scholarly journals Recurrent Hypocalcemic Tetany as the Initial Presentation in Some Persons with Hyperthyroidism: A Case Series

2021 ◽  
pp. 1-4
Author(s):  
Yakubu Lawal ◽  
Umar Faruk Dahuwa ◽  
Ibrahim Abdullahi ◽  
Felicia Ehusani Anumah
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Calcium Metabolism ◽  
Clinical Presentation ◽  
Case Series ◽  
Initial Presentation ◽  
Calcium Balance ◽  
Mineral Density ◽  
Resource Poor ◽  
Laboratory Investigations

This is a case series of recurrent hypocalcemic tetany as the initial presentation in some cases of hyperthyroidism. Literature review has revealed more reports of hypercalcemia than hypocalcemia as a feature of hyperthyroidism. The recurrence of hypocalcemic tetany in the 3 cases reported ceased following the treatment of hyperthyroidism. The aim of this case series is to alert clinicians to the fact that hypocalcemic tetany can be the initial clinical presentation of hyperthyroidism. It also highlights the resilience of managing endocrine patients in resource-poor settings with the aid of high clinical acumen and fewer-than-expected laboratory investigations. Further research is needed to investigate our hypothesis that disordered calcium metabolism in thyrotoxicosis may manifest in successive phases of hypercalcemia-normocalcemia-hypocalcemia. The rate at which individual thyrotoxic patient traverses these phases may be directly proportional to the background vitamin D deficiency, negative calcium balance, and bone mineral density.

Calcium metabolism, vitamin D and bone mineral density after bariatric surgery

2014 ◽  
Vol 26 (2) ◽  
pp. 757-764 ◽  
Author(s):  
T. L. Costa ◽  
M. Paganotto ◽  
R. B. Radominski ◽  
C. M. Kulak ◽  
V. C. Borba
Keyword(s):  
Bone Mineral Density ◽  
Bariatric Surgery ◽  
Vitamin D ◽  
Bone Mineral ◽  
Calcium Metabolism ◽  
Mineral Density

scholarly journals Sarcoidosis and calcium homeostasis disturbances—Do we know where we stand?

2019 ◽  
Vol 16 ◽  
pp. 147997311987871 ◽  
Author(s):  
Łukasz Gwadera ◽  
Adam Jerzy Białas ◽  
Mikołaj Aleksander Iwański ◽  
Paweł Górski ◽  
Wojciech Jerzy Piotrowski
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Calcium Homeostasis ◽  
Calcium Metabolism ◽  
Vitamin D Supplementation ◽  
Vitamin D Metabolites ◽  
Activated Macrophages ◽  
Mineral Density ◽  
Metabolism Disorder

The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.

scholarly journals Modulation of Vitamin D Status and Dietary Calcium Affects Bone Mineral Density and Mineral Metabolism in Göttingen Minipigs

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Katharina E. Scholz-Ahrens ◽  
Claus-Christian Glüer ◽  
Felix Bronner ◽  
Günter Delling ◽  
Yahya Açil ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Large Animal Model ◽  
Control Group ◽  
Large Animal ◽  
Calcium Balance ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Large Animal Models

Calcium and vitamin D deficiency impairs bone health and may cause rickets in children and osteomalacia in adults. Large animal models are useful to study experimental osteopathies and associated metabolic changes. We intended to modulate vitamin D status and induce nutritional osteomalacia in minipigs. The control group (n = 9) was fed a semisynthetic reference diet with 6 g calcium and 6,500 IU vitamin D3/kg and the experimental group (n = 10) the same diet but with only 2 g calcium/kg and without vitamin D. After 15 months, the deficient animals were in negative calcium balance, having lost bone mineral density significantly (means ± SEM) with −51.2 ± 14.7 mg/cm3 in contrast to controls (−2.3 ± 11.8 mg/cm3), whose calcium balance remained positive. Their osteoid surface was significantly higher, typical of osteomalacia. Their plasma 25(OH)D dropped significantly from 60.1 ± 11.4 nmol/L to 15.3 ± 3.4 nmol/L within 10 months, whereas that of the control group on the reference diet rose. Urinary phosphorus excretion and plasma 1,25-dihydroxyvitamin D concentrations were significantly higher and final plasma calcium significantly lower than in controls. We conclude that the minipig is a promising large animal model to induce nutritional osteomalacia and to study the time course of hypovitaminosis D and associated functional effects.

Vitamin D receptor Bsm1 polymorphism, calcium metabolism and bone mineral density in patients with multiple sclerosis: a pilot study

2012 ◽  
Vol 34 (8) ◽  
pp. 1433-1439 ◽  
Author(s):  
Irene Lambrinoudaki ◽  
Elias Patikas ◽  
George Kaparos ◽  
Eleni Armeni ◽  
Demetrios Rizos ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Bone Mineral Density ◽  
Vitamin D ◽  
Pilot Study ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Calcium Metabolism ◽  
Mineral Density

Inadequate vitamin D status adversely affects trabecular bone mineral density in 14-18 year old adolescents

2017 ◽  
Author(s):  
Taryn Smith ◽  
Laura Tripkovic ◽  
Camilla Damsgaard ◽  
Christian Molgaard ◽  
Aine Hennessy ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Trabecular Bone Mineral Density

Bone mineral density and vitamin D status in children with chronic neurological syndromes - clinical observations

2019 ◽  
Author(s):  
Elzbieta Jakubowska-Pietkiewicz ◽  
Maciej Porczynski ◽  
Ewa Rychlowska ◽  
Paulina Albinska ◽  
Elzbieta Wozniak ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Clinical Observations

Influence of vitamin D deficiency on the bone mineral density in schoolchildren

2015 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Nataliya Balatska ◽  
Olga Tyazhka ◽  
Tetiana Budnik ◽  
Inga Kubey ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Mineral Density
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