scholarly journals Conjunctival Chemosis and Annular Ciliochoroidal Detachments Detected by Anterior-Segment Optical Coherence Tomography in a Case of Systemic Lupus Erythematosus

2021 ◽  
pp. 154-158
Author(s):  
Akiko Ishida ◽  
Yukari Yamane ◽  
Yasurou Koyama ◽  
Manabu Honda ◽  
Masahiro Kondo ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Optical Coherence Tomography ◽  
Lupus Erythematosus ◽  
Anterior Segment ◽  
Pulse Therapy ◽  
Japanese Woman ◽  
Optical Coherence ◽  
Systemic Lupus ◽  
Swept Source ◽  
Steroid Pulse

A 61-year-old Japanese woman presented to our hospital for treatment of systemic serositis associated with systemic lupus erythematosus (SLE). At the initial ophthalmologic examination, her best-corrected visual acuity was 1.2 and 0.6 in her right and left eyes, respectively. Slit-lamp examination showed marked chemosis in both eyes (OU). Swept source-based, anterior-segment optical coherence tomography (AS-OCT) clearly showed conjunctival elevations corresponding to the chemosis in all scan directions OU. In some scans, hyporeflective spaces with luminal structures corresponding to dilated lymphatic channels and nonluminal structures corresponding to interstitial fluid accumulation were seen clearly under the conjunctival epithelium and/or in the parenchyma. In all scan directions, the supraciliary space was seen clearly, suggesting the presence of an annular ciliochoroidal detachment. Fundus examinations showed retinal edema temporal to the optic nerve head and subfoveal serous retinal detachments OU. Ocular effusions resolved by 2 weeks after the start of steroid pulse therapy, and pleural effusions and ascites resolved and pericardial effusion decreased by 2 months. AS-OCT can be useful for understanding the mechanism(s) of the less common anterior-segment ocular manifestations of SLE.

scholarly journals Optical Coherence Tomography Angiography as a New Tool for Evaluation of the Subclinical Retinal Involvement in Patients with Systemic Lupus Erythematosus—A Review

2021 ◽  
Vol 10 (13) ◽  
pp. 2887
Author(s):  
Małgorzata Mimier-Janczak ◽  
Dorota Kaczmarek ◽  
Dawid Janczak ◽  
Radosław Kaczmarek
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Optical Coherence Tomography ◽  
Lupus Erythematosus ◽  
Optical Coherence Tomography Angiography ◽  
Diagnostic Process ◽  
Optical Coherence ◽  
Systemic Lupus ◽  
Asymptomatic Patients ◽  
Pubmed Database ◽  
Lupus Retinopathy

Knowing the proven relationship between lupus retinopathy and systemic changes and disease activity, it is crucial to find the possibility of early diagnosis of retinal changes at a subclinical level in order to provide faster medical intervention and protect the patient from irreversible changes in the eye and other organs. The aim of this review is an analysis of studies investigating early pathological changes in retinal vascularization obtained by optical coherence tomography angiography (OCTA) and their relationship to the systemic lupus erythematosus (SLE). A literature search was performed to identify all relevant articles, regarding detection of subclinical retinal changes using OCTA in systemic lupus erythematosus listed in PubMed database. Seven out of seven papers found showed a decrease in superficial capillary plexus in ocular asymptomatic patients diagnosed with SLE. A decrease in retinal vessel density measured by OCTA may be a good marker of SLE activity and poor prognosis. OCTA in a safe manner can give clinicians a new perspective on processes of vessel remodeling and answer the question of how SLE might impact the eye from a structural point of view. Adding OCTA to the standard diagnostic process of SLE patients, may detect systemic changes early and prevent further visual deterioration by stopping progression of lupus retinopathy.

Subclinical Foveal Vasculopathy in Patients With Systemic Lupus Erythematosus Using Optical Coherence Tomography Angiography

2019 ◽  
Vol 3 (5) ◽  
pp. 283-288 ◽  
Author(s):  
Chirag Shah ◽  
Rami Gabriel ◽  
Sanjay Kedhar ◽  
Baruch Kuppermann ◽  
Mitul Mehta
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Optical Coherence Tomography ◽  
Lupus Erythematosus ◽  
Optical Coherence Tomography Angiography ◽  
Small Sample ◽  
Clinical Staging ◽  
Optical Coherence ◽  
Systemic Lupus ◽  
The Mean ◽  
Retinal Capillaries

Purpose: This article identifies subclinical microvascular changes in systemic lupus erythematosus (SLE) patients using vascular perfusion densities derived from optical coherence tomography angiography (OCTA). Methods: A retrospective review was performed on individuals with SLE (10 eyes of 5 patients) and age-matched controls imaged with a spectral-domain OCT system (XR Avanti, Optovue, Inc). A split-spectrum amplitude-decorrelation algorithm (SSADA) generated OCTA of the superficial retinal capillaries, deep retinal capillaries, and foveal avascular zone (FAZ). Skeletonized OCTAs were used to create capillary vessel density (VD) values for each image. VD values were compared with clinical staging, and groups were compared using Kruskal–Wallis and Mann–Whitney tests. Results: Both the superficial (SCP) and deep capillary plexus (DCP) had a statistically significant decrease in VD in the SLE group when compared with the control group ( P < .05). The average VD ± SD for normal individuals in the 3 mm × 3 mm scans was 26.11 ± 1.2 and 37.45 ± 1.8 for the SCP and DCP, respectively. For SLE patients the mean ± SD was 18.46 ± 0.84 and 30.22 ± 1.5 for SCP and DCP, respectively. The mean FAZ was found to be 0.207 mm ± 0.02 for healthy controls and 0.350 mm ± 0.02 for SLE patients ( P < .001). Conclusions: In this paper we demonstrate a significantly enlarged FAZ and decreased VD in a small sample of patients with lupus. The SCP VD demonstrated a dose-response–type negative relationship with increased systemic lupus severity. Larger-sample, prospective studies may allow us to further characterize subclinical SLE pathology with OCTA, and OCTA may further provide a means for monitoring the severity or progression of other microvascular diseases.

Central nervous system manifestations after steroid pulse therapy in systemic lupus erythematosus

2002 ◽  
Vol 161 (9) ◽  
pp. 503-504 ◽  
Author(s):  
Yuichi Tabata ◽  
Ichiro Kobayashi ◽  
Nobuaki Kawamura ◽  
Motohiko Okano ◽  
Kunihiko Kobayashi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Central Nervous System ◽  
Nervous System ◽  
Lupus Erythematosus ◽  
Pulse Therapy ◽  
Steroid Pulse Therapy ◽  
Systemic Lupus ◽  
Steroid Pulse
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