scholarly journals “Integrating China in the International Consortium for Personalized Medicine”: The Coordination and Support Action to Foster Collaboration in Personalized Medicine Development between Europe and China

2021 ◽  
pp. 1-5
Author(s):  
Alisha Morsella ◽  
Chiara Cadeddu ◽  
Carolina Castagna ◽  
Ilda Hoxhaj ◽  
Michele Sassano ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Dynamic Network ◽  
Healthcare Systems ◽  
Full Potential ◽  
The European Union ◽  
International Consortium ◽  
Horizon 2020 ◽  
Working Groups ◽  
Advance Research ◽  
Effective Translation

“Integrating China in the International Consortium for Personalized Medicine” (IC2PerMed) is a coordination and support action funded within the Horizon 2020 work program. Following the guidance of the International Consortium for Personalized Medicine (ICPerMed), the project’s overarching aim is to align the European Union and China’s research agendas in the field of personalized medicine (PM) to enable a swift development of PM approaches in the EU with strong leverage upon EU-Chinese collaboration. Living in the CO­VID-19 era, we are witnessing how the challenges imposed by the pandemic all around the globe have been acting as a catalyst for collaborations and knowledge sharing among national health systems worldwide. Given the strong interest on behalf of both Europe and China in the advancement of PM approaches, now more than ever, a cross-border collaboration between the 2 powers can accelerate the effective translation of such innovation to healthcare systems, advance research, and ensure that such change follows the directions toward the path of sustainability. IC2PerMed developments will be led by European and Chinese experts equally assembled into 3 Working Groups: (1) people and organization, (2) innovation and market, and (3) research and clinical studies in PM. This complex and dynamic network of actions thrives on dialog, cooperation, and alignment of research at national and global levels; work in the direction taken by IC2PerMed shall pave the way toward the realization of PM’s full potential, prevent it from becoming a burden for healthcare systems, and, rather, prove that it provides an essential and irreplaceable contribution to their effectiveness, efficiency, and sustainability.

scholarly journals Cultural bias in motor function patterns: Potential relevance for predictive, preventive, and personalized medicine

2021 ◽  
Author(s):  
Karen Otte ◽  
Tobias Ellermeyer ◽  
Masahide Suzuki ◽  
Hanna M. Röhling ◽  
Ryota Kuroiwa ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Motor Function ◽  
Motor Performance ◽  
Body Height ◽  
Healthy Adults ◽  
Cultural Bias ◽  
Full Potential ◽  
Japanese Adults ◽  
Body Stature ◽  
Motion Assessment

Abstract Background Quantification of motor performance has a promising role in personalized medicine by diagnosing and monitoring, e.g. neurodegenerative diseases or health problems related to aging. New motion assessment technologies can evolve into patient-centered eHealth applications on a global scale to support personalized healthcare as well as treatment of disease. However, uncertainty remains on the limits of generalizability of such data, which is relevant specifically for preventive or predictive applications, using normative datasets to screen for incipient disease manifestations or indicators of individual risks. Objective This study explored differences between healthy German and Japanese adults in the performance of a short set of six motor tests. Methods Six motor tasks related to gait and balance were recorded with a validated 3D camera system. Twenty-five healthy adults from Chiba, Japan, participated in this study and were matched for age, sex, and BMI to a sample of 25 healthy adults from Berlin, Germany. Recordings used the same technical setup and standard instructions and were supervised by the same experienced operator. Differences in motor performance were analyzed using multiple linear regressions models, adjusted for differences in body stature. Results From 23 presented parameters, five showed group-related differences after adjustment for height and weight (R2 between .19 and .46, p<.05). Japanese adults transitioned faster between sitting and standing and used a smaller range of hand motion. In stepping-in-place, cadence was similar in both groups, but Japanese adults showed higher knee movement amplitudes. Body height was identified as relevant confounder (standardized beta >.5) for performance of short comfortable and maximum speed walks. For results of posturography, regression models did not reveal effects of group or body stature. Conclusions Our results support the existence of a population-specific bias in motor function patterns in young healthy adults. This needs to be considered when motor function is assessed and used for clinical decisions, especially for personalized predictive and preventive medical purposes. The bias affected only the performance of specific items and parameters and is not fully explained by population-specific ethnic differences in body stature. It may be partially explained as cultural bias related to motor habits. Observed effects were small but are expected to be larger in a non-controlled cross-cultural application of motion assessment technologies with relevance for related algorithms that are being developed and used for data processing. In sum, the interpretation of individual data should be related to appropriate population-specific or even better personalized normative values to yield its full potential and avoid misinterpretation.

