Clinical and Radiological Follow-Up Results of Patients with Sequestered Lumbar Disc Herniation: A Prospective Cohort Study
Purpose: To assess radiological changes and clinical outcomes of patients with sequestered lumbar disc herniation (LDH) and evaluate the relationship between them. Methods: Patients diagnosed with sequestered LDH were followed-up in two groups: operated (within the first month after diagnosis) and nonoperated. Visual analog scale (VAS) and Oswestry Disability Index (ODI) scores at baseline (V1) and 1st (V2), 3rd (V3), 6th (V4) month visits were used for clinical evaluation. Radiological evaluation was performed by measuring the sequestered LDH level and herniation volume using magnetic resonance imaging (MRI) at V1 and V4. After the second MRI, patients in the nonoperated group were divided into three groups: nonregression (n=6), partial regression (n=22), and complete resolution (n=27); patients were analyzed in four groups including the ones in the operated (n=25) group. Results: Significant improvements were observed in VAS and ODI scores at V2 and V3 in all groups and at V4 in partial regression and complete resolution groups. VAS and ODI score improvements at V2 and V3 were significantly higher in the operated group than in other groups. At V4, no significant difference remained between the operated group and partial regression and complete resolution groups regarding VAS and ODI scores. Conclusions: Spontaneous regression was observed in the 6th month MRI in most of the nonoperated sequestered LDH patients with conservative treatment. Improvements in pain and disability scores were higher among the operated patients at the early stage, whereas they were found to have no difference with spontaneous regression patients at the 6th month.