White Matter Hyperintensities after Five-Year Follow-Up and a Cross-Sectional FA Decrease in Bipolar I and Major Depressive Patients

2021 ◽  
pp. 1-12
Author(s):  
Tuula Kieseppä ◽  
Riitta Mäntylä ◽  
Katariina Luoma ◽  
Eva Rikandi ◽  
Pekka Jylhä ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Major Depressive ◽  
Cross Sectional ◽  
Clinical Variables ◽  
Brain White Matter ◽  
The Right ◽  
Depressive Patients ◽  
Fractional Anisotrophy

<b><i>Introduction:</i></b> An increase in brain white matter hyperintensities (WMHs) and a decrease in white matter fractional anisotrophy (FA) have been detected in bipolar I (BPI), II (BPII), and major depressive disorder (MDD) patients. Their relationship, and differences in diagnostic groups are obscure. Longitudinal studies are rare. <b><i>Objective:</i></b> After 5-year follow-up, we evaluated WMHs in BPI, BPII, and MDD patients as compared with controls, and studied the effects of clinical variables. We also explored the associations of clinical variables with cross-sectional whole brain FA. <b><i>Methods:</i></b> Eight BPI, 8 BPII, 6 MDD patients, and 19 controls participated in magnetic resonance imaging at baseline and follow-up. Diffusion weighted imaging was included at follow-up. WMHs were rated by the Coffey scale, and a tract-based spatial statistics method was used for diffusion data. The general linear model, ANOVA, Fisher’s exact, Wilcoxon sign, and Kruskal-Wallis tests were used for statistical analyses. <b><i>Results:</i></b> Periventricular WMHs were increased in BPI patients (<i>p</i> = 0.047) and associated with the duration of disorder and lifetime occurrence of substance use disorder (<i>p</i> = 0.018). FA decrease was found in the corpus callosum of BPI patients (<i>p</i> &#x3c; 0.01). MDD patients showed FA decrease in the right cerebellar middle peduncle (RCMP) (<i>p</i> &#x3c; 0.01). In BPI patients, the duration of disorder associated with FA increase in RCMP (<i>p</i> &#x3c; 0.05). No FA decrease was detected in patients with WMHs as compared with those without. <b><i>Conclusions:</i></b> Preceding illness burden associated modestly with WMHs, and FA increase in RCMP in BPI patients. MDD patients had FA decrease in RCMP. No association with FA decrease and WMHs was found.

scholarly journals Brain white-matter hyperintensities and treatment outcome in major depressive disorder

2006 ◽  
Vol 188 (2) ◽  
pp. 180-185 ◽  
Author(s):  
Dan V. Iosifescu ◽  
Perry F. Renshaw ◽  
In Kyoon Lyoo ◽  
Ho Kyu Lee ◽  
Roy H. Perlis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Treatment Outcome ◽  
Cardiovascular Risk ◽  
White Matter ◽  
Depressive Disorder ◽  
Cardiovascular Risk Factors ◽  
White Matter Hyperintensities ◽  
Major Depressive ◽  
Brain White Matter

BackgroundAn increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, but the impact of such hyperintensities on treatment outcome is still controversial.AimsTo investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder.MethodWe assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressanttreatment. We also assessed hyperintensities in 35 matched controls.ResultsWe found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertension and age and with total cardiovascular risk score.ConclusionsSubcortical white-matter hyperintensities in the left hemisphere (but not in other brain areas) may be associated with poor response to antidepressant treatment in major depression.

White matter hyperintensities and cognitive performance in adult patients with bipolar I, bipolar II, and major depressive disorders

2014 ◽  
Vol 29 (4) ◽  
pp. 226-232 ◽  
Author(s):  
T. Kieseppä ◽  
R. Mäntylä ◽  
A. Tuulio-Henriksson ◽  
K. Luoma ◽  
O. Mantere ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Structural Equation Models ◽  
Brain Mri ◽  
Path Model ◽  
Control Group ◽  
Coefficient Estimate ◽  
Major Depressive ◽  
Brain White Matter ◽  
Increased Risk

AbstractPurpose:We evaluate for the first time the associations of brain white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) with neuropsychological variables among middle-aged bipolar I (BPI), II (BPII) and major depressive disorder (MDD) patients and controls using a path model.Methods:Thirteen BPI, 15 BPII, 16 MDD patients, and 21 controls underwent brain MRI and a neuropsychological examination. Two experienced neuroradiologists evaluated WMHs on the MRI scans. We constructed structural equation models to test the strength of the associations between deep WMH (DWMH) grade, neuropsychological performance and diagnostic group.Results:Belonging in the BPI group as opposed to the control group predicted higher DWMH grade (coefficient estimate 1.13, P = 0.012). The DWMH grade independently predicted worse performance on the Visual Span Forward test (coefficient estimate −0.48, P = 0.002). Group effects of BPI and MDD were significant in predicting poorer performance on the Digit Symbol test (coefficient estimate −5.57, P = 0.016 and coefficient estimate −5.66, P = 0.034, respectively).Limitations:Because of the small number of study subjects in groups, the negative results must be considered with caution.Conclusions:Only BPI patients had an increased risk for DWMHs. DWMHs were independently associated with deficits in visual attention.

