scholarly journals The Study of Association between Laryngopharyngeal Reflux and Vocal Fold Leukoplakia Requires Pepsin and Bile Salt Tissue Analyses

ORL ◽  
2021 ◽  
pp. 1-2
Author(s):  
Jérôme R. Lechien ◽  
Marta P. Circiu ◽  
Stéphane Hans ◽  
Sven Saussez
Keyword(s):  
Bile Salt ◽  
Vocal Fold ◽  
Laryngopharyngeal Reflux ◽  
Vocal Fold Leukoplakia

Detecting Laryngopharyngeal Reflux by Immunohistochemistry of Pepsin in the Biopsies of Vocal Fold Leukoplakia

2018 ◽  
Vol 32 (3) ◽  
pp. 352-355 ◽  
Author(s):  
Xia Gong ◽  
Xiao-Yun Wang ◽  
Li Yang ◽  
Ming-Jun Sun ◽  
Jun Du ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Laryngopharyngeal Reflux ◽  
Vocal Fold Leukoplakia

Association between Laryngopharyngeal Reflux and Vocal Fold Leukoplakia

ORL ◽  
2021 ◽  
Vol 83 (3) ◽  
pp. 159-166
Author(s):  
Guowei Lu ◽  
Xiu Ding ◽  
Wen Xu
Keyword(s):  
Risk Factors ◽  
Odds Ratio ◽  
Vocal Fold ◽  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Critical Role ◽  
Heavy Drinking ◽  
General Information ◽  
Underlying Mechanisms ◽  
Vocal Fold Leukoplakia

<b><i>Introduction:</i></b> Vocal fold leukoplakia (VFL) has a risk of malignant transformation, and the underlying mechanisms are currently unrecognized. Some clinical evidence has indicated that laryngopharyngeal reflux (LPR) probably plays a critical role. <b><i>Objective:</i></b> To explore the risk factors associated with the occurrence of VFL and to investigate the importance of LPR in VFL and its different pathological types using 24-h multichannel intraluminal impedance-pH monitoring. <b><i>Materials and Methods:</i></b> Eighty-one patients with VFL and 27 healthy volunteers were recruited. General information and LPR parameters were analyzed. <b><i>Results:</i></b> The monitoring showed that 35.8% (29/81) of patients had acidic LPR and that 43.2% (35/81) had weakly acidic LPR. Heavy drinking (odds ratio = 4.004, <i>p</i> = 0.037) and acidic LPR (odds ratio = 4.471, <i>p</i> = 0.029) were independent risk factors for the occurrence of VFL. Acidic LPR showed a strong correlation with the Reflux Finding Score (<i>p</i> &#x3c; 0.05) in patients suspected of having LPR based on the scale score. Meanwhile, weakly acidic LPR parameters increased with the severity of pathological degrees which were higher in high-grade dysplasia (<i>p</i> &#x3c; 0.05). <b><i>Conclusion:</i></b> Our study confirms the importance of LPR in VFL. Heavy drinking patients with VFL, particularly those with acidic LPR, should undergo intensive treatment. Meanwhile, weakly acidic LPR may play a critical role in the pathological changes in VFL.

Recurrence of vocal fold leukoplakia after carbon dioxide laser therapy

2017 ◽  
Vol 274 (9) ◽  
pp. 3429-3435 ◽  
Author(s):  
Min Chen ◽  
Jian Chen ◽  
Lei Cheng ◽  
Haitao Wu
Keyword(s):  
Carbon Dioxide ◽  
Laser Therapy ◽  
Vocal Fold ◽  
Carbon Dioxide Laser ◽  
Vocal Fold Leukoplakia

scholarly journals Case of a large myofibroblastic laryngeal tumor in a patient with recurrent vocal fold leukoplakia

2020 ◽  
Vol 19 (1) ◽  
pp. 98-104
Author(s):  
M. A. Ryabova ◽  
◽  
M. Yu. Ulupov ◽  
A. G. Tyurin ◽  
D. M. Danilova ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Laryngeal Tumor ◽  
Vocal Fold Leukoplakia

Elevated peripheral inflammatory markers are related with the recurrence and canceration of vocal fold leukoplakia

2019 ◽  
Vol 276 (10) ◽  
pp. 2857-2864 ◽  
Author(s):  
Yi Fang ◽  
Yue Yang ◽  
Min Chen ◽  
Peijie He ◽  
Lei Cheng ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Vocal Fold ◽  
Vocal Fold Leukoplakia

Candidiasis Causing Vocal Fold Leukoplakia: Review of Clinical and Pathological Results of 289 Cases With Vocal Fold Leukoplakia

2019 ◽  
Vol 128 (10) ◽  
pp. 903-910 ◽  
Author(s):  
Murat Gumussoy ◽  
Ulku Kucuk
Keyword(s):  
Vocal Fold ◽  
Inhaled Corticosteroids ◽  
Medical Center ◽  
Age Groups ◽  
Significant Risk ◽  
Case Series ◽  
Predisposing Factors ◽  
Retrospective Case ◽  
Vocal Fold Leukoplakia

Objective: In laryngology practice, vocal fold leukoplakia is frequently evaluated by suspension laryngoscopy and biopsy examination upon the patient’s complaints of hoarseness and dysphonia. The purpose of the present study is to investigate and analyze risk factors, diagnosis, treatment, and follow-up results of cases with Candida leukoplakia. Study Design: Retrospective case control study. Setting: Tertiary medical center. Subjects and Methods: Patients with a diagnosis of vocal fold leukoplakia who underwent direct laryngoscopy and biopsy between 2007 and 2017 and diagnosed as candida or noncandida in their histopathology were assigned into 2 groups. Then they were compared in terms of their demographic characteristics, predisposing factors, diagnosis, treatment, and follow-up results. Results: Of the 289 vocal fold leukoplakia cases, 36 were candida, and 253 were noncandida. The mean age of the patients with Candida leukoplakia was 60.86 years. As for the age groups, the largest group (26.1%) was in the seventh decade ( P < .001). The use of inhaled corticosteroids was a significant risk factor ( P < .001). For their medical therapy, the patients were administered fluconazole 200 mg per day for 3 weeks, and the treatment yielded successful results in 91.66% of them. In 5 of the patients, candida leukoplakia and superficial epithelial dysplasia were observed, and no malignant transformation was observed during a mean follow-up of 28 ± 13 months. Conclusion: Candidiasis causing vocal fold leukoplakia is rare, and we report the findings of the largest published case series to date. Eliminating predisposing factors and administrating oral fluconazole 200 mg for 3 weeks are sufficient for medical treatment.

scholarly journals A morphological classification for vocal fold leukoplakia

2019 ◽  
Vol 85 (5) ◽  
pp. 588-596 ◽  
Author(s):  
Min Chen ◽  
Changjiang Li ◽  
Yue Yang ◽  
Lei Cheng ◽  
Haitao Wu
Keyword(s):  
Vocal Fold ◽  
Morphological Classification ◽  
Vocal Fold Leukoplakia

Glycogenic Acanthosis: An Unusual Cause of Vocal Fold Leukoplakia

2021 ◽  
Author(s):  
Andrea M. Plawecki ◽  
Christian E. Keller ◽  
Ross M. Mayerhoff
Keyword(s):  
Vocal Fold ◽  
Vocal Fold Leukoplakia
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