Monitoring and assessment of an oil spill event with very high resolution tools. 

2021 ◽  
Author(s):  
Ana M. Mancho ◽  
Guillermo García-Sánchez ◽  
Antonio G. Ramos ◽  
Josep Coca ◽  
Begoña Pérez-Gómez ◽  
...  
Keyword(s):  
High Resolution ◽  
Oil Spill ◽  
In Situ Observation ◽  
The European Union ◽  
Horizon 2020 ◽  
Research And Innovation ◽  
Port Authorities ◽  
Different Sources ◽  
Very High

&lt;p&gt;This presentation discusses a downstream application from Copernicus Services, developed in the framework of the IMPRESSIVE project, for the monitoring of &amp;#160;the oil spill produced after the crash of the ferry &amp;#8220;Volcan de Tamasite&amp;#8221; in waters of the Canary Islands on the 21&lt;sup&gt;st&lt;/sup&gt; of April 2017. The presentation summarizes the findings of [1] that describe a complete monitoring of the diesel fuel spill, well-documented by port authorities. Complementary information supplied by different sources enhances the description of the event. We discuss the performance of very high resolution hydrodynamic models in the area of the Port of Gran Canaria and their ability for describing the evolution of this event. Dynamical systems ideas support the comparison of different models performance. Very high resolution remote sensing products and in situ observation validate the description.&lt;/p&gt;&lt;p&gt;Authors acknowledge support from IMPRESSIVE a project funded by the European Union&amp;#8217;s Horizon 2020 research and innovation programme under grant agreement No 821922. SW acknowledges the support of ONR Grant No. N00014-01-1-0769&lt;/p&gt;&lt;p&gt;&lt;strong&gt;References&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;[1] G.Garc&amp;#237;a-S&amp;#225;nchez, A. M. Mancho, A. G. Ramos, J. Coca, B. P&amp;#233;rez-G&amp;#243;mez, E. &amp;#193;lvarez-Fanjul, M. G. Sotillo, M. Garc&amp;#237;a-Le&amp;#243;n, V. J. Garc&amp;#237;a-Garrido, S. Wiggins. Very High Resolution Tools for the Monitoring and Assessment of Environmental Hazards in Coastal Areas. &amp;#160;Front. Mar. Sci. (2021) doi: 10.3389/fmars.2020.605804.&lt;/p&gt;

scholarly journals The Spectrum of Proactive, Resilient Multi-Microgrid Scheduling: A Systematic Literature Review

Energies ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 4543
Author(s):  
Michael Spiegel ◽  
Eric Veith ◽  
Thomas Strasser
Keyword(s):  
Power Systems ◽  
Failure Modes ◽  
Dynamic Network ◽  
Cost Effective ◽  
Great Level ◽  
Full Potential ◽  
Long Run ◽  
Or Groups ◽  
Depth Analysis ◽  
Broad Variety

Multi-microgrids address the need for a resilient, sustainable, and cost-effective electricity supply by providing a coordinated operation of individual networks. Due to local generation, dynamic network topologies, and islanding capabilities of hosted microgrids or groups thereof, various new fault mitigation and optimization options emerge. However, with the great flexibility, new challenges such as complex failure modes that need to be considered for a resilient operation, appear. This work systematically reviews scheduling approaches which significantly influence the feasibility of mitigation options before a failure is encountered. An in-depth analysis of identified key contributions covers aspects such as the mathematical apparatus, failure models and validation to highlight the current methodical spectrum and to identify future perspectives. Despite the common optimization-based framework, a broad variety of scheduling approaches is revealed. However, none of the key contributions provides practical insights beyond lab validation and considerable effort is required until the approaches can show their full potential in practical implementations. It is expected that the great level of detail guides further research in improving and validating existing scheduling concepts as well as it, in the long run, aids engineers to choose the most suitable options regarding increasingly resilient power systems.

scholarly journals Aerial Campaigns for Cal/Val purposes in the Context of Copernicus - Survey Results of the Project “Copernicus Cal/Val Solution (CCVS)”

