LOW TITER TISSUE TRANSGLUTAMINASE ANTIBODIES: A LINK TO H. PYLORI INFECTION?

2021 ◽  
Author(s):  
BILGE S. AKKELLE ◽  
OZLEM K. SENGUL ◽  
Engin Tutar ◽  
Burcu Volkan ◽  
CIGDEM A. CELIKEL ◽  
...  
Keyword(s):  
Tissue Transglutaminase ◽  
Tissue Transglutaminase Antibodies ◽  
H Pylori

Reliability of anti-tissue transglutaminase antibodies in children with malnutrition

2021 ◽  
Vol 56 (4) ◽  
pp. 378-381
Author(s):  
Necati Balamtekin ◽  
Harun Erdal ◽  
Emira Gençkardeşler ◽  
Melike Arslan
Keyword(s):  
Tissue Transglutaminase ◽  
Tissue Transglutaminase Antibodies

A New Indirect Chemiluminescent Immunoassay to Measure Anti–tissue Transglutaminase Antibodies

2006 ◽  
Vol 43 (5) ◽  
pp. 613-618 ◽  
Author(s):  
Daniela Basso ◽  
Graziella Guariso ◽  
Michela Fasolo ◽  
Marina Pittoni ◽  
Stefania Schiavon ◽  
...  
Keyword(s):  
Tissue Transglutaminase ◽  
Tissue Transglutaminase Antibodies ◽  
Chemiluminescent Immunoassay

scholarly journals Low specificity of anti-tissue transglutaminase antibodies in patients with primary biliary cirrhosis

2006 ◽  
Vol 20 (5) ◽  
pp. 184-189 ◽  
Author(s):  
N. Bizzaro ◽  
M. Tampoia ◽  
D. Villalta ◽  
S. Platzgummer ◽  
M. Liguori ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Tissue Transglutaminase ◽  
Biliary Cirrhosis ◽  
Tissue Transglutaminase Antibodies

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

2018 ◽  
Vol 36 (5) ◽  
pp. 369-376 ◽  
Author(s):  
Nurit Loberman-Nachum ◽  
Michael Schvimer ◽  
Camila Avivi ◽  
Iris Barshack ◽  
Avishay Lahad ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Immunohistochemical Staining ◽  
Clinical Presentation ◽  
Tissue Transglutaminase ◽  
Mucosal Damage ◽  
High Serum ◽  
Tissue Transglutaminase Antibodies ◽  
Antibody Levels ◽  
Age Range ◽  
Multiple Symptoms

Background: The clinical, histological, and serological spectrum of celiac disease (CD) vary widely. We aimed to examine relationships between symptoms, serum anti-tissue transglutaminase antibodies (tTG) levels, mucosal damage, and mucosal anti-tTG deposits in pediatric CD. Methods: A retrospective single-center, cohort study of children referred for endoscopy with suspected CD during 2011–2014. We retrieved the clinical data, blindly reviewed duodenal biopsies, and performed immunohistochemical staining for anti-tTG deposits. Patients were classified as monosymptomatic or polysymptomatic. Mucosal anti-tTG deposits were classified according to the location of deposits, dominant intensity, maximal intensity, and percentage of stained area. Results: Of 252 patients with confirmed CD, complete data were available for 100: 37 males in the age range 1.3–16.7 with median 4.0 years. Monosymptomatic patients (n = 54) presented at an older age than polysymptomatic patients (1.3–15.5, median 8.1 vs. 1.3–16.7, median 6.3 years, p = 0.026). Marsh 2–3c was more prevalent in polysymptomatic patients (93 vs. 78%, p = 0.028). The intensity of mucosal anti-tTG deposits correlated with serum anti-tTG levels but not with the clinical presentation. Conclusions: Multiple symptoms and high serum anti-tTG antibody levels correlated with mucosal damage in children with CD. The role of immunohistochemical staining for intestinal anti-tTG mucosal deposits in the diagnosis of borderline CD is not yet established.

Elevated Serum Tissue Transglutaminase Antibodies in Children With Eosinophilic Esophagitis

2017 ◽  
Vol 65 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Anna K. Le Fevre ◽  
Marjorie M. Walker ◽  
Amir Hadjiashrafy ◽  
Rani Bhatia ◽  
Joerg Mattes ◽  
...  
Keyword(s):  
Eosinophilic Esophagitis ◽  
Tissue Transglutaminase ◽  
Elevated Serum ◽  
Tissue Transglutaminase Antibodies

scholarly journals Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 892 ◽  
Author(s):  
Iva Hoffmanová ◽  
Daniel Sánchez ◽  
Ludmila Tučková ◽  
Helena Tlaskalová-Hogenová
Keyword(s):  
Celiac Disease ◽  
Liver Diseases ◽  
Tissue Transglutaminase ◽  
Intestinal Barrier ◽  
Rational Approach ◽  
Liver Disorders ◽  
Tissue Transglutaminase Antibodies ◽  
Elevated Transaminases ◽  
Made In

Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The objective of the article is to provide a comprehensive and up-to-date review on the latest hypotheses explaining the pathogenetic relationship between celiac disease and liver injury. Besides the involvement of gut–liver axis, tissue transglutaminase antibodies, and impairment of intestinal barrier, we integrate the latest achievements made in elucidation of the role of gut microbiota in celiac disease and liver disorders, that has not yet been sufficiently discussed in the literature in this context. The further objective is to provide a complete clinical overview on the types of liver diseases frequently found in celiac disease. In conclusion, the review highlights the clinical implication, recommend a rational approach for managing elevated transaminases in celiac patients, and underscore the importance of screening for celiac disease in patients with associated liver disease.

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