A refinement of clinical tumour marker monitoring - why not use an inverse value of doubling time?
The aim of this study was to compare prostate specific antigen (PSA) kinetics – half life time (HT), doubling time (DT) and elimination rate PSA (ePSA) in prostate cancer monitoring. We report that implementation of inverse value (ePSA) rather than HT or DT has distinct advantages: (1) values are valid when PSA is unchanged (ePSA equals zero), (2) the concept of ePSA is easily comprehendible – it is a growth fraction, (3) ePSA fluctuates in a narrow range – easy to interpret, no large numbers, (4) no mathematical flaws (no positive skewing). Exploring ePSA norm as < 0% might help to timely spot a biochemical recurrence (BCR). Primary health care providers (PHCP) tend to habitually use an irrelevant PSA threshold – 4.0 ng/ml in postoperative follow-up. The delayed referrals of patients in remission might be reduced if PHCPs adopt an ePSA.