scholarly journals Prognostic and Clinicopathologic Significance of Discoidin Domain Receptors in Different Human Malignancies: A Meta-Analysis

2021 ◽  
pp. 1-10
Author(s):  
Gordon A. Ferns ◽  
Sheida Shabanian ◽  
Milad Shahini Shams Abadi ◽  
Ahmadshah Farhat ◽  
Mohammad-Hassan Arjmand
Keyword(s):  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Meta Analysis ◽  
Cancer Type ◽  
Prognostic Effect ◽  
Discoidin Domain Receptors ◽  
Physiological Processes ◽  
Urological Cancers ◽  
Different Types ◽  
English Articles

<b><i>Background:</i></b> Discoidin domain receptors (DDRs) belong to the receptor tyrosine kinases family and are activated by different types of collagens, which play roles in various physiological processes. An abnormal expression of DDRs is reported in different types of cancers. Despite many reports about the association and roles of high DDR expression levels in cancers, the prognostic values of DDRs are still unclear. This meta-analysis was performed to evaluate the prognostic effect of DDRs in different tissue cancers. <b><i>Method:</i></b> A literature search was performed in several related databases to find eligible English articles. Based on our research, 20 appropriate studies with 2,602 patients were selected till October 5, 2020. The pooled hazard ratio (HR) with a corresponding 95% confidence interval (CI) was computed to evaluate the strength of correlation between DDRs and survival of cancer patients. <b><i>Result:</i></b> Pooling results showed that a high DDR expression was significantly associated with poorer overall survival (OS) (HR = 1.304, 95% CI 1.007–1.69, <i>p</i> = 0.04). Subgroup analysis based on cancer type revealed a significant link between a high DDR expression level and poor OS both in gastrointestinal (pooled HR = 1.78, 95% CI 1.214–2.624, <i>p</i> = 0.003) and urological cancers (pooled HR = 1.42, 95% CI 1.062–1.82, <i>p</i> = 0.018). <b><i>Conclusion:</i></b> Our meta-analysis results suggest that high DDRs expression has the potential to be used as a biomarker of poor prognosis in cancers.

scholarly journals Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis

2017 ◽  
Vol 52 (10) ◽  
pp. 651-658 ◽  
Author(s):  
Roger Hilfiker ◽  
Andre Meichtry ◽  
Manuela Eicher ◽  
Lina Nilsson Balfe ◽  
Ruud H Knols ◽  
...  
Keyword(s):  
Systematic Review ◽  
Resistance Training ◽  
Cancer Treatment ◽  
Meta Analysis ◽  
Cancer Type ◽  
Cancer Related Fatigue ◽  
Different Types ◽  
After Cancer ◽  
Indirect Comparisons ◽  
Pharmaceutical Interventions

AimTo assess the relative effects of different types of exercise and other non-pharmaceutical interventions on cancer-related fatigue (CRF) in patients during and after cancer treatment.DesignSystematic review and indirect-comparisons meta-analysis.Data sourcesArticles were searched in PubMed, Cochrane CENTRAL and published meta-analyses.Eligibility criteria for selecting studiesRandomised studies published up to January 2017 evaluating different types of exercise or other non-pharmaceutical interventions to reduce CRF in any cancer type during or after treatment.Study appraisal and synthesisRisk of bias assessment with PEDro criteria and random effects Bayesian network meta-analysis.ResultsWe included 245 studies. Comparing the treatments with usual care during cancer treatment, relaxation exercise was the highest ranked intervention with a standardisedmean difference (SMD) of −0.77 (95% Credible Interval (CrI) −1.22 to −0.31), while massage (−0.78; −1.55 to −0.01), cognitive–behavioural therapy combined with physical activity (combined CBT, −0.72; −1.34 to −0.09), combined aerobic and resistance training (−0.67; −1.01 to −0.34), resistance training (−0.53; −1.02 to −0.03), aerobic (−0.53; −0.80 to −0.26) and yoga (−0.51; −1.01 to 0.00) all had moderate-to-large SMDs. After cancer treatment, yoga showed the highest effect (−0.68; −0.93 to −0.43). Combined aerobic and resistance training (−0.50; −0.66 to −0.34), combined CBT (−0.45; −0.70 to −0.21), Tai-Chi (−0.45; −0.84 to −0.06), CBT (−0.42; −0.58 to −0.25), resistance training (−0.35; −0.62 to −0.08) and aerobic (−0.33; −0.51 to −0.16) showed all small-to-moderate SMDs.ConclusionsPatients can choose among different effective types of exercise and non-pharmaceutical interventions to reduce CRF.