scholarly journals The Impact of Magnetic Resonance Imaging-Detected White Matter Hyperintensities on Longitudinal Changes in Regional Cerebral Blood Flow

2007 ◽  
Vol 28 (1) ◽  
pp. 190-197 ◽  
Author(s):  
Michael A Kraut ◽  
Lori L Beason-Held ◽  
Wendy D Elkins ◽  
Susan M Resnick
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
White Matter Disease ◽  
Resonance Imaging ◽  
Regional Cerebral Blood ◽  
Longitudinal Changes ◽  
Mri Scans ◽  
The Right ◽  
Over Time

White matter hyperintensities are frequently detected on cranial magnetic resonance imaging (MRI) scans of older adults. Given the presumed ischemic contribution to the etiology of these lesions and the posited import of resting brain activity on cognitive function, we hypothesized that longitudinal changes in MRI-detected white matter disease, and its severity at a given time point, would be associated with changes in regional cerebral blood flow (rCBF) over time. We evaluated MRI scans and resting H215O positron emission tomographic rCBF at baseline and after an average of 7.7-year follow-up in Baltimore Longitudinal Study of Aging participants without dementia. Differences in patterns of rCBF were evident at baseline and at follow-up between the group of subjects showing increased white matter disease over the 8-year interval compared with the group with stable white matter ratings. Furthermore, longitudinal changes over time in rCBF also differed between the two groups. Specifically, the group with progressive white matter abnormalities showed greater increase in the right inferior temporal gyrus/fusiform gyrus, right anterior cingulate, and the rostral aspect of the left superior temporal gyrus. Regions of greater longitudinal decrease in this group were evident in the right inferior parietal lobule and at the right occipital pole. Changes in white matter disease over time and its severity at any given time are associated significantly with both cross-sectional and longitudinal patterns of rCBF. The longitudinal increases may reflect cortical compensation mechanisms for reduced efficacy of interregional neural communications that result from white matter deterioration.

scholarly journals Microstructural white matter changes preceding white matter hyperintensities in migraine

Neurology ◽  
2019 ◽  
Vol 93 (7) ◽  
pp. e688-e694 ◽  
Author(s):  
Enrico B. Arkink ◽  
Inge H. Palm-Meinders ◽  
Hille Koppen ◽  
Julien Milles ◽  
Baldur van Lew ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
White Matter Changes ◽  
Whole Brain ◽  
Microstructural Changes ◽  
Tissue Integrity ◽  
Brain White Matter

ObjectiveWe used magnetization transfer imaging to assess white matter tissue integrity in migraine, to explore whether white matter microstructure was more diffusely affected beyond visible white matter hyperintensities (WMHs), and to explore whether focal invisible microstructural changes precede visible focal WMHs in migraineurs.MethodsWe included 137 migraineurs (79 with aura, 58 without aura) and 74 controls from the Cerebral Abnormalities in Migraine, an Epidemiological Risk Analysis (CAMERA) study, a longitudinal population-based study on structural brain lesions in migraine patients, who were scanned at baseline and at a 9-year follow-up. To assess microstructural brain tissue integrity, baseline magnetization transfer ratio (MTR) values were calculated for whole brain white matter. Baseline MTR values were determined for areas of normal-appearing white matter (NAWM) that had progressed into MRI-detectable WMHs at follow-up and compared to MTR values of contralateral NAWM.ResultsMTR values for whole brain white matter did not differ between migraineurs and controls. In migraineurs, but not in controls, NAWM that later progressed to WMHs at follow-up had lower mean MTR (mean [SD] 0.354 [0.009] vs 0.356 [0.008], p = 0.047) at baseline as compared to contralateral white matter.ConclusionsWe did not find evidence for widespread microstructural white matter changes in migraineurs compared to controls. However, our findings suggest that a gradual or stepwise process might be responsible for evolution of focal invisible microstructural changes into focal migraine-related visible WMHs.

scholarly journals QOL-09. WHOLE-BRAIN WHITE MATTER NETWORK CONNECTIVITY IS DISRUPTED BY PEDIATRIC BRAIN TUMOR TREATMENT

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii432-iii432
Author(s):  
Adeoye Oyefiade ◽  
Kiran Beera ◽  
Iska Moxon-Emre ◽  
Jovanka Skocic ◽  
Ute Bartels ◽  
...  
Keyword(s):  
White Matter ◽  
Pediatric Brain Tumor ◽  
Pediatric Brain Tumors ◽  
Magnetic Resonance Images ◽  
Long Term Effects ◽  
Brain White Matter ◽  
The Right ◽  
Pediatric Brain ◽  
Betweeness Centrality

