scholarly journals An Update on the Epidemiological Features of Imported Schistosomiasis and Cystic Echinococcosis in Kuwait, 2010-2018

2021 ◽  
Author(s):  
Mohammad Al-Awadhi ◽  
Jamshaid Iqbal ◽  
Suhail Ahmad
Keyword(s):  
Cystic Echinococcosis ◽  
Neglected Tropical Diseases ◽  
Middle Eastern ◽  
National Laboratory ◽  
Epidemiological Data ◽  
Parasitic Infections ◽  
Successful Implementation ◽  
African Countries ◽  
True Incidence ◽  
Almost All

Objective: Kuwait is considered a non-endemic country for most parasitic infections. However, ~70% of 4.7 million residents in Kuwait are expatriates from Asian and African countries which are endemic for parasitic infections. Results of microbiological investigations for schistosomiasis and cystic echinococcosis performed in a reference national laboratory were retrospectively collected and analyzed to provide an insight on the epidemiology of these two neglected tropical diseases in Kuwait. Subjects and Methods: Schistosoma infection in fecal and urine specimens from suspected patients was detected by microscopy. Schistosoma and CE infections were also detected by indirect hemagglutination assays using blood specimens. Patients’ epidemiological data were extracted from the laboratory records. Results: The overall prevalence rates of schistosomiasis and CE were 19.0% and 5.8%, respectively. Almost all schistosomiasis cases were seen among Egyptians, especially among males, and a significantly higher prevalence (P <0.05) was seen for CE cases among the Syrian residents. A decreasing annual trend was observed for both the parasitic infections over time in Kuwait. Conclusion: Schistosomiasis is not autochthonous in Kuwait as all cases were detected among immigrants from Schistosoma-endemic countries. The decreasing trend is likely attributed to successful implementation of national and WHO strategies to control and prevent schistosomiasis in endemic countries. Our data showed that CE remains endemic among humans and livestock in Kuwait as is also seen in other Middle Eastern countries. Further investigations on the prevalence of CE in camels, livestock animals and dogs harboring the adult worm are needed to help estimate the true incidence of CE in humans in Kuwait.

scholarly journals Planning Considerations of Managed Aquifer Recharge (MAR) Projects in Jordan

Water ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 182 ◽  
Author(s):  
Elias Salameh ◽  
Ghaida Abdallat ◽  
Michael van der Valk
Keyword(s):  
Middle Eastern ◽  
Managed Aquifer Recharge ◽  
Successful Implementation ◽  
Aquifer Recharge ◽  
North African ◽  
African Countries ◽  
Groundwater Levels ◽  
Increasing Demand ◽  
North African Countries ◽  
Impacts Of Climate Change

This work discussed the conditions for the successful implementation of managed aquifer recharge, with various case studies in Jordan. The motivation behind this study was that many managed aquifer projects have been implemented in Jordan without adequate studies and they have since failed. Examples from Jordan were provided to serve as an illustration of Middle Eastern and North African countries, with their semi-arid to arid climates and increasing demand for water. The methodology included the evaluation of the implemented managed aquifer projects in Jordan and whether they achieved success or failure in fulfilling the purposes of aquifer recharging, as well as to clarify the reasons for the failure or success. The results showed that a minimum level of study must be carried out before starting any artificial recharge projects, such as defining the aquifer parameters and the water quality evolution after recharge, in addition to understanding of the fate of the recharged water. Managed aquifer recharge can alleviate the impacts of climate change by making use of unused water, and in the case of Jordan, it can alleviate the implications of dropping groundwater levels.

scholarly journals Intestinal parasitic infection in adult patients attending tertiary care hospitals: a retrospective study

2017 ◽  
Vol 4 (5) ◽  
pp. 1458
Author(s):  
Shyamal Kanti Pal ◽  
Rituparna Bhattacharya ◽  
Promukh Bhattacharya ◽  
Uttam Kumar Paul
Keyword(s):  
Retrospective Study ◽  
Neglected Tropical Diseases ◽  
Intestinal Parasites ◽  
Tertiary Care ◽  
Parasitic Infection ◽  
Epidemiological Data ◽  
Parasitic Infections ◽  
Concentration Technique ◽  
Positive Stool ◽  
Age Range

