scholarly journals NASH/liver fibrosis prevalence and incidence of non-liver comorbidities among people with NAFLD and incidence of NAFLD by metabolic comorbidites: Lessons from South Korea

2021 ◽  
Author(s):  
Jiyoon Park ◽  
Eunice Yewon Lee ◽  
Jie Li ◽  
Mi Jung Jun ◽  
Eileen Yoon ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Disease Incidence ◽  
Cochrane Library ◽  
Outcome Analysis ◽  
Mortality Data ◽  
All Cause Mortality ◽  
Incidence Analysis ◽  
Cardiovascular Disease Incidence ◽  
Metabolic Comorbidities ◽  
New Onset

Background: NAFLD incidence, NASH prevalence, NAFLD fibrosis prevalence, incidence of metabolic comorbidities, as well as mortality data in the NAFLD population remain limited. Aims: We used a meta-analytic approach to “stage” NAFLD among the Korean population. Methods: We searched PubMed, Embase, Cochrane Library, and KoreaMed from inception until June 29, 2019 and calculated pooled estimates via random-effects model. Results: We screened 1,485 studies and analyzed 191 eligible studies: 179 (3,556,579 participants) for NAFLD prevalence and outcome analysis and 32 (1,089,785 participants) for NAFLD incidence analysis. NAFLD prevalence was 31.46% overall and 50-60% in those with metabolic risks. The incidence (per 1,000 person-years) of NAFLD was 42.8 overall and 70-77% in those with metabolic risk. The incidence (per 1,000 person-years) of new onset T2DM, hypertension, cardiovascular disease, and chronic kidney disease were found to be 16.9, 47.9, 100.6, and 13.9, respectively. From biopsy data, 30.21% of the NAFLD population had moderate-to-severe steatosis (9 studies, 2,461 participants) and 52.27% had NASH (7 studies, 1,168 participants); 85.41% had fibrosis < stage 2 (8 studies, 1,995 participants). All-cause mortality was 2.6 (1.3 if without malignancy) per 1,000 person-years. Conclusions: The overall prevalence of NAFLD was 31.46% with an incidence rate of 42.8 per 1000 person-years. NASH prevalence was 52% but <15% had significant fibrosis. The prevalence and incidence of non-liver comorbidities was high especially for cardiovascular disease incidence. The burden of NAFLD is high in Korea. Health policy efforts need to be directed towards reversing the course of NAFLD disease.

Ten-year (2002–2012) cardiovascular disease incidence and all-cause mortality, in urban Greek population: The ATTICA Study

2015 ◽  
Vol 180 ◽  
pp. 178-184 ◽  
Author(s):  
Demosthenes B. Panagiotakos ◽  
Ekavi N. Georgousopoulou ◽  
Christos Pitsavos ◽  
Christina Chrysohoou ◽  
Vassiliki Metaxa ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Disease Incidence ◽  
Greek Population ◽  
All Cause Mortality ◽  
Cardiovascular Disease Incidence

Semiparametric regression of the illness-death model with interval censored disease incidence time: An application to the ACLS data

2020 ◽  
Vol 29 (12) ◽  
pp. 3707-3720
Author(s):  
Jie Zhou ◽  
Jiajia Zhang ◽  
Alexander C McLain ◽  
Wenbin Lu ◽  
Xuemei Sui ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Longitudinal Study ◽  
Disease Incidence ◽  
Semiparametric Regression ◽  
Interval Censoring ◽  
Right Censored Data ◽  
Model Account ◽  
All Cause Mortality ◽  
Cardiovascular Disease Incidence ◽  
Aerobics Center Longitudinal Study

To investigate the effect of fitness on cardiovascular disease and all-cause mortality using the Aerobics Center Longitudinal Study, we develop a semiparametric illness-death model account for intermittent observations of the cardiovascular disease incidence time and the right censored data of all-cause mortality. The main challenge in estimation is to handle the intermittent observations (interval censoring) of cardiovascular disease incidence time and we develop a semiparametric estimation method based on the expectation-maximization algorithm for a Markov illness-death regression model. The variance of the parameters is estimated using profile likelihood methods. The proposed method is evaluated using extensive simulation studies and illustrated with an application to the Aerobics Center Longitudinal Study data.

scholarly journals Physical activity attenuates cardiovascular risk and mortality in men and women with and without the metabolic syndrome – a 20-year follow-up of a population-based cohort of 60-year-olds

2020 ◽  
pp. 204748732091659
Author(s):  
Elin Ekblom-Bak ◽  
Mats Halldin ◽  
Max Vikström ◽  
Andreas Stenling ◽  
Bruna Gigante ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Disease Incidence ◽  
Population Based ◽  
Men And Women ◽  
All Cause Mortality ◽  
Old Men ◽  
Cardiovascular Disease Incidence

Aims The purpose of this study was to analyse the association of leisure-time physical activity of different intensities at baseline, and cardiovascular disease incidence, cardiovascular disease mortality and all-cause mortality in a population-based sample of 60-year-old men and women with and without established metabolic syndrome, for more than 20 years of follow-up. A secondary aim was to study which cardiometabolic factors may mediate the association between physical activity and long-term outcomes. Methods A total of 3693 participants (53% women) underwent physical examination and laboratory tests, completed an extensive questionnaire at baseline 1997–1999 and were followed until their death or until 31 December 2017. First-time cardiovascular disease events and death from any cause were ascertained through regular examinations of national registers. Results Metabolic syndrome prevalence was 23.0%. In metabolic syndrome participants, light physical activity attenuated cardiovascular disease incidence (hazard ratio = 0.71; 95% confidence interval 0.50–1.00) compared to sedentary (reference) after multi-adjustment. Moderate/high physical activity was inversely associated with both cardiovascular disease and all-cause mortality, but became non-significant after multi-adjustment. Sedentary non-metabolic syndrome participants had lower cardiovascular disease incidence (0.47; 0.31–0.72) but not significantly different cardiovascular disease (0.61; 0.31–1.19) and all-cause mortality (0.92; 0.64–1.34) compared to sedentary metabolic syndrome participants. Both light and moderate/high physical activity were inversely associated with cardiovascular disease and all-cause mortality in non-metabolic syndrome participants ( p<0.05). There were significant variations in several central cardiometabolic risk factors with physical activity level in non-metabolic syndrome participants. Fibrinogen mediated the protective effects of physical activity in non-metabolic syndrome participants. Conclusion Physical activity of different intensities attenuated cardiovascular risk and mortality in 60-year old men and women with metabolic syndrome during a 20-year follow-up.

scholarly journals Global Trend in Overweight and Obesity and Its Association With Cardiovascular Disease Incidence

2014 ◽  
Vol 78 (12) ◽  
pp. 2807-2818 ◽  
Author(s):  
Hiroshi Yatsuya ◽  
Yuanying Li ◽  
Esayas Haregot Hilawe ◽  
Atsuhiko Ota ◽  
Chaochen Wang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Disease Incidence ◽  
Overweight And Obesity ◽  
Global Trend ◽  
Cardiovascular Disease Incidence
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