scholarly journals Unilateral Nevoid Telangiectasia in a Healthy Man

2021 ◽  
pp. 330-335
Author(s):  
Kirley Küçük ◽  
Florence Bourlond ◽  
Nicolas Votquenne ◽  
Farida Benhadou
Keyword(s):  
Blood Test ◽  
Atrial Myxoma ◽  
Upper Extremities ◽  
Thyroid Disorder ◽  
Underlying Condition ◽  
The Third ◽  
Diagnostic Hypothesis ◽  
Rare Diagnosis ◽  
Thyroid Dysfunctions ◽  
Rule Out

We report the case of a healthy 26-year-old man presenting telangiectatic macules on the left thorax and arm since childhood. The main diagnostic hypothesis were unilateral nevoid telangiectasia (UNT), hereditary benign telangiectasia, atrial myxoma, segmental serpiginous angioma, circumscribed neviform angiokeratoma, and nevus vascularis mixtus. The diagnosis retained was UNT characterized by congenital or acquired telangiectasia distributed asymmetrically along the upper extremities, or the third or fourth cervical dermatomes. The congenital form is extremely rare, predominant in men, and persists in adulthood. The acquired form is most frequent, affects preferentially women, usually appears at puberty or during pregnancy and tends to disappear. Estrogen excess triggers the formation of telangiectasia. UNT is rarely associated with liver or thyroid disorder. Pulsed-dye lasers and normalization of estrogen are proposed as therapeutic options. We report a rare diagnosis of UNT in a young man with no other underlying condition. We would like to highlight that in the presence of unilateral telangiectasia, a complete clinical examination must be performed to rule out signs of hyperestrogenism in man, ocular or neurological abnormalities, a blood test to exclude pregnancy, hepatic and thyroid dysfunctions, and ultrasonography in case of suspicion of atrial myxoma.

DIAGNOSIS TIROID

2016 ◽  
Vol 21 (3) ◽  
pp. 304
Author(s):  
Liong Boy Kurniawan ◽  
Mansyur Arif
Keyword(s):  
Thyroid Hormone ◽  
Laboratory Tests ◽  
Thyroid Disorder ◽  
Functional Tests ◽  
Hormone Binding ◽  
Functional Diagnosis ◽  
Underlying Condition ◽  
Unusual Combination ◽  
The Right ◽  
Underlying Diseases

Thyroid disease often causes unspecific or mild symptoms, so laboratory tests are needed to confirm the functional diagnosis of the thyroid disorder. The laboratory tests which are important to establish the diagnosis of thyroid disorder include: total and free thyroidhormones, its related (thyroid) hormone binding proteins and auto antibodies. The thyroid hormone tests are mostly measured with competitive or sandwich immunoassays and each method can be interfered by several factors. Some drugs may increase or decrease thethyroid functional tests and several factors such as: underlying diseases, age, pregnancy, occurrence of heterophil antibody and auto antibodies may also interfere the thyroid tests results. The interpretation of an unusual combination from thyroid stimulating hormonesuch as free thyroxin and tri-iodothyronine results needs confirmation of underlying condition for establishing the right diagnosis. This review is aimed to evaluate several factors which may influence the thyroid tests and interpretation.

scholarly journals Jaws of a large belemnite and an ammonite from the Aalenian (Middle Jurassic) of Switzerland

2020 ◽  
Vol 139 (1) ◽  
Author(s):  
Christian Klug ◽  
Walter Etter ◽  
René Hoffmann ◽  
Dirk Fuchs ◽  
Kenneth De Baets
Keyword(s):  
Middle Jurassic ◽  
Opalinus Clay ◽  
Northern Switzerland ◽  
The Third ◽  
Large Size ◽  
Upper Jaw ◽  
Rule Out