Abstract INTRODUCTION Treatments for pediatric brain tumors (PBT) are neurotoxic and lead to long-term deficits that are driven by the perturbation of underlying white matter (WM). It is unclear if and how treatment may impair WM connectivity across the entire brain. METHODS Magnetic resonance images from 41 PBT survivors (mean age: 13.19 years, 53% M) and 41 typically developing (TD) children (mean age: 13.32 years, 51% M) were analyzed. Image reconstruction, segmentation, and node parcellation were completed in FreeSurfer. DTI maps and probabilistic streamline generation were completed in MRtrix3. Connectivity matrices were based on the number of streamlines connecting two nodes and the mean DTI (FA) index across streamlines. We used graph theoretical analyses to define structural differences between groups, and random forest (RF) analyses to identify hubs that reliably classify PBT and TD children. RESULTS For survivors treated with radiation, betweeness centrality was greater in the left insular (p &lt; 0.000) but smaller in the right pallidum (p &lt; 0.05). For survivors treated without radiation (surgery-only), betweeness centrality was smaller in the right interparietal sulcus (p &lt; 0.05). RF analyses showed that differences in WM connectivity from the right pallidum to other parts of the brain reliably classified PBT survivors from TD children (classification accuracy = 77%). CONCLUSIONS The left insular, right pallidum, and right inter-parietal sulcus are structurally perturbed hubs in PBT survivors. WM connectivity from the right pallidum is vulnerable to the long-term effects of treatment for PBT.

Major Depressive Disorder With Anger Attacks and Subcortical MRI White Matter Hyperintensities

2007 ◽  
Vol 195 (2) ◽  
pp. 175-178 ◽  
Author(s):  
Dan V. Iosifescu ◽  
Perry F. Renshaw ◽  
Darin D. Dougherty ◽  
In Kyoon Lyoo ◽  
Ho Kyu Lee ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
White Matter Hyperintensities ◽  
Major Depressive ◽  
Anger Attacks

Clinical Significance of Brain White Matter Hyperintensities in Young Adults with Psychiatric Illness

2003 ◽  
Vol 11 (5) ◽  
pp. 269-283 ◽  
Author(s):  
Janis L. Breeze ◽  
Dale C. Hesdorffer ◽  
Xiaoni Hong ◽  
Jean A. Frazier ◽  
Perry F. Renshaw
Keyword(s):  
Young Adults ◽  
White Matter ◽  
Clinical Significance ◽  
Psychiatric Illness ◽  
White Matter Hyperintensities ◽  
Brain White Matter

Characteristics of carotid atherosclerosis and brain white matter hyperintensities in asymptomatic patients with intermediate stenosis

2017 ◽  
Vol 263 ◽  
pp. e57
Author(s):  
Francesco Moroni ◽  
Enrico Ammirati ◽  
Marco Magnoni ◽  
Maria Assunta Rocca ◽  
Roberta Messina ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Carotid Atherosclerosis ◽  
Brain White Matter ◽  
Asymptomatic Patients

Longitudinal Association between White Matter Hyperintensities and White Matter Beta-Amyloid Deposition in Cognitively Unimpaired Elderly

2021 ◽  
Vol 18 ◽  
Author(s):  
Ming-Liang Wang ◽  
Meng-Meng Yu ◽  
Wen-Bin Li ◽  
Yue-Hua Li
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Beta Amyloid ◽  
Standard Uptake Value ◽  
Amyloid Deposition ◽  
Cognitive Measures ◽  
Cross Sectional ◽  
Memory Decline ◽  
Annual Increase ◽  
Longitudinal Association

Background: White matter (WM) beta-amyloid uptake has been used as a reference region to calculate the cortical standard uptake value ratio (SUVr). However, white matter hyperintensities (WMH) may have an influence on WM beta-amyloid uptake. Our study aimed to investigate the associations between WMH and WM beta-amyloid deposition in cognitively unimpaired elderly. Method: Data from 83 cognitively unimpaired individuals in the Alzheimer’s Disease Neuroimag- ing Initiative (ADNI) dataset were analyzed. All participants had complete baseline and four-year follow-up information about WMH volume, WM 18F-AV-45 SUVr, and cognitive function, includ- ing ADNI-Memory (ADNI-Mem) and ADNI-Executive function (ADNI-EF) scores. Cross-sectional and longitudinal linear regression analyses were used to determine the associations between WMH and WM SUVr and cognitive measures. Results: Lower WM 18F-AV-45 SUVr at baseline was associated with younger age (β=0.01, P=0.037) and larger WMH volume (β=-0.049, P=0.048). The longitudinal analysis found an annual increase in WM 18F-AV-45 SUVr was associated with an annual decrease in WMH volume (β=-0.016, P=0.041). An annual decrease in the ADNI-Mem score was associated with an annual increase in WMH volume (β=-0.070, P=0.001), an annual decrease in WM 18F-AV-45 SUVr (β=0.559, P=0.030), and fewer years of education (β=0.011, P=0.044). There was no significant as- sociation between WM 18F-AV-45 SUVr and ADNI-EF (P>0.05). Conclusions: Reduced beta-amyloid deposition in WM was associated with higher WMH load and memory decline in cognitively unimpaired elderly. WMH volume should be considered when WM 18F-AV-45 SUVr is used as a reference for evaluating cortical 18F-AV-45 SUVr.

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