scholarly journals Castleman’s Disease Arising from the Hepatoduodenal Ligament Mimicking a Duodenal Gastrointestinal Stromal Tumor

2021 ◽  
pp. 424-430
Author(s):  
Koichi Oishi ◽  
Kazuhiro Toyota ◽  
Manabu Shimomura ◽  
Tadateru Takahashi
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
High Intensity ◽  
Frozen Section ◽  
Abdominal Mass ◽  
Castleman’S Disease ◽  
Stromal Tumor ◽  
Hepatoduodenal Ligament ◽  
Castleman's Disease ◽  
Vascular Proliferation ◽  
High Intensity Signal

Castleman’s disease (CD) arising from the hepatoduodenal ligament is extremely rare. A 32-year-old man was referred to a clinic with nausea. He was found to have an abdominal mass by ultrasonography and consulted our hospital for further examination. Computed tomography revealed an equally enhancing mass, 5.2 cm in diameter, adjacent to the duodenum. On magnetic resonance imaging, the mass revealed a slightly iso-intensity signal equal to smooth muscle on T1-weighted imaging, a slightly high-intensity signal on T2-weighted imaging, and a high-intensity signal on diffusion-weighted imaging. Endoscopic ultrasonography showed a well-demarcated hypoechoic mass adjacent to the duodenum. The Doppler echo pattern indicated abundant blood flow. The preoperative diagnosis was a duodenal gastrointestinal stromal tumor. The patient underwent laparotomy and tumor excision. The finding of the intraoperative frozen section was CD. Histologically, the lymph follicles were markedly increased in number throughout the cortex and medulla with vascular proliferation and hyalinization in the intra- or extra-follicles. The germinal centers were atrophic and surrounded by concentrically arranged layers of small lymphocytes. The histological findings were the hyaline vascular variant of CD. If a hypervascular solid mass is detected in the abdomen, CD should be considered in the differential diagnosis.

scholarly journals Gastrointestinal Stromal Tumor of the Stomach with Castleman’s Disease

2015 ◽  
Vol 48 (12) ◽  
pp. 977-983
Author(s):  
Soichiro Murakami ◽  
Toshinaga Nabae ◽  
Akiko Sagara ◽  
Masahiko Kawamoto ◽  
Shyuyo Umeda ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Castleman’S Disease ◽  
Stromal Tumor ◽  
Castleman's Disease

scholarly journals Unicentric Castleman’s Disease in a Man Originally Diagnosed with Sarcoidosis: A Case and Analysis of the Key Differences in Diagnosis

2019 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Lymph Nodes ◽  
Surgical Resection ◽  
Lymphoproliferative Disorder ◽  
Castleman’S Disease ◽  
Castleman Disease ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Complete Surgical Resection ◽  
Vascular Proliferation

Castleman Disease (CD) is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. There are two types: unicentric and multicentric. Unicentric, hyalinevascular type of Castleman’s disease can be treated successfully with complete surgical resection with monitoring for reoccurrence. Here we report a case of a patient originally diagnosed with sarcoidosis who was found to have Unicentric Castleman’s disease.

scholarly journals Role of Fine needle aspiration cytology in the diagnosis of Cervical lymphadenopathy

1970 ◽  
Vol 14 (2) ◽  
pp. 63-65 ◽  
Author(s):  
Md Arif Hossain Bhuiyan ◽  
Md Abu Yusuf Fakir ◽  
ABM Tofazzal Hossain ◽  
AHM Zahurul Huq ◽  
Sanjeev Gupta
Keyword(s):  
Frozen Section ◽  
Castleman’S Disease ◽  
Cervical Lymphadenopathy ◽  
Neck Surgery ◽  
Needle Aspiration ◽  
Lymphoid Hyperplasia ◽  
Lymph Node Biopsy ◽  
Castleman's Disease ◽  
Needle Aspiration Cytology ◽  
Set Up

