scholarly journals Identification of Two Similar Novel HIV-1 Recombinant Forms (CRF01_AE/CRF07_BC) among Intravenous Drug Users in Guangxi, China

Intervirology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Fei Zhang ◽  
Yao Yang ◽  
Bingyu Liang ◽  
Yuan Yang ◽  
Qiuyu Wei ◽  
...  

New kinds of HIV-1 circulating recombinant forms (CRFs) and unique recombinant forms (URFs) earn a great prevalence in China nowadays. In this study, we identified 2 similar URFs (2016GXNNIDU037 and 2019QZLSIDU253) both isolated from intravenous drug users (IDUs) in Guangxi, China. Phylogenetic analysis of the near full-length genome (NFLG) revealed 2 URFs both clustered with CRF01_AE but setting up a monophyletic branch, supporting a high bootstrap value. Bootscan analysis and subregional recombinant analysis found that the NFLG of 2016GXNNIDU037 and 2019QZLSIDU253 were both composed of CRF01_AE and CRF07_BC, with 3 CRF07_BC mosaic segments inserted into CRF01_AE backbones. The CRF01_AE segments of the 2 URFs clustered with a previously reported cluster 2 lineage of CRF01_AE. The 5 recombinant breakpoints of the 2 URFs were quite similar. Distinct from CRF01_AE/CRF07_BC URFs reported before, 2016GXNNIDU037 and 2019QZLSIDU253 are new evidence of a high genetic variety of HIV-1 in Guangxi, which may pose new challenges to HIV-1 prevention and molecular epidemiological surveillance in China.

1991 ◽  
pp. 132-142 ◽  
Author(s):  
N. Loimer ◽  
O. Presslich ◽  
E. Werner ◽  
G. Pakesch ◽  
E. Hollerer ◽  
...  

Science ◽  
1988 ◽  
Vol 242 (4880) ◽  
pp. 916-919 ◽  
Author(s):  
R. Stoneburner ◽  
D. Des Jarlais ◽  
D. Benezra ◽  
L. Gorelkin ◽  
J. Sotheran ◽  
...  

1989 ◽  
Vol 29 (4) ◽  
pp. 383-383
Author(s):  
DC Des Jarlais ◽  
SR Friedman ◽  
DM Novick ◽  
JL Sotheran ◽  
P Thomas ◽  
...  

HIV Medicine ◽  
2000 ◽  
Vol 1 (3) ◽  
pp. 162-163 ◽  
Author(s):  
S Staszewski ◽  
A Haberl ◽  
A Carlebach ◽  
C Rottmann ◽  
V Miller ◽  
...  

2006 ◽  
Vol 41 (1) ◽  
pp. 100-106 ◽  
Author(s):  
Marco Turci ◽  
Elisabetta Pilotti ◽  
Paola Ronzi ◽  
Giacomo Magnani ◽  
Antonio Boschini ◽  
...  

2000 ◽  
Vol 44 (2) ◽  
pp. 72-78 ◽  
Author(s):  
J.L. Ayuso-Mateos ◽  
M. Pereda ◽  
A. Gómez del Barrio ◽  
S. Echevarria ◽  
M.C. Fariñas ◽  
...  

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