scholarly journals Recent Advances in the Therapeutic Development of Receptor Tyrosine Kinases (RTK) against Different Types of Cancer

2021 ◽  
Author(s):  
Somi Patranabis
Keyword(s):  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Therapeutic Strategies ◽  
Cellular Functions ◽  
Recent Advances ◽  
Different Types ◽  
Therapeutic Development ◽  
Potential Applications ◽  
Specific Ligand ◽  
Novel Therapeutic

Receptor Tyrosine Kinases (RTKs) are an important class of receptors involved in regulating different cellular functions. The usual pathway of RTK activation involves specific ligand binding, dimerization and trans-autophosphorylation. Recently, RTK has been extensively studied as they have potential applications in targeted cancer therapy. RTK-based therapeutic strategies are promising because dysfunction of RTK is connected to a variety of diseases. More specifically, RTK has been widely associated with different types of cancer and related diseases. The chapter aims to cover recent advances and challenges in RTK related research, to get an overview of the problems and possibilities associated with targeted therapy. This will help in deciphering novel therapeutic applications in the future.

scholarly journals Prognostic significance of pretreatment controlling nutritional status score in urological cancers: a systematic review and meta‐analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xinhao Niu ◽  
Zhe Zhu ◽  
Juan Bao
Keyword(s):  
Nutritional Status ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Prognostic Indicator ◽  
Cochrane Library ◽  
Cancer Type ◽  
Cancer Specific Survival ◽  
Urological Cancers ◽  
The Cochrane Library ◽  
Conut Score

Abstract Background Controlling Nutritional Status (CONUT) score is a novel nutrition-based biomarker that has been reported for predicting survival in various cancers. However, the relationship between CONUT score and prognosis of urological cancers remains unclear. Hence, we performed this meta-analysis to evaluate the prognostic significance of CONUT score for patients with urological cancers. Methods PubMed, Embase, the Cochrane Library and National Knowledge Infrastructure (CNKI) were systematically searched up to October 2020. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the association of CONUT score with overall survival (OS), cancer-specific survival (CSS) and recurrence/disease/progress-free survival (RFS/DFS/PFS) in urological cancers. Results A total of 12 articles with 13 studies were included in the analysis. Pooled results indicated that increased CONUT score predicted poor OS (HR: 1.78, 95% CI 1.51–2.09, p < 0.001), CSS (HR: 2.14, 95% CI 1.55–2.97, p < 0.001) and RFS/DFS/PFS (HR: 1.57, 95% CI 1.35–1.84, p < 0.001). Subgroup analysis by cancer type revealed that high CONUT score associated with worse OS in renal cell carcinoma (RCC) and urothelial cancer (UC) (HR: 3.05, 95% CI 2.07–4.50, p < 0.001; HR: 1.58, 95% CI 1.32–1.89, p < 0.001). Similar results could be found in CSS (RCC HR: 2.67, 95% CI 1.87–3.81, p < 0.011; UC HR: 1.68, 95% CI 1.09–2.59, p = 0.011) and in RFS/DFS/PFS (RCC HR: 1.96, 95% CI 1.44–2.66, p < 0.001; UC HR: 1.42, 95% CI 1.18–1.71, p < 0.001). Conclusions These results illustrated that the high CONUT score may predict worse survival for patients suffering from urological cancers. Therefore, the CONUT score may represent an effective prognostic indicator in urological cancers.

scholarly journals Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling

2013 ◽  
Vol 288 (11) ◽  
pp. 7430-7437 ◽  
Author(s):  
Hsueh-Liang Fu ◽  
Rajeshwari R. Valiathan ◽  
Richard Arkwright ◽  
Anjum Sohail ◽  
Cosmin Mihai ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Discoidin Domain Receptors
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