Objective: A study was carried out to know the overall prevalence of various causes responsible for cervical lymphadenopathy of more than 3 weeks duration. FNAC has been evaluated as a diagnostic tool in our clinical set up. We aimed to present 110 cases which we treated in our center within last 3½ years. Methods: A retrospective study has been carried out from June 2005 to December 2008 in the department of Otolaryngology and Head-Neck Surgery at Apollo Hospitals Dhaka. All patients presented with cervical lymphadenopathy of more than 3 weeks duration. FNAC has been done for all suspected cases. CT neck has been done in 4 cases for deep jugular nodes. 55 patients underwent biopsy as FNAC report was non-specific lymphadenitis. For three cases we have done frozen section biopsy. Preoperative workup with routine blood tests, Xray chest and tuberculin tests have been carried out for all cases. Results: Out of 110 FNAC of cervical lymphadenopathy - 55 were non-specific lymphadenitis, 32 were tuberculosis, 12 were metastatic (with 2 occult primary), 6 were lymphomas(Immunocytochemistry proved ) and 5 were abscess. All 55 non-specific lymphadenopathy cases (FNAC report) underwent lymph node biopsy.5 cases were consistent with tuberculosis , 1 was lymphoma and rest were reactive . For 3 cases frozen section biopsy have been done. One was consistent with granulomatous disease and two cases were diagnosed as lymphoid hyperplasia. Both the lymphoid hyperplasia cases have been diagnosed as Castleman's disease after histopathology report. Conclusion: The study concluded the fact that the non-specific infection is the most common cause of cervical lymphadenopathy followed by tuberculosis .Supplemented with routine laboratory investigations, FNAC give very important clue to the physicians among patients presented with cervical lymphadenopathy. Key Words: Lymphadenopathy, lymphoid hyperplasia, tuberculosis, lymphoma, castleman's disease.  DOI: 10.3329/bjo.v14i2.3283 Bangladesh J of Otorhinolaryngology 2008; 14(2) : 63-65

scholarly journals Unusual Appearance of a Pendulated Gastric Tumor: Always Think of GIST

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Kristel De Vogelaere ◽  
Vanessa Meert ◽  
Frederik Vandenbroucke ◽  
Georges Delvaux ◽  
Anne Hoorens
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Mutational Analysis ◽  
Abdominal Mass ◽  
Molecular Genetic ◽  
Large Mass ◽  
Clinicopathological Characteristics ◽  
Stromal Tumor ◽  
Cystic Degeneration ◽  
Genetic Characteristics ◽  
Cystic Changes

Objective. To investigate the clinicopathological characteristics of gastrointestinal stromal tumor (GIST) with significant cystic changes and to assess the molecular genetic characteristics.Methods. In a 68-year-old man, a large abdominal tumoral mass was discovered incidentally. Computed tomography (CT) and magnetic resonance imaging (MRI) confirmed the presence of a large cystic lesion with multiple contrast-enhancing septae and papillary projections. No clear connection with any of the surrounding organs was identified. Malignancy could not be excluded, and surgery was indicated. During surgery, the large mass was found to be attached by a narrow stalk to the large curvature of the stomach.Results. The histological features and immunohistiochemical profile of the tumor cells (positivity for CD117 and CD34) were consistent with a gastrointestinal stromal tumor with a high risk of progressive disease according to the Fletcher classification. Diagnosis was confirmed by mutational analysis; this demonstrated mutation in exon 14 of PDGFRA. During the followup of 97 months, the patient had a cancer-free survival.Conclusions. This case demonstrates that gastrointestinal stromal tumors (GISTs) with extensive cystic degeneration should be considered in the differential diagnosis of a cystic abdominal mass.

scholarly journals An Atypical Equine Gastrointestinal Stromal Tumor

2009 ◽  
Vol 21 (3) ◽  
pp. 387-390 ◽  
Author(s):  
Kathleen B. Muravnick ◽  
Eric J. Parente ◽  
Piero Del Fabio
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Transverse Colon ◽  
Abdominal Mass ◽  
Clinical Signs ◽  
Neuron Specific Enolase ◽  
Giant Cells ◽  
Stromal Tumor ◽  
Nerve Sheath Tumor ◽  
Multinucleated Giant Cells ◽  
Immunohistochemical Profile

A 17-year-old, gelded Quarter Horse cross was found to have a large, intra-abdominal mass. Clinical signs included infrequent mild colic, weight loss, and chronic anemia. Surgery revealed a very large, discrete, hemorrhagic, multilobular mass with vascular attachments to the transverse colon, mesocolon, jejunal mesentery, and omentum; the site of origin was the transverse colon. Histologic examination demonstrated dense sheets, fascicles, palisades, and interconnecting streams of neoplastic spindle cells with lesser numbers of admixed multinucleated giant cells. Based on morphology alone, this neoplasm might have been misdiagnosed as a peripheral nerve sheath tumor because many of the morphologic features were suggestive of neural differentiation. Neoplastic cells expressed cluster of differentiation (CD)117 (c-kit), vimentin, desmin, smooth muscle actin, neuron-specific enolase, and S-100 protein and did not express cytokeratin. Based predominantly on the immunohistochemical profile, especially the CD117 positivity, this neoplasm was diagnosed as a gastrointestinal stromal tumor with both myogenic and neurogenic differentiation. The morphology and immunohistochemical profile of this neoplasm were different from published cases of equine gastrointestinal stromal tumors. Unusual aspects included the large size of this neoplasm, the neuroid rather than myxomatous morphology, the presence of multinucleated giant cells, and the expression of desmin.

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