals Disintegration process in disc crushers

2013 ◽  
Vol 59 (No. 3) ◽  
pp. 98-104 ◽  
Author(s):  
P. Vaculík ◽  
J. Maloun ◽  
L. Chládek ◽  
M. Přikryl
Keyword(s):  
Food Industry ◽  
Fractional Composition ◽  
Animal Feed ◽  
Raw Materials ◽  
Specific Energy Consumption ◽  
Low Noise ◽  
Main Process ◽  
Industrial Sectors ◽  
The Subject

Grinding or crushing hard raw materials is usually a primary operation which precedes the follow-up technological processes in a number of industrial sectors. A great variety of machines using different principles of fragmentation are employed in the technology of pulverization. The food industry uses roller mills, in which the main process is the shear grinding. In the animal feed industry impact machines known as hammer mills are often used. In recent years, mills have been employed that use their frontal edges for grinding or crushing during the rotation of one of two adjacent discs. The modern design disc machines used for grinding grain have resulted from long development and their operation has a relatively low noise level with reduced dust. The separation process that occurs in the gap between the active edges of the discs can be described as shear grinding and is currently the subject of attention which is focused on the specific energy consumption and fractional composition of the product of grinding. &nbsp;

Bimbingan Nilai-Nilai Spiritual Di Madrasah Aliyah Mafaza Bantul Yogyakarta

2021 ◽  
Vol 6 (2) ◽  
pp. 1
Author(s):  
Heri Fadli Wahyudi
Keyword(s):  
High School ◽  
Data Analysis ◽  
Human Person ◽  
Religious Values ◽  
Next Generation ◽  
Spiritual Values ◽  
Vertical Relationship ◽  
The Subject ◽  
Descriptive Approach

The cultivation of spiritual values to learners is a very vital step in shaping the characteristics and character of the human person, because the internalization of spiritual values is closely related to the cultivation of religious values, and is part of the formation of adolescent character as the next generation of religion and nation. This research is to find out the process of planting and internalizing spiritual value education conducted at The Senior high school of Mafaza Institute located in the Maguntapan Bantul area of Yogyakarta, while the type in this study is qualitative with a descriptive approach, while the subject in this study is teachers or teachers at this institution as well as some M.A. Mafaza students. While the data collected passes through the process of interviews, observations and documentation which then the author of the data analysis to draw conclusions. The results of this study show the following: 1). The process of planting and internalizing values and spiritual in this institution is carried out with an understanding of the material in the classes. 2). Then as a follow-up in the form of application in programs and activities such as requiring mandatory congregational prayers, sunnah worship and others, there are also activities such as the loving mosque and the the Adiwiata program. So from there it is seen that all aspects in value and spiritual, namely the aspect of Aqidah and Worship become the center of attention in planting to their students. So that it covers everything, either in the pattern of vertical relationship (Servant-Godnya) or horizontal (Servants and Environment).

Sensory gating, neurocognition, social cognition and real-life functioning: a 2-year follow-up of early psychosis

2021 ◽  
pp. 1-13
Author(s):  
Shen Li ◽  
Shi Yu Chan ◽  
Amy Higgins ◽  
Mei-Hua Hall
Keyword(s):  
Psychotic Disorders ◽  
Mixed Model ◽  
Real Life ◽  
Sensory Gating ◽  
Early Psychosis ◽  
Global Functioning ◽  
Chi Square ◽  
Life Functioning ◽  
Inference Test

Abstract Background Diminished sensory gating (SG) is a robust finding in psychotic disorders, but studies of early psychosis (EP) are rare. It is unknown whether SG deficit leads to poor neurocognitive, social, and/or real-world functioning. This study aimed to explore the longitudinal relationships between SG and these variables. Methods Seventy-nine EP patients and 88 healthy controls (HCs) were recruited at baseline. Thirty-three and 20 EP patients completed 12-month and 24-month follow-up, respectively. SG was measured using the auditory dual-click (S1 & S2) paradigm and quantified as P50 ratio (S2/S1) and difference (S1-S2). Cognition, real-life functioning, and symptoms were assessed using the MATRICS Consensus Cognitive Battery, Global Functioning: Social (GFS) and Role (GFR), Multnomah Community Ability Scale (MCAS), Awareness of Social Inference Test (TASIT), and the Positive and Negative Syndrome Scale (PANSS). Analysis of variance (ANOVA), chi-square, mixed model, correlation and regression analyses were used for group comparisons and relationships among variables controlling for potential confounding variables. Results In EP patients, P50 ratio (p < 0.05) and difference (p < 0.001) at 24-month showed significant differences compared with that at baseline. At baseline, P50 indices (ratio, S1-S2 difference, S1) were independently associated with GFR in HCs (all p < 0.05); in EP patients, S2 amplitude was independently associated with GFS (p = 0.037). At 12-month and 24-month, P50 indices (ratio, S1, S2) was independently associated with MCAS (all p < 0.05). S1-S2 difference was a trending predictor of future function (GFS or MCAS). Conclusions SG showed progressive reduction in EP patients. P50 indices were related to real-life functioning.

scholarly journals Total Hip Prostheses in Standing, Sitting and Squatting Positions: An Overview of Our 8 Years Practice Using the EOS Imaging Technology

