scholarly journals Increased Body Mass Index Is a Risk Factor for Poor Clinical Outcomes after Radical Prostatectomy in Men with International Society of Urological Pathology Grade Group 1 Prostate Cancer Diagnosed with Systematic Biopsies

2021 ◽  
pp. 1-8
Author(s):  
Matteo Ferro ◽  
Daniela Terracciano ◽  
Gennaro Musi ◽  
Ottavio de Cobelli ◽  
Mihai Dorin Vartolomei ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Risk Factor ◽  
Radical Prostatectomy ◽  
Body Mass ◽  
International Society ◽  
Specific Antigen ◽  
Characteristic Analysis ◽  
Grade Group ◽  
Group 1

<b><i>Introduction:</i></b> The association between obesity and clinically significant prostate cancer (PCa) is still a matter of debate. In this study, we evaluated the effect of body mass index (BMI) on the prediction of pathological unfavorable disease (UD), positive surgical margins (PSMs), and biochemical recurrence (BCR) in patients with clinically localized (≤cT2c) International Society of Urological Pathology (ISUP) grade group 1 PCa at biopsy. <b><i>Methods:</i></b> 427 patients with ISUP grade group 1 PCa who have undergone radical prostatectomy and BMI evaluation were included. The outcome of interest was the presence of UD (defined as ISUP grade group ≥3 and pT ≥3a), PSM, and BCR. <b><i>Results:</i></b> Statistically significant differences resulted in comparing BMI with prostate-specific antigen (PSA) and serum testosterone levels (both <i>p</i> &#x3c; 0.0001). Patients with UD and PSM had higher BMI values (<i>p</i> &#x3c; 0.0001 and <i>p</i> = 0.006, respectively). BCR-free survival was significantly decreased in patients with higher BMI values (<i>p</i> &#x3c; 0.0001). BMI was an independent risk factor for BCR and PSM. Receiver-operating characteristic analysis testing PSA accuracy in different BMI groups, showed that PSA had a reduced predictive value (area under the curve [AUC] = 0.535; 95% confidence interval [CI] = 0.422–0.646), in obese men compared to overweight (AUC = 0.664; 95% CI = 0.598–0.725) and normal weight patients (AUC = 0.721; 95% CI = 0.660–0.777). <b><i>Conclusion:</i></b> Our findings show that increased BMI is a significant predictor of UD and PSM at RP in patients with preoperative low-to intermediate-risk diseases, suggesting that BMI evaluation may be useful in a clinical setting to identify patients with favorable preoperative disease characteristics harboring high-risk PCa.

scholarly journals The influence of obesity in patients with prostate cancer - Review of the literature

2013 ◽  
Vol 3 (4) ◽  
pp. 80 ◽  
Author(s):  
Maximilien C. Goris Gbenou
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Risk Factor ◽  
Body Mass ◽  
Functional Foods ◽  
Specific Antigen ◽  
Density Lipoprotein ◽  
Cancer Control ◽  
Sex Hormone Binding Globulin ◽  
Increased Risk

Recent studies have demonstrated an association between higher body mass index and increased aggressiveness in prostate cancer. The present narrative review, based on a search of Medline® and Embase® databases from October 1982 to October 2012, explores the relationship between higher body mass index and localized prostate cancer. In particular, the current epidemiological and mechanistic evidence for interactions between obesity and prostate cancer are discussed. Obesity is associated with alterations in androgen levels, decreased sex hormone binding globulin and increased estrogen levels, insulin resistance, hyperglycemia, alterations in plasma lipoprotein levels particularly raised triglycerides and reduced high density lipoprotein, decreased levels of adiponectin, and increased levels of circulating insulin-growth factor- 1, leptin and dietary saturated fats. Obese men have more aggressive prostate cancer with a greater percentage prostate involvement, increased tumor volume and higher-grade disease, enlarged prostates, high prostate-specific antigen levels, increased risk of having positive margins and recurrence. Moreover, there is strong evidence of the beneficial effects of functional foods for the treatment of obesity. Additionally, an increasing number of studies support that obesity-induced inflammation plays an important role in the development of obesity-related pathologies. Despite, the beneficial role of nutriment in prostate cancer control, the use of functional foods in prostate cancer is not recommended for lack of large epidemiological studies. This data supports the hypothesis that obese men have more aggressive prostate cancers and that the obesity is a modifiable risk factor of prostate cancer. Key Words: prostate cancer, metabolic syndrome, obesity, high BMI, risk factor, diet, functional foods.

Increased body mass index as a risk factor in localized prostate cancer treated by radical prostatectomy

2016 ◽  
Vol 34 (6) ◽  
pp. 254.e1-254.e6 ◽  
Author(s):  
Maximilien C. Goris Gbenou ◽  
Alexandre Peltier ◽  
Claude C. Schulman ◽  
Roland van Velthoven
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Risk Factor ◽  
Radical Prostatectomy ◽  
Body Mass ◽  
Localized Prostate Cancer

scholarly journals Implications of Body Mass Index in Japanese Patients with Prostate Cancer Who Had Undergone Radical Prostatectomy

2010 ◽  
Vol 40 (4) ◽  
pp. 353-359 ◽  
Author(s):  
A. Komaru ◽  
N. Kamiya ◽  
H. Suzuki ◽  
T. Endo ◽  
M. Takano ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Radical Prostatectomy ◽  
Body Mass ◽  
Japanese Patients

scholarly journals Relationship Between Prostate-specific Antigen, Age, and Body Mass Index in a Prostate Cancer Screening Population

2012 ◽  
Vol 35 (5) ◽  
pp. 490-492 ◽  
Author(s):  
Luke E. Pater ◽  
Kimberly W. Hart ◽  
Brian J. Blonigen ◽  
Christopher J. Lindsell ◽  
William L. Barrett
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Cancer Screening ◽  
Prostate Specific Antigen ◽  
Body Mass ◽  
Prostate Cancer Screening ◽  
Specific Antigen ◽  
Screening Population
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