2021 ◽  
Author(s):  
Stefanie Holzwarth ◽  
Martin Bachmann ◽  
Bringfried Pflug ◽  
Aimé Meygret ◽  
Caroline Bès ◽  
...  
Keyword(s):  
Gap Analysis ◽  
Model Development ◽  
Metrological Traceability ◽  
The European Union ◽  
Horizon 2020 ◽  
Research And Innovation ◽  
Wide Range ◽  
Data Policy ◽  
Survey Results ◽  
Essential Contribution

&lt;p&gt;The objective of the H2020 project &amp;#8220;Copernicus Cal/Val Solution (CCVS)&amp;#8221; is to define a holistic Cal/Val strategy for all ongoing and upcoming Copernicus Sentinel missions. This includes an improved calibration of currently operational or planned Copernicus Sentinel sensors and the validation of Copernicus core products generated by the payload ground segments. CCVS will identify gaps and propose long-term solutions to address currently existing constraints in the Cal/Val domain and exploit existing synergies between the missions. An overview of existing calibration and validation sources and means is needed before starting the gap analysis. In this context, this survey is concerned with measurement capabilities for aerial campaigns.&lt;/p&gt;&lt;p&gt;Since decades airborne observations are an essential contribution to support Earth-System model development and space-based observing programs, both in the domains of Earth Observation (radar and optical) as well as for atmospheric research. The collection of airborne reference data can be directly related to satellite observations, since they are collected in ideal validation conditions using well calibrated reference sensors. Many of these sensors are also used to validate and characterize postlaunch instrument performance. The variety of available aircraft equipped with different instrumentations ranges from motorized gliders to jets acquiring data from different heights to the upper troposphere. In addition, balloons are also used as platforms, either small weather balloons with light payload (around 3 kg), or open stratospheric balloons with big payload (more than a ton). For some time now, UAVs/drones are also used in order to acquire data for Cal/Val purposes. They offer a higher flexibility compared to airplanes, plus covering a bigger area compared to in-situ measurements on ground. On the other hand, they also have limitations when it comes to the weight of instrumentation and maximum altitude level above ground. This reflects the wide range of possible aerial measurements supporting the Cal/Val activities.&lt;/p&gt;&lt;p&gt;The survey will identify the different airborne campaigns. The report will include the description of campaigns, their spatial distribution and extent, ownership and funding, data policy and availability and measurement frequency. Also, a list of common instrumentation, metrological traceability, availability of uncertainty evaluation and quality management will be discussed. The report additionally deals with future possibilities e.g., planned developments and emerging technologies in instrumentation for airborne and balloon based campaigns.&lt;/p&gt;&lt;p&gt;This presentation gives an overview of the preliminary survey results and puts them in context with the Cal/Val requirements of the different Copernicus Sentinel missions.&lt;/p&gt;&lt;p&gt;This project has received funding from the European Union&amp;#8217;s Horizon 2020 research and innovation programme under the grant agreement No 101004242.&lt;/p&gt;

scholarly journals The Influence of the European H2020 Program on the Development of Regions: The Multiplier Impact of EU Funding in the Regions under Horizon 2020 in NUT III - North

2019 ◽  
Vol 17 (3) ◽  
pp. 853-871
Author(s):  
Natacha Jesus Silva ◽  
Diamantino Ribeiro
Keyword(s):  
Regional Economy ◽  
Community Support ◽  
Northern Region ◽  
The European Union ◽  
Final Phase ◽  
Investment Funds ◽  
Horizon 2020 ◽  
Regional Investment ◽  
Partnership Agreement ◽  
The Eu

The partnership agreement between the European Union and the Member States for the implementation of the European Structural and Investment Funds for the period 2014 to 2020 is in its final phase. This study analyzes the multiplier impact on regional investment of the European funds made available to the northern region of Portugal - NUTS III, until September 2018 and intends to answer the following questions: What is the amount invested in the regional economy for each euro of support allocated by the EU through the H2020 program, and what is the percentage distribution of community support versus investment per area of intervention?

scholarly journals Developing a Co-Creative Methodology of Narrative Artwork Production for the BEACONING Platform Metagame.

