scholarly journals Oncologists’ Perceptions of Tumor Genomic Profiling and the Communication of Test Results and Risks

2021 ◽  
pp. 1-6
Author(s):  
Michael J. Hall ◽  
Paul D’Avanzo ◽  
Yana Chertock ◽  
Jesse Brajuha ◽  
Sarah B. Bass
Keyword(s):  
Self Efficacy ◽  
Genomic Profiling ◽  
Test Results ◽  
Communication Research ◽  
Cancer Treatments ◽  
Training Tool ◽  
Practice Experience ◽  
Medical Oncologists ◽  
And Training ◽  
High Median

Tumor genomic profiling (TGP) identifies genetic targets for precision cancer treatments. The complexity of TGP can expose gaps in oncologists’ skills, complicating test interpretation and patient communication. Research on oncologists’ use and perceptions of TGP could inform practice patterns and training needs. To study this, a sample of oncologists was surveyed to assess TGP use, perceptions, and perceived skills in TGP interpretation/communication, especially in communication of hereditary risks. Genomic self-efficacy and TGP knowledge were also assessed. The goal sample (<i>n</i> = 50) was accrued from 12/2019 to 1/2020. Respondents were primarily medical oncologists (78%) with &#x3e;10 (mean 17.7) years of practice experience. TGP use was moderate/high (median 50 [range 2–398]) tests/year. Most oncologists reported informal/no training in interpretation (72%) or communication (86%) of TGP results and risks. Genomic self-efficacy was high and was associated with higher use of TGP (<i>p</i> = 0.047). Perceptions of the benefits and limitations of TGP were mixed: heterogeneity was seen by years of experience, TGP use, and knowledge. Most participants agreed that additional training in TGP communication was needed, especially in communication of hereditary risks, and that an online training tool would be useful (86%). We conclude that oncologists are frequently using TGP despite having mixed views about its utility and not feeling prepared to communicate risks to patients. Oncologists receive little education in interpreting TGP or communicating its results and risks, and would value training in this area.

scholarly journals Differential Effects of Up- and Down-Regulation of SMR Coherence on EEG Activity and Memory Performance: A Neurofeedback Training Study

2020 ◽  
Vol 14 ◽  
Author(s):  
Silvia Erika Kober ◽  
Christa Neuper ◽  
Guilherme Wood
Keyword(s):  
Memory Performance ◽  
Eeg Coherence ◽  
Test Results ◽  
Practical Application ◽  
Neurofeedback Training ◽  
Eeg Activity ◽  
Memory Functions ◽  
Training Tool ◽  
Post Test ◽  
And Training

Modulating connectivity measures in EEG-based neurofeedback studies is assumed to be a promising therapeutic and training tool. However, little is known so far about its effects and trainability. In the present study, we investigated the effects of up- and down-regulating SMR (12–15 Hz) coherence by means of neurofeedback training on EEG activity and memory functions. Twenty adults performed 10 neurofeedback training sessions in which half of them tried to increase EEG coherence between Cz and CPz in the SMR frequency range, while the other half tried to down-regulate coherence. Up-regulation of SMR coherence led to between- and within-session changes in EEG coherence. SMR power increased across neurofeedback training sessions but not within training sessions. Cross-over training effects on baseline EEG measures were also observed in this group. Up-regulation of SMR coherence was also associated with improvements in memory functions when comparing pre- and post-test results. Participants were not able to down-regulate SMR coherence. This group did not show any changes in baseline EEG measures or memory functions comparing pre- and post-test. Our results provide insights in the trainability and effects of connectivity-based neurofeedback training and indications for its practical application.

Development of the Training Equipment for the Output Characteristics of PV Module

2013 ◽  
Vol 291-294 ◽  
pp. 188-193
Author(s):  
Yan Zhang ◽  
Meng Chao Ma ◽  
Shi Tao Wang ◽  
Yi Shu Zhao
Keyword(s):  
Real Time ◽  
Solar Panel ◽  
Partial Function ◽  
Test Results ◽  
Training Tool ◽  
Operational Principle ◽  
Pv Module ◽  
Output Characteristics ◽  
Pv Generation ◽  
And Training

In order to meet the needs of experiments, teaching and training on output characteristics of PV solar panel, this paper designed and produced a real-time training experimental box to test the output characteristics of the PV module, basing on the principle and characteristics of the PV generation .The partial function of the experimental box is designed according to the operational principle of the PV streetlight. So it may be used combining with PV module or PV streetlight. It is a teaching and training tool to carry out appropriate experiments. The photovoltaic output characteristics have been verified by the test results on the equipment.

scholarly journals COT-13 Current situation and problems of cancer genomic profiling test in Kyoto University Hospital