2015 ◽  
Vol 9 (1) ◽  
pp. 26-44 ◽  
Author(s):  
Jean-Yves Lazennec ◽  
Marc-Antoine Rousseau ◽  
Adrien Brusson ◽  
Dominique Folinais ◽  
Maria Amel ◽  
...  
Keyword(s):  
Innovative Technology ◽  
Hip Prostheses ◽  
Total Hip ◽  
Eos Imaging ◽  
Abnormal Posture ◽  
Total Hip Prostheses ◽  
The Subject ◽  
2D And 3D ◽  
Active Patients

More total hip arthroplasty (THA) is performed worldwide and especially in younger and more active patients compared to earlier decades. One of the focuses of THA research in the future will be on optimizing the radiological follow-up of these patients using 2D and 3D measurements of implants position while reducing the radiation dose delivered. Low-dose EOS® imaging is an innovative slot-scanning radiograph system providing valuable information in patient functional positions (standing, sitting and even squatting positions). EOS has been proven accurate and reliable without significant inconvenience caused by the metallic artifacts of implants. The ability to obtain precise data on implant orientation according to the patient posture opens new perspectives for a comprehensive analysis of the pelvic frontal and sagittal balance and its potential impact on implants function and failures. We report our 8 years experience on our first 300 THA patients using this technology routinely for pre and post op evaluation. Our results will be compared and confronted with the actual literature about this innovative technology. We shall especially emphasize our experience about patients with abnormal posture and the evolution of the subject over time, because the phenomenon of an aging spine is frequently associated with the process of aging hips.

scholarly journals Diagnostic stability in a Dutch psychosis incidence cohort

2004 ◽  
Vol 185 (6) ◽  
pp. 460-464 ◽  
Author(s):  
Natalie D. Veen ◽  
Jean-Paul Selten ◽  
Diede Schols ◽  
Winfried Laan ◽  
Hans W. Hoek ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Population Based ◽  
Schizophrenic Disorder ◽  
Diagnostic Stability ◽  
Face To Face ◽  
Follow Up Study ◽  
Relative Risks ◽  
Diagnostic Interviews ◽  
The Uk

BackgroundNo study outside the UK has examined the diagnostic stability of psychotic disorders in a population-based sample.AimsTo determine diagnostic stability in a Dutch population-based psychosis incidence cohort, to examine the frequencies of diagnostic shifts to and from schizophrenic disorders and to report the revised relative risks of schizophrenic disorders for immigrants.MethodA 30-month follow-up study assessed the cohort (n=181) by means of face-to-face diagnostic interviews.ResultsDiagnostic stability of schizophrenic disorders was high (91%), but lower for other psychotic disorders. At follow-up, the initial diagnosis was adjusted to schizophrenic disorder more often than that the reverse occurred. Almost half (49%) of the patients who were not initially diagnosed as having a schizophrenic disorder received this diagnosis at follow-up. The relative risks for most immigrant groups were stable.ConclusionsSchizophrenic disorders are underdiagnosed, rather than overdiagnosed, at first presentation.

scholarly journals Association of frailty in hospitalized and institutionalized elderly in the community-dwelling

2016 ◽  
Vol 69 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Suzele Cristina Coelho Fabrício-Wehbe ◽  
Rosalina Aparecida Partezani Rodrigues ◽  
Vanderlei Jose Haas ◽  
Jack Roberto Silva Fhon ◽  
Marina Aleixo Diniz
Keyword(s):  
Demographic Data ◽  
Functional Independence Measure ◽  
Functional Independence ◽  
Sampling Procedure ◽  
Community Dwelling ◽  
Specific Data ◽  
Follow Up Study ◽  
Dual Stage ◽  
The Subject

ABSTRACT Objective: to investigate the association between frailty with hospitalization and institutionalization in a follow-up study of elderly residents. Method: the follow-up study was performed in 2008 and 2013 with elderly of both genders, aged 65 years and older who were living in the community-dwelling. The sampling procedure performed was probabilistic, with dual-stage clustering. In 2008, 515 elderly people were interviewed and, in 2013, 262. We used the socioeconomic and demographic data, self-reported morbidity, specific data of hospitalization and institutionalization. Frailty was measured by the Edmonton Frail Scale (EFS), and functional capacity through the Functional Independence Measure. Results: we found the mean gross EFS score was higher among resident elderly who were hospitalized and institutionalized and was statistically significant in both investigated years. Conclusion: the confirmation of association between frailty and hospitalization and institutionalization reinforces the importance of the subject, and highlights frailty as an important tool for risk estimates for these adverse events.

Social Support and Post Hospital Outcome for Depressed Women

1983 ◽  
Vol 28 (8) ◽  
pp. 612-618 ◽  
Author(s):  
P. Goering ◽  
D. Wasylenki ◽  
W. Lancee ◽  
S.J.J. Freeman
Keyword(s):  
Social Support ◽  
Social Functioning ◽  
Social Adjustment ◽  
Psychotic Disorders ◽  
Aftercare Services ◽  
Hospital Outcome ◽  
Follow Up Study ◽  
Poor Outcome ◽  
Discharged Patients

In a larger follow-up study of discharged patients, a subgroup of 87 women with non-psychotic disorders had an unexpectedly poor outcome at six months with regard to readmissions, symptoms and social adjustment. The only factor which distinguished those who had been readmitted was lack of social support. Lack of social support was also related to poor symptom and social adjustment outcomes. There were considerable difficulties with social functioning independent of high symptoms. The adequacy of aftercare services is questioned in the light of these findings.

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