AbstractAlthough belemnite rostra can be quite abundant in Jurassic and Cretaceous strata, the record of belemnite jaws was limited to a few specimens from Germany and Russia. Here, we describe and figure three cephalopod jaws from the Middle Jurassic Opalinus Clay of northern Switzerland. Although flattened, the carbonaceous fossils display enough morphological information to rule out an ammonoid, nautiloid or octobrachian origin of the two larger jaws. Their similarities to belemnite jaws from Germany and Russia conforms with our interpretation of these specimens as belemnite jaws. Based on their rather large size, we tentatively assign these two jaws to the megateuthidid Acrocoelites conoideus. The third jaw is a rather small upper jaw of an ammonoid. Since Leioceras opalinum is by far the most common ammonite in this unit in northern Switzerland, we tentatively suggest that the upper jaw belongs to this species.

scholarly journals An Augmented Model with Inferred Blood Features for the Self-diagnosis of Metabolic Syndrome

2020 ◽  
Vol 59 (01) ◽  
pp. 018-030
Author(s):  
Tianshu Zhou ◽  
Ying Zhang ◽  
Chengkai Wu ◽  
Chao Shen ◽  
Jingsong Li ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Test Data ◽  
Classification Accuracy ◽  
Blood Test ◽  
Health Management ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Developed Countries ◽  
The Third ◽  
Health Checks

Abstract Background and Objectives The penetration rate of physical examinations in China is substantially lower than that in developed countries. Therefore, an auxiliary approach that does not depend on hospital health checks for the diagnosis of metabolic syndrome (MetS) is needed. Methods In this study, we proposed an augmented method with inferred blood features that uses self-care inputs available at home for the auxiliary diagnosis of MetS. The dataset used for modeling contained data on 91,420 individuals who had at least 2 consecutive years of health checks. We trained three separate models using a regularized gradient-boosted decision tree. The first model used only home-based features; additional blood test data (including triglyceride [TG] data, fasting blood glucose data, and high-density lipoprotein cholesterol [HDL-C] data) were included in the second model. However, in the augmented approach, the blood test data were manipulated using multivariate imputation by chained equations prior to inclusion in the third model. The performance of the three models for MetS auxiliary diagnosis was then quantitatively compared. Results The results showed that the third model exhibited the highest classification accuracy for MetS in comparison with the other two models (area under the curve [AUC]: 3rd vs. 2nd vs. 1st = 0.971 vs. 0.950 vs. 0.905, p < 0.001). We further revealed that with full sets of the three measurements from earlier blood test data, the classification accuracy of MetS can be further improved (AUC: without vs. with = 0.971 vs. 0.993). However, the magnitude of improvement was not statistically significant at the 1% level of significance (p = 0.014). Conclusion Our findings demonstrate the feasibility of the third model for MetS homecare applications and lend novel insights into innovative research on the health management of MetS. Further validation and implementation of our proposed model might improve quality of life and ultimately benefit the general population.

scholarly journals Attenuation of lipopolysaccharide anorexia by antagonism of caudal brain stem but not forebrain GLP-1-R

2004 ◽  
Vol 287 (5) ◽  
pp. R1190-R1193 ◽  
Author(s):  
Harvey J. Grill ◽  
Jill S. Carmody ◽  
L. Amanda Sadacca ◽  
Diana L. Williams ◽  
Joel M. Kaplan
Keyword(s):  
Food Intake ◽  
Brain Stem ◽  
Third Ventricle ◽  
Cerebral Aqueduct ◽  
Relative Importance ◽  
The Third ◽  
Native Peptide ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Rule Out

The central glucagon-like peptide-1 (GLP-1) system has been implicated in the control of feeding behavior. Here we explore GLP-1 mediation of the anorexic response to administration of systemic LPS and address the relative importance of caudal brain stem and forebrain GLP-1 receptor (GLP-1-R) for the mediation of the response. Fourth-intracerebroventricular delivery of the GLP-1-R antagonist exendin-(9–39) (10 μg) did not itself affect food intake in the 24 h after injection but significantly attenuated the otherwise robust (∼60%) reduction in food intake obtained after LPS (100 μg/kg) treatment. This result highlights a role for caudal brain stem GLP-1-R in the mediation of LPS anorexia but does not rule out the possibility that forebrain receptors also contribute to the response. Forebrain contribution was addressed by delivery of the GLP-1-R antagonist to the third ventricle with the caudal flow of cerebrospinal fluid blocked by occlusion of the cerebral aqueduct. Exendin-(9–39) delivery thus limited to forebrain did not attenuate the anorexic response to LPS. These data suggest that LPS anorexia is mediated, in part, by release of the native peptide acting on GLP-1-R within the caudal brain stem.