2020 ◽  
Author(s):  
Jackie Calderwood ◽  
Rachael Till ◽  
Vytautas Vasiliauskas
Keyword(s):  
Comic Book ◽  
The European Union ◽  
Book Art ◽  
Horizon 2020 ◽  
Educational Barriers ◽  
Interactive Narratives ◽  
Learning Platform ◽  
Process Creation ◽  
Gamified Learning ◽  
Media Learning

This paper presents an emergent co-creative methodology for the conception, making and sharing of narrative artwork for a gamified learning platform. Drawing on cinema, the graphic novel, and comic book art, two unusual characters were developed by Student Activators working with researchers at the Disruptive Media Learning Lab, Coventry University. The creative process began by using Clean Language and Clean Space to bring the artists’ character sketches to life, and developed into a series of basic, linear and interactive narratives with original working practices. Extending this collaboration, the paper is co-authored with the two students involved. The authors reflect from their different perspectives on the Collaborative process, creation of narrative artwork and building of a series of metagames for the BEACONING platform ‘Breaking Educational Barriers with Contextualised Pervasive and Gameful Learning’, co-funded by Horizon 2020 programme of the European Union.

Migrants and healthcare within the European Union

2011 ◽  
Vol 1 (1) ◽  
pp. 61-72
Author(s):  
Raluca Nagy
Keyword(s):  
European Union ◽  
Local Population ◽  
Healthcare Systems ◽  
Health Problems ◽  
The European Union ◽  
European Context ◽  
The Relationship ◽  
Migrant Groups

Abstract The investigation of migration can help us understand how the types of migration interact with each other as well as with the various local/national ‘immobilities’. Migrants pose special challenges to healthcare systems, in their origin as well as destination countries. Available data on this topic, following EU interests and policies, focuses on health problems of vulnerable migrant groups, often directed exclusively to issues that can affect the local population. This paper aims to set some explanatory contexts when it comes to the relationship between migration and healthcare within the European context.

Can the health care system be effective? - The research results

2020 ◽  
Vol 3 (14) ◽  
pp. 01-06
Author(s):  
Joanna Jasińska
Keyword(s):  
Health Care ◽  
Personalized Medicine ◽  
Healthcare System ◽  
Health Systems ◽  
Basic Problem ◽  
Economic Value ◽  
Healthcare Systems ◽  
Scientific Databases ◽  
Concepts Of Health

The different definitions of efficiency (in their medical meanings) are presented as the result of meta-reviews found in scientific databases. Efficacy and efficiency are often mismatched with effectiveness in the research of healthcare systems in different countries. In addition to the classic Bismarck’s and Beveridge’s models the modern concepts of health systems include personalized medicine, recognition of health as economic value. However, the basic problem in the Polish healthcare system is the low quality of overly specific and often changed legislation.

Studying new particle formation from chemical emissions from sea surface using  ship-borne air-sea-interaction tanks

2021 ◽  
Author(s):  
Maija Peltola ◽  
Manon Rocco ◽  
Neill Barr ◽  
Erin Dunne ◽  
James Harnwell ◽  
...  
Keyword(s):  
Marine Biology ◽  
Cloud Condensation Nuclei ◽  
Aerosol Particles ◽  
Chemical Species ◽  
Particle Formation ◽  
Biological Properties ◽  
The European Union ◽  
New Particle Formation ◽  
Aerosol Formation ◽  
Horizon 2020

&lt;p&gt;Even though oceans cover over 70% of the Earth&amp;#8217;s surface, the ways in which oceans interact with climate are not fully known. Marine micro-organisms such as phytoplankton can play an important role in regulating climate by releasing different chemical species into air. In air these chemical species can react and form new aerosol particles. If grown to large enough sizes, aerosols can influence climate by acting as cloud condensation nuclei which influence the formation and properties of clouds. Even though a connection of marine biology and climate through aerosol formation was first proposed already over 30 years ago, the processes related to this connection are still uncertain.&lt;/p&gt;&lt;p&gt;To unravel how seawater properties affect aerosol formation and to identify which chemical species are responsible for aerosol formation, we built two Air-Sea-Interaction Tanks (ASIT) that isolate 1000 l of seawater and 1000 l of air directly above the water. The used seawater was collected from different locations during a ship campaign on board the R/V Tangaroa in the South West Pacific Ocean, close to Chatham Rise, east of New Zealand. Seawater from one location was kept in the tanks for 2-3 days and then changed. By using seawater collected from different locations, we could obtain water with different biological populations. To monitor the seawater, we took daily samples to determine its chemical and biological properties.&lt;/p&gt;&lt;p&gt;The air in the tanks was continuously flushed with particle filtered air. This way the air had on average 40 min to interact with the seawater surface before being sampled. Our air sampling was continuous and consisted of aerosol and air chemistry measurements. The instrumentation included measurements of aerosol number concentration from 1 to 500 nm and&amp;#160; chemical species ranging from ozone and sulphur dioxide to volatile organic compounds and chemical composition of molecular clusters.&lt;/p&gt;&lt;p&gt;Joining the seawater and atmospheric data together can give us an idea of what chemical species are emitted from the water into the atmosphere and whether these species can form new aerosol particles. Our preliminary results show a small number of particles in the freshly nucleated size range of 1-3 nm in the ASIT headspaces, indicating that new aerosol particles can form in the ASIT headspaces. In this presentation, we will also explore which chemical species could be responsible for aerosol formation and which plankton groups could be related to the emissions of these species. Combining these results with ambient data and modelling work can shed light on how important new particle formation from marine sources is for climate.&lt;/p&gt;&lt;p&gt;Acknowledgements: Sea2Cloud project is funded by European Research Council (ERC) under the European Union&amp;#8217;s Horizon 2020 research and innovation programme (Grant agreement No. 771369).&lt;/p&gt;