Background: Intestinal parasitic infections (IPI) are recognized as neglected tropical diseases. Inadequacy of epidemiological data reporting the prevalence of intestinal parasites among the general population prompted this retrospective study conducted among the Departments of Medicine and Microbiology of two medical colleges.Methods: All the symptomatic patients were examined for IPI.  831 parasite positive stool samples were included for the study. The age range of the patients were above 18 years. Stool specimens were processed using formol-ether concentration technique. Routine microscopic examination (saline and Lugol’s iodine mounts) were carried out for ova, cysts or parasites. The sample was partly preserved in 10% formal saline and later concentrated and fixed with methanol before staining by modified Ziehl Neelsen stain. Results: Out of the 831 positive samples, E. histolytica was predominant with 337 (40.55%) of all cases. The next in order were Giarrdia lamblia 216 (25.99%), A. lumbricoides with 173 (20.81%), E. vermicularis with 43 (5.17%), A. duodenale with 23 (2.76%), H. nana with 19 (2.28%), S. stercoralis with 17 (2.04%) and Taenia with 3 (0.36%). 134 patients had double parasites isolated, while only 3 had triple parasitic infestation.Conclusion: Present study showed a preponderance in gender towards males (59.4%) than females (40.5%). Larger sample size and more surveillance studies will help to establish effective measures and evidence-based approaches to curb the parasitic proliferation in this region. 

Ghana: the State of Agriculture and Prospects for Food Security in the Context of Achieving SDGs

2018 ◽  
pp. 16-31
Author(s):  
Tatyana Denisova
Keyword(s):  
Food Security ◽  
Socioeconomic Development ◽  
Agricultural Sector ◽  
Well Being ◽  
The State ◽  
Successful Implementation ◽  
Careful Study ◽  
African Countries ◽  
Development Goals ◽  
The Government

For the first time in Russian African studies, the author examines the current state of agriculture, challenges and prospects for food security in Ghana, which belongs to the group of African countries that have made the most progress in achieving the Sustainable Development Goals (SDGs). The SDGs are a collection of 17 global goals adopted by UN member states in 2015 with a view of achieving them by 2030. The SDGs include: ending poverty in all its forms everywhere (Goal 1); ending hunger, achieving food security and improved nutrition, and promoting sustainable agriculture (2); ensuring healthy lives and promoting well-being for all at all ages (3), etc. These goals are considered fundamental because the achievement of a number of other SDGs – for example, ensuring quality education (4), achieving gender equality (5), ensuring sustainable consumption and production patterns (12), etc. – largely depends on their implementation. Ghana was commended by the world community for the significant reduction in poverty, hunger and malnutrition between 2000 and 2014, i.e. for the relatively successful implementation of the first of the Millennium Development Goals (MDGs, 2000–2015) – the eradication of extreme poverty and hunger. However, SDGs require more careful study and planning of implementation measures. In order to achieve the SDGs, the Government of Ghana has adopted a number of programs, plans and projects, the successful implementation of which often stumbles upon the lack of funding and lack of coordination between state bodies, private and public organizations, foreign partners – donors and creditors, etc., which are involved in the processes of socioeconomic development of Ghana. The author determines the reasons for the lack of food security in Ghana, gives an assessment of the state of the agricultural sector, the effective development of which is a prerequisite for the reduction of poverty and hunger, primarily due to the engagement of a significant share (45%) of the economically active population in this sector. The study shows that the limited growth in food production is largely due to the absence of domestic markets and necessary roads, means of transportation, irrigation and storage infrastructure, as well as insufficient investment in the agricultural sector, rather than to a shortage of fertile land or labor.

Naphthoquinones and derivatives for chemotherapy: perspectives and limitations of their anti-trypanosomatids activities

2020 ◽  
Vol 26 ◽  
Author(s):  
Luíza Dantas-Pereira ◽  
Edézio F. Cunha-Junior ◽  
Valter V. Andrade-Neto ◽  
John F. Bower ◽  
Guilherme A. M. Jardim ◽  
...  
Keyword(s):  
Large Scale ◽  
Neglected Tropical Diseases ◽  
Folk Medicine ◽  
Leishmania Species ◽  
Parasitic Infections ◽  
Mechanistic Analysis ◽  
Leishmania Spp ◽  
Nanomolar Range

: Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered neglected tropical diseases, and they especially affect impoverished populations in the developing world. The available chemotherapies are very limited and a search for alternatives is still necessary. In folk medicine, natural naphthoquinones have been employed for the treatment of a great variety of illnesses, including parasitic infections. This review is focused on the anti-trypanosomatid activity and mechanistic analysis of naphthoquinones and derivatives. Among all the series of derivatives tested in vitro, naphthoquinone-derived 1,2,3-triazoles were very active on T. cruzi infective forms in blood bank conditions, as well as in amastigotes of Leishmania spp. naphthoquinones containing a CF3 on a phenyl amine ring inhibited T. brucei proliferation in the nanomolar range, and naphthopterocarpanquinones stood out for their activity on a range of Leishmania species. Some of these compounds showed a promising selectivity index (SI) (30 to 1900), supporting further analysis in animal models. Indeed, high toxicity to the host and inactivation by blood components are crucial obstacles to be overcome to use naphthoquinones and/or their derivatives for chemotherapy. Multidisciplinary initiatives embracing medicinal chemistry, bioinformatics, biochemistry, and molecular and cellular biology need to be encouraged to allow the optimization of these compounds. Large scale automated tests are pivotal for the efficiency of the screening step, and subsequent evaluation of both the mechanism of action in vitro and pharmacokinetics in vivo are essential for the development of a novel, specific and safe derivative, minimizing adverse effects.

Using novel methodologies to support burden of disease estimates

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
T Hald
Keyword(s):  
International Development ◽  
Traditional Approach ◽  
Source Population ◽  
Surveillance Systems ◽  
Data Generation ◽  
Time Data ◽  
African Countries ◽  
Indirect Measure ◽  
True Incidence ◽  
Laboratory Capacity

Abstract A challenge to estimating burden of diarrheal diseases, particularly in LMICs, where laboratory capacity and surveillance systems are limited, is obtaining valid estimates of etiology proportions of cases. A commonly used method is systematic review of studies reporting pathogen isolation in diarrhea cases. However, studies often differ in design, source population, timeframe, and pathogens included, hampering extrapolation to the target population. In a study co-funded by the Bill and Melinda Gates Foundation and the UK Department for International Development, we explore a novel approach for estimating diarrhea etiology proportions in urban and rural populations in four African countries. We analyse sewage samples using short-read next-generation sequencing (NGS) to determine abundance of genes that can be mapped to specific bacterial genera, providing an estimate of the relative abundance of specific pathogens in each sample. In parallel to collecting sewage samples, a questionnaire-based population survey will estimate diarrheal incidence. By combining results, pathogen-specific incidence will be estimated and compared with incidence estimates from the traditional approach. The application NGS to human sewage has great potential for surveillance of foodborne infections, particularly in resource-poor settings where laboratory capacity for bacterial isolation is limited. First, NGS is a one method takes all approach, as it is based on detection of RNA/DNA, a language common across pathogens. Second, it is culture independent, allowing for real-time data generation and standardized sharing. Finally, few samples are needed to survey large populations for several pathogens at the same time. Thus, surveillance based on NGS of sewage may prove to be an indirect measure of incidence. Although it will not provide an estimate for the true incidence in the population, it will increase our understanding of the burden and as such be a proxy and novel way of ranking diseases.

scholarly journals Human and animal cystic echinococcosis in Tataouine governorate: hypoendemic area in a hyperendemic country, myth or reality?

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Selim M’rad ◽  
Raja Chaâbane-Banaoues ◽  
Massaouda Ghrab ◽  
Hamouda Babba ◽  
Myriam Oudni-M’rad
Keyword(s):  
Environmental Contamination ◽  
Cystic Echinococcosis ◽  
Mediterranean Area ◽  
Control Programme ◽  
Effective Control ◽  
Contamination Rate ◽  
Hydatid Cysts ◽  
African Countries ◽  
Serological Tests ◽  
Sera Samples

Abstract Background Cystic echinococcosis (CE) has a worldwide distribution and is especially prevalent in North African countries. With a mean annual surgical incidence (ASI) of CE of 12.7 per 100,000 inhabitants, Tunisia is one of the most CE endemic countries in the Mediterranean area. Tataouine governorate is considered to be the most CE hypoendemic region in Tunisia (ASI = 0.92) despite favourable socioeconomic conditions that enable maintenance of the Echinococcus granulosussensu lato (s.l.) life-cycle and a significant environmental contamination with E. granulosuss.l. eggs. The aim of this study was to assess human CE seroprevalence, prevalence of CE in food animals and environmental contamination by E. granulosus s.l. eggs in different districts of Tataouine governorate. Methods This study was conducted from January to December 2018. A total of 374 human sera samples were tested for the presence of immunoglobulin G antibodies against E. granulosus using a commercial ELISA kit. Specimens were also collected from animals slaughtered at the Tataouine abattoir (n = 8609) and examined for the presence of hydatid cysts; 111 hydatid cysts were genotyped. Eggs of E. granulosuss.l. were identified by PCR and DNA sequencing from dog faecal samples (n = 288). Results Serological tests showed that 8.5% of the sera samples tested were positive for E. granulosus-specific antibodies. The average prevalence of hydatidosis in livestock was 1.6%, and CE infection was more prevalent in cattle than in sheep, goats and dromedaries. The contamination rate of dog faeces by E. granulosus sensu stricto eggs varied significantly from 0 to 23.5% depending on the collection area. Molecular analyses only revealed the presence of the G1 genotype for cysts and eggs. Conclusions Based on our findings, CE is likely to be more endemic in the Tataouine governorate than previously described. Thus, to implement an effective control programme against CE, a national survey should be carried out to determine human CE prevalence in the different Tunisian governorates. Graphic Abstract

scholarly journals Prevalence and factors associated with intestinal schistosomiasis and human fascioliasis among school children in Amhara Regional State, Ethiopia

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Teshome Bekana ◽  
Nega Berhe ◽  
Tadesse Eguale ◽  
Mulugeta Aemero ◽  
Girmay Medhin ◽  
...  
Keyword(s):  
Risk Factors ◽  
School Children ◽  
Neglected Tropical Diseases ◽  
Significant Risk ◽  
Parasitic Infections ◽  
Cross Sectional ◽  
Targeted Interventions ◽  
Intestinal Schistosomiasis ◽  
Regional State ◽  
Human Fascioliasis

Abstract Background Schistosomiasis and fascioliasis are digenean parasitic infections and are among the neglected tropical diseases that have both medical and veterinary importance. They are found mainly in areas having limited access to safe water supply and improved sanitation. Methods A cross-sectional study was conducted to determine the prevalence of Schistosoma mansoni and Fasciola species infections and to identify associated risk factors among school children in Amhara Regional State, Ethiopia. Stool specimens were collected from 798 children (419 males, 379 females) and processed using Kato-Katz and formol-ether concentration techniques. A semi-structured questionnaire was used to collect socio-demographic and other exposure information to explore potential risk factors for the infections. Results The overall prevalence of S. mansoni and Fasciola species infections was 25.6% (95% confidence interval (CI): 22.5-28.6) and 5.5% (95% CI: 3.9-7.1), respectively. S. mansoni was present in all surveyed schools with the prevalence ranging from 12.8% (16/125; 95% CI = 5.6-20.0) to 39.7% (64/161; 95% CI = 32.2-47.2) while Fasciola species was identified in five schools with the prevalence ranging from 2.5% (4/160; 95% CI = 0.001–4.9) to 9.8% (13/133; 95% CI = 4.7–14.8). The prevalence of S. mansoni infection was significantly associated with swimming in rivers (Adjusted odds ratio (AOR): 1.79, 95% CI, 1.22–2.62; P=0.003), bathing in open freshwater bodies (AOR, 2.02; 95% CI, 1.39–2.94; P<0.001) and engaging in irrigation activities (AOR, 1.69; 95% CI, 1.19-2.39; P=0.004), and was higher in children attending Addis Mender (AOR, 2.56; 95% CI, 1.20–5.46; P=0.015 ) and Harbu schools (AOR, 3.53; 95% CI, 1.64–7.59; P=0.001). Fasciola species infection was significantly associated with consumption of raw vegetables (AOR, 2.47; 95% CI, 1.23-4.97; P=0.011) and drinking water from unimproved sources (AOR, 2.28; 95% CI, 1.11–4.70; P=0.026). Conclusion Both intestinal schistosomiasis and human fascioliasis are prevalent in the study area, affecting school children. Behaviors and access to unimproved water and sanitation are among significant risk factors. The findings are instrumental for targeted interventions.

scholarly journals Human Cystic Echinococcosis in Lebanon: A Retrospective Study and Molecular Epidemiology

2021 ◽  
Author(s):  
Gaelle Joanny ◽  
Maria Grazia Cappai ◽  
Francesca Nonnis ◽  
Claudia Tamponi ◽  
Giorgia Dessì ◽  
...  
Keyword(s):  
Echinococcus Granulosus ◽  
Cystic Echinococcosis ◽  
Epidemiological Data ◽  
Sensu Stricto ◽  
Control Measures ◽  
Mediterranean Countries ◽  
High Gene ◽  
Human Infections ◽  
And Control ◽  
Human Cystic Echinococcosis

Abstract Purpose Human cystic echinococcosis (CE) is a zoonotic parasitic disease that constitutes a public health challenge and a socio-economic burden in endemic areas worldwide. No specific surveillance system of CE infections in humans exists in Lebanon. The incidence and trends over time have not been documented. The current study aimed to assess the demographic and epidemiologic features of human CE surgical cases over a 14-year period in the five main regions of Lebanon. Methods From 2005 to 2018, a total of 894 surgically confirmed cases of hydatidosis were recorded from five anatomy and pathology laboratories. Results The mean annual surgical incidence was 1.23/100,000 inhabitants. Over the span of these years, the incidence increased from 0.53 to 1.94 cases/100,000 inhabitants in 2005 and 2018, respectively. CE is present in Lebanon with an uneven distribution from one region to the other with higher prevalence in Bekaa (29.0%), a rural area where sheep raising is widespread. Human CE cases were more common in females (60.1%) than in males (39.9%) and a high burden of infection was reported for the age group of 30–39 years. Besides, 66.7% of the cases expressed only liver complications whereas, 20.5% showed predilection towards lungs. The 7.8% of cases presented cysts in other organs, and 1.3% showed multiple localizations. Additionally, predominant involvement of Echinococcus granulosus sensu stricto was recorded in human infections. Comparison of Echinococcus granulosus s.s. populations from different Mediterranean countries also revealed high gene flow among this region and sharing of alleles. Conclusion The current study is a step forward to fill the gap of knowledge for the hydatidosis in Lebanon where the lack of epidemiological data and control measures have resulted in higher incidence of human CE. Graphic Abstract

scholarly journals A Review of Climate-Smart Agriculture Research and Applications in Africa

Agronomy ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1255
Author(s):  
Paul M. Barasa ◽  
Christina M. Botai ◽  
Joel O. Botai ◽  
Tafadzwanashe Mabhaudhi
Keyword(s):  
Climate Change ◽  
Research Field ◽  
Successful Implementation ◽  
Collaboration Networks ◽  
African Countries ◽  
Government Programs ◽  
Agricultural Adaptation ◽  
Strategic Plans ◽  
Smart Agriculture ◽  
Support Decision Making

Funders and governments are promoting climate-smart agriculture (CSA) as key to agricultural adaptation under climate change in Africa. However, with its progressions still at the policy level and framework description, there is a need to understand the current developments and activities conducted within the CSA research field. We conducted a scientific mapping and analyses of CSA research studies in Africa to understand the (i) thematic trends, (ii) developments, (iii) nature of collaboration networks, and (iv) general narratives supporting the adoption and application of CSA in Africa. Results show that several African countries had endorsed CSA as an approach to addressing agricultural productivity challenges, supporting adaptation strategies, and building resilience to climate change. However, a majority do not have national Climate-Smart Agriculture Investment Plans (CSAIPs). Additionally, CSA research in Africa is still developing, with only a few countries dominating the research outputs. For a successful implementation of CSA, a framework provided by the CSAIPs must be established to guide the processes. This will provide a framework to guide the integration of government programs, policies, and strategic plans by combining other inputs from stakeholders to support decision making and implementation of CSA.

Earnings management and ownership structure in emerging market

2017 ◽  
Vol 43 (10) ◽  
pp. 1117-1136 ◽  
Author(s):  
Naima Lassoued ◽  
Mouna Ben Rejeb Attia ◽  
Houda Sassi
Keyword(s):  
Emerging Markets ◽  
Earnings Management ◽  
Ownership Structure ◽  
Audit Quality ◽  
Emerging Market ◽  
Middle Eastern ◽  
Convincing Evidence ◽  
Loan Loss ◽  
African Countries ◽  
Content Type

Purpose The purpose of this paper is to investigate whether ownership structure affects earnings management in the banking industry of emerging markets. Design/methodology/approach The empirical study is conducted using a sample of 134 banks from 12 Middle Eastern and North African countries. Econometrically speaking, the study used a panel data regression analysis. Findings The authors found convincing evidence that banks with more concentrated ownership use discretionary loan loss provisions to manage their earnings. The authors also found that state and institutional owners encourage earnings management, while family owners reduce this practice. Practical implications The findings would be valuable for investors since they should take into account ownership structure in order to reach a better investment decision. Moreover, regulatory reforms in emerging markets should push for more transparency about ownership structure, high levels of supervision, and external audit quality. Originality/value This study presents international evidence on the prominent role of owners in earnings management in emerging markets with weak shareholder rights protection.

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