scholarly journals D-Dimer Concentrations in Normal Pregnancy: New Diagnostic Thresholds Are Needed

2005 ◽  
Vol 51 (5) ◽  
pp. 825-829 ◽  
Author(s):  
Jeffrey A Kline ◽  
Ginger W Williams ◽  
Jackeline Hernandez-Nino
Keyword(s):  
Fetal Loss ◽  
Pregnant Patient ◽  
Normal Pregnancy ◽  
Progressive Increase ◽  
Third Trimester ◽  
The Third ◽  
Diagnostic Thresholds ◽  
Turbidimetric Assay ◽  
D Dimer ◽  
Rule Out

Abstract Background: Pregnancy is known to increase the D-dimer concentration above the conventional normal threshold of 0.50 mg/L, leading to an increased false-positive D-dimer test when venous thromboembolism (VTE) is clinically suspected in a pregnant patient. Our aim was to determine the effect of normal pregnancy on the D-dimer concentration. Methods: Healthy women who were seeking to become pregnant and had no preexisting condition known to increase the D-dimer concentration were identified. Quantitative D-dimer measurements (MDA turbidimetric assay) and fibrinogen assays were performed before conception, at each trimester, and at 4 weeks postpartum. Patients were excluded for fetal loss or preeclampsia. Results: A total of 50 women were enrolled in the study, and blood samples were obtained at preconception and all trimesters from 23 women. The mean (SD) preconception D-dimer concentration was 0.43 (0.49) mg/L, and 79% of women had a D-dimer concentration &lt;0.50 mg/L. D-Dimer increased with each trimester such that only 22% of women in the second trimester and none (of 23) in the third trimester (95% confidence interval, 0–14%) had a D-dimer concentration &lt;0.50 mg/L. We found no correlation between either the D-dimer and fibrinogen concentrations or between the increases in D-dimer and fibrinogen with pregnancy. Conclusions: Normal pregnancy causes a progressive increase in circulating D-dimer. The D-dimer test has no use in ruling out VTE in the third trimester if a cutoff of 0.50 mg/L is used. A large management study is needed to establish new thresholds for the D-dimer to rule out VTE in each trimester.

scholarly journals The Effect of Grazing on the Production of Sows and Pasture Vegetation

2004 ◽  
pp. 43-47
Author(s):  
Róbert Szendi ◽  
Imre Bodó ◽  
Géza Nagy
Keyword(s):  
Blood Serum ◽  
Blood Test ◽  
Beta Carotene ◽  
Control Group ◽  
The Third ◽  
The Poor ◽  
And Control

In our experiment sows were grased during four grazing seasons, from April 28, 2000 to 23, August, 2001. The same number of indoor sows served as control animals.The results of the blood test show that, as a result of grazing, the beta carotene level of the blood serum has increased threefold. This difference disappeard after the farrow 30 days.On spring pasture, the grasingsows gained 50 kg in weight as opposed to 30 kg in the control animals. On the poor autumn pasture, the weight gained was only 30 kg, which was only 2 kg more in comparison with the performance of the control group. In the third grasing season the experiment sows weight gained was 13.7 kg and control group 37 kg. In the fourth season the control group weight gained was 4.4 kg more in comparison with the performance of the experiment sows.Grazing not very influence weight of gthe sows during the preast – feeding.