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii22-ii22
Author(s):  
Yoshiki Arakawa ◽  
Junko Suga ◽  
Yukinori Terada ◽  
Kohei Nakajima ◽  
Masahiro Tanji ◽  
...  
Keyword(s):  
Treatment Options ◽  
Insurance Coverage ◽  
Germline Mutations ◽  
University Hospital ◽  
Genomic Profiling ◽  
Test Results ◽  
Final Test ◽  
First Time ◽  
To Receive ◽  
Secondary Finding

Abstract Objective: Kyoto University Hospital has introduced the cancer genomic profiling tests, Oncoprime in 2015, Guardant360 in 2018, which are not under insurance coverage, FoundationOne CDx(F1CDx) and OncoGuide NCC Oncopanel system(NCC OP) in 2019, which received approval for insurance coverage for the first time in Japan. We investigated the results of cancer genomic profiling test under insurance coverage in our hospital. Methods: A special facility for the cancer genomic profiling tests was produced. To perform the cancer genomic profiling test, an outpatient must visit the facility three times (learning, ordering of the test, and getting the results). The expert panels decide the final test results and treatment options with the all information of the patients. Results: From November 2019 to March 2020, 51 and 9 patients were tested with F1CDx and NCC OP, respectively. 16 patients (31%) of F1CDX and 2 patients (22%) of NCC OP got treatment recommendations from the expert panels. However, only 5 patients (9.8%) of F1CDX and 1 patient (11%) of NCC OP received the treatments. The secondary finding suspecting germline mutations was found in 8 patients of F1CDX. Conclusion: After the approval the cancer genomic profiling tests with insurance coverage in Japan, it becomes easy for the patients to perform the test and get the genetic information of the tumor. However, it remains not easy to receive the recommended drugs because of several limitations of their usages.

scholarly journals Functional Translation of Exercise Responses from Exercise Testing to Exercise Training: The Test of a Model

2021 ◽  
Vol 6 (3) ◽  
pp. 66
Author(s):  
Tristan Tyrrell ◽  
Jessica Pavlock ◽  
Susan Bramwell ◽  
Cristina Cortis ◽  
Scott T. Doberstein ◽  
...  
Keyword(s):  
Exercise Testing ◽  
Exercise Test ◽  
Perceived Exertion ◽  
Exercise Prescription ◽  
Test Results ◽  
Training Intensity ◽  
Ratings Of Perceived Exertion ◽  
Metabolic Equivalents ◽  
Cardiovascular Drift ◽  
And Training

Exercise prescription based on exercise test results is complicated by the need to downregulate the absolute training intensity to account for cardiovascular drift in order to achieve a desired internal training load. We tested a recently developed generalized model to perform this downregulation using metabolic equivalents (METs) during exercise testing and training. A total of 20 healthy volunteers performed an exercise test to define the METs at 60, 70, and 80% of the heart rate (HR) reserve and then performed randomly ordered 30 min training bouts at absolute intensities predicted by the model to achieve these levels of training intensity. The training HR at 60 and 70% HR reserve, but not 80%, was significantly less than predicted from the exercise test, although the differences were small. None of the ratings of perceived exertion (RPE) values during training were significantly different than predicted. There was a strong overall correlation between predicted and observed HR (r = 0.88) and RPE (r = 0.52), with 92% of HR values within ±10 bpm and 74% of RPE values within ±1 au. We conclude that the generalized functional translation model is generally adequate to allow the generation of early absolute training loads that lead to desired internal training loads.

Peritonsillar abscess drainage: using oropharyngeal endoscopy as a therapeutic adjunct and training tool

2021 ◽  
Vol 135 (2) ◽  
pp. 176-178 ◽  
Author(s):  
A Sawhney ◽  
R Bidaye ◽  
A Khanna
Keyword(s):  
Peritonsillar Abscess ◽  
Therapeutic Procedure ◽  
Deep Tissue ◽  
Abscess Drainage ◽  
Incision And Drainage ◽  
Training Tool ◽  
Poor Access ◽  
The Uk ◽  
And Training ◽  
Poor Lighting

AbstractBackgroundPeritonsillar abscess, or quinsy, is one of the most common emergency presentations to ENT departments, and is the most common deep tissue infection of the head and neck. In the UK, junior members of the ENT team are regularly required to independently assess, diagnose and treat patients with peritonsillar aspiration or incision and drainage.IssueInexperienced practitioners can stumble at several obstacles: poor access due to trismus; poor lighting; difficulty in learning the therapeutic procedure; and difficulty in accurately documenting findings and treatment.SolutionTo counter these and other difficulties, the authors describe the routine use of video endoscopy as a training tool and therapeutic adjunct in the management of quinsy.

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