scholarly journals Cellular Signaling Mechanisms of Hypocretin/Orexin

2021 ◽  
pp. 91-102
Author(s):  
Jyrki P. Kukkonen ◽  
Pauli M. Turunen
Keyword(s):  
Cellular Signaling ◽  
Signaling Mechanisms

Thrombin-induced vasospasm: Cellular signaling mechanisms

Surgery ◽  
1998 ◽  
Vol 123 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Hilde Jerius ◽  
Arthur Beall ◽  
David Woodrum ◽  
Aaron Epstein ◽  
Colleen Brophy
Keyword(s):  
Cellular Signaling ◽  
Signaling Mechanisms

scholarly journals Cytokinin Sensing in Bacteria

Biomolecules ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 186
Author(s):  
Samar Kabbara ◽  
Baptiste Bidon ◽  
Jaafar Kilani ◽  
Marwan Osman ◽  
Monzer Hamze ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Host Plant ◽  
Plant Hormones ◽  
Cellular Signaling ◽  
Phytopathogenic Bacteria ◽  
Signaling Mechanisms ◽  
Plant Chemicals ◽  
First Time ◽  
Broad Role

Although it has long been known that bacteria detect and react to plant chemicals to establish an interaction, the cellular signaling mechanisms involved in these perception processes have hitherto remained obscure. Some exciting recent advances in the field have described, for the first time, how some phytopathogenic bacteria sense the host plant hormones, cytokinins. These discoveries not only advance the understanding of cell signaling circuitries engaged in cytokinin sensing in non-plant organisms, but also increase our knowledge of the broad role of these ancient molecules in regulating intra- and interspecific communications.

scholarly journals Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Alexandra M. Thomas ◽  
Ronald S. Duman
Keyword(s):  
Nmda Receptor ◽  
Signaling Pathways ◽  
Neural Circuits ◽  
Cellular Signaling ◽  
Treatment Options ◽  
Time Lag ◽  
Current Understanding ◽  
Signaling Mechanisms ◽  
Research Techniques ◽  
The Brain

Depression is a chronic, debilitating, and common illness. Currently available pharmacotherapies can be helpful but have several major drawbacks, including substantial rates of low or no response and a long therapeutic time lag. In pursuit of better treatment options, recent research has focussed on rapid-acting antidepressants, including the N-methyl-d-aspartate (NMDA) receptor (NMDAR) antagonist ketamine, which affects a range of signaling pathways in ways that are distinct from the mechanisms of typical antidepressants. Because ketamine and similar drugs hold the promise of dramatically improving treatment options for depressed patients, there has been considerable interest in developing new ways to understand how these compounds affect the brain. Here, we review the current understanding of how rapid-acting antidepressants function, including their effects on neuronal signaling pathways and neural circuits, and the research techniques being used to address these questions.

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