An integrated approach to assess both risk and impacts related with geo-resources exploration and exploitation

2021 ◽  
Author(s):  
Maria Vittoria Gargiulo ◽  
Alexander Garcia ◽  
Ortensia Amoroso ◽  
Paolo Capuano
Keyword(s):  
Life Cycle ◽  
Probabilistic Approach ◽  
Energy Resource ◽  
Clean Energy ◽  
Integrated Approach ◽  
The European Union ◽  
Horizon 2020 ◽  
Risk Sources ◽  
New Perspective

&lt;p&gt;To the welfare of both economy and communities, our society widely exploits geo-resources. Nevertheless, with benefits come risks and even impacts. Understanding how a given project intrinsically bares such risks and impacts is of critical importance for both industry and society. In particular, it is fundamental to distinguish between the specific impacts related to exploiting a given energy resource and those shared with the exploitation of other energy resources. In order to do so, it is useful to differentiate impacts in two categories: routine impacts &amp;#8211; caused by ordinary routine operations, investigated by Life-cycle assessment with a deterministic approach &amp;#8211; and risk impacts &amp;#8211; caused by incidents due to system failure or external events, investigated by risk assessments with a probabilistic approach. The latter category is extremely interesting because it includes low probability/high consequences events, which may not be completely independent or unrelated, causing the most disastrous and unexpected damages. For this reason, it is becoming more and more crucial to develop a strategy to assess not only the single risks but also their possible interaction and to harmonize the result obtained for different risk sources. Of particular interest for this purpose is the Multi-Hazard/Multi-Risk Assessment.&lt;/p&gt;&lt;p&gt;The aim of our work is to present an approach for a comprehensive analysis of impacts of geo-resource development projects. Routine operations as well as risks related to extreme events (as e.g.,seismic or meteorological) are linked using a Multi-Hazard Risk (MHR) approach built upon a Life-Cycle analysis (LCA). Given the complexity of the analysis, it is useful to adopt a multi-level approach: (a) an analysis of routine operations, (b) a qualitative identification of risk scenarios and (c) a quantitative multi-risk analysis performed adopting a bow-tie approach. In particular, after studying the two tools, i.e. LCA and MRA, we have implemented a protocol to interface them and to evaluate certain and potential impacts.&lt;/p&gt;&lt;p&gt;The performance of the proposed approach is illustrated on a virtual site (based on a real one) for geothermal energy production. As a result, we analyse the outcome of the LCA, identify risk-bearing elements and events, to finally obtain harmonised risk matrices for the case study. Such approach, on the one hand, can be used to assess both deterministic and stochastic impacts, on the other hand, can also open new perspective in harmonizing them. Using the LCA outputs as inputs of the MRA can allow the analyst to focus on particular risk pathways that could otherwise seem less relevant but can open new perspective in the risk/impact evaluation of single elements, as we show in this case study.&lt;/p&gt;&lt;p&gt;This work has been supported by S4CE (&quot;Science for Clean Energy&quot;) project, funded from the European Union&amp;#8217;s Horizon 2020 - R&amp;I Framework Programme, under grant agreement No 764810 and by PRIN-MATISSE (20177EPPN2) project funded by Italian Ministry of Education and Research.&lt;/p&gt;

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