On General Paralysis

1861 ◽  
Vol 7 (38) ◽  
pp. 278-285
Author(s):  
Harrington Tuke
Keyword(s):  
Physical Symptoms ◽  
Upper Extremities ◽  
Considerable Time ◽  
General Paralysis ◽  
Second Stage ◽  
The Third ◽  
Organic Life ◽  
Careful Treatment ◽  
Convulsive Seizures

The physical symptoms attending the general paralysis of the insane have been shown to present in their progress three well-defined stages. Some of the earliest physical signs—any one of which associated with a particular form of insanity will almost infallibly indicate the first stage of this special disorder—are the intermittent pulse, the irregular or contracted pupil, the quivering lip or embarrassed articulation. The second stage is marked by loss of power in the upper extremities, by a gait more or less unsteady, by diminished sensation in the cutaneous nerves, or by the loss of some of the special senses. In the third period the disease approaches its climax, in an entire want of motory power, and by an impairment of all the nervous functions so universal, that although organic life may, under careful treatment, be prolonged for a considerable time, the patient may be said to exist rather than to live. Epileptiform attacks may precede or accompany any one of these stages. They sometimes very distinctly mark out their boundaries, or the disorder may run its course without any recognised convulsive seizures.

Competing views

2021 ◽  
pp. 170-188
Author(s):  
Sven Rosenkranz
Keyword(s):  
Epistemic Possibility ◽  
Metaphysical Possibility ◽  
Propositional Justification ◽  
Present Account ◽  
Doxastic Justification ◽  
The Third ◽  
Justified Belief ◽  
Rule Out

The present account, which construes justification as a kind of epistemic possibility of knowing, or of being in a position to know, competes with three recently advanced theories of justification. Of these competitors, the first two construe doxastic justification as the metaphysical possibility of knowing. While they differ in some details, these views share certain problematic features: they fail to yield a corresponding account of propositional justification, have trouble vindicating an intuitive principle of closure for justified belief, and fail to comply with the independently plausible principle that if one has a justified belief, one is in no position to rule out that one has knowledge. The present account does not have these problematic features. According to the third competitor, |φ‎| is propositionally justified in one’s situation just in case it would be abnormal—and so require explanation—if |φ‎| were to be false in the presence of the evidence that one possesses in that situation. This normic theory of justification validates the principle that propositional justification agglomerates over conjunction, and in so doing, violates the constraint that propositions of the form ⌜φ‎ & ¬Kφ‎⌝ never be justified. It likewise contradicts the independently plausible principle that whenever |φ‎| is propositionally justified all things considered, |¬Kφ‎| is not. The present account does not face these problems, since it rejects the relevant agglomeration principle and treats the condition encoded by ⌜¬K¬Kφ‎⌝ as luminous.

scholarly journals Maternal and perinatal outcome in hypothyroidism in pregnancy: a prospective observational study

2017 ◽  
Vol 6 (12) ◽  
pp. 5548 ◽  
Author(s):  
Deepika Sharma ◽  
Pratibha V. Dixit ◽  
Yogita Gavit
Keyword(s):  
Observational Study ◽  
Early Pregnancy ◽  
Perinatal Outcome ◽  
Tertiary Care ◽  
Routine Screening ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
Newly Diagnosed ◽  
Thyroid Dysfunctions ◽  
In Pregnancy

Background: This study was conducted to analyse the antenatal complications, perinatal outcome and to be advocate routine screening for thyroid disorders in pregnancy. This study was prospective and observational study with 50 cases which was newly diagnosed when suspected as pregnancy with thyroid disorders. The commonest thyroid disorder found in pregnancy is hypothyroidism and it adversely affects the maternal and fetal health in the form of infertility, early pregnancy loss, PIH, anaemia, IUGR, PROM, preterm labor, neonatal and maternal morbidity and mortality. If thyroid disorders are appropriately detected and treated either before or in early pregnancy, the adverse maternal and fetal outcome can be prevented.Methods: The present study was conducted in a tertiary care centre Mumbai from June 2015 to October 2016. All pregnant females who are newly diagnosed as hypothyroid, attending the ANC clinic were enrolled in the study.Results: In the present study, most common obstetric complication observed was preeclampsia and most common fetal complication was preterm delivery.Conclusions: In view of the high prevalence of thyroid dysfunctions in Indian pregnant woman and its association with different adverse pregnancy related complications we recommend routine screening for thyroid dysfunctions in